Ultraviolet light transmission through the human corneal stroma is reduced in the periphery
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This article investigates in vitro light transmission through the human cornea in the ultraviolet (UV) portion of the electromagnetic spectrum as a function of position across the cornea from center to periphery. Spectrophotometry was used to measure UV transmission in the wavelength range 310-400 nm, from the central cornea to its periphery. UV transmission decreases away from the center, and this is attributed to scattering and absorbance. Corneal endothelial cells, which line the back of the cornea and are more numerous in the periphery, therefore receive a lower dose of UV than do those in the central cornea. This is consistent with the recent observation that endothelial cells in the corneal periphery exhibit less nuclear oxidative DNA damage than those in the central cornea.
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UV transmission through the cornea decreases from the centre to the periphery, attributed to a combination of scattering and absorption.
“We found that UV transmission through the cornea decreases from the centre to the periphery, and attributed this to a combination of scattering and absorption (Doutch et al., 2012).”
From Corneal structure and transparency (2015) · cites this paper as Doutch et al., 2012
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Research works printed but not linked: 3
- [2]2. Hogan, M. J., J. A. Alvarado, and J. E. Weddell. 1971. Histology of the Human Eye: An Atlas and Textbook. WB Saunders, Philadelphia, PA.
- [8]8. Farrell, R. A., and R. L. McCally. 2000. Corneal transparency. In Principles and Practice of Ophthalmology. D. M. Albert and F. A. Jakobiec, editors. WB Saunders, Philadelphia, PA. 629-643.
- [11]11. Feuk, T. 1970. On the transparency of the stroma in the mammalian cornea. IEEE Trans. Biomed. Eng. 17:186-190.
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
Self-citationLucas, R. M., Norval, M., Neale, R. E., Young, A. R., de Gruijl, F. R., Takizawa, Y., & van der Leun, J. C. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c4pp90033b · Cited by 158 · see citing works
- Authors
- Doutch, J. J., Quantock, A. J., Joyce, N. C., & Meek, K. M.
- Affiliations
- Cardiff University (GB)
- Harvard University (US)
- Corresponding author
- Meek, Keith M.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 102
- Issue
- 6
- Pages
- 1258-1264
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC3309274
- OpenAlex
- W2117715364
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 1 · 2015: 3 · 2014: 8 · 2013: 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- The Australian Nuclear Science and Technology Organisation Institutional Repository (The Australian Nuclear Science and Technology Organisation) (submittedVersion)
- Funders
- Medical Research Council (G0600755)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular and Laser Science Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Keywords
- human cornea, corneal stroma, corneal periphery, light scattering, optical absorption, corneal endothelial cells, UV dose, oxidative DNA damage
- MeSH terms
- Absorption, Adult, Aged, Corneal Stroma, Humans, Middle Aged, Scattering, Radiation, Ultraviolet Rays, Imaging, Three-Dimensional, Light Signal Transduction
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