Regulation of Bace1 Mrna Expression in Alzheimer’S Disease by Green Tea Catechins and Black Tea Theaflavins
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Phenolic and flavonoid contents, catechins, coumarin, resveratrol, quercetin, curcumin, ginkgolide, glycyrrhizin, monoterpenoid, and S-allylcysteine isolated from various medicinal plants have been identified to have the potency to prevent Alzheimer's disease.
“Phenolic and flavonoid contents [91], catechins [92], coumarin [93], resveratrol [94], quercetin [95]; curcumin [96], ginkgolide [97], glycyrrhizin [98], monoterpenoid [99], and S-allylcysteine [100] which isolated from various medicinal plants have been identified to have the potency to prevent AD.”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [92]
Cited by
Sorted by citations
Ovais, M., Zia, N., Ahmad, I., Khalil, A. T., Raza, A., Ayaz, M., Sadiq, A., Ullah, F., & Shinwari, Z. K. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00284 · Cited by 137 · see citing works
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
“Phenolic and flavonoid contents [91], catechins [92], coumarin [93], resveratrol [94], quercetin [95]; curcumin [96], ginkgolide [97], glycyrrhizin [98], monoterpenoid [99], and S-allylcysteine [100] which isolated from various medicinal plants have been identified to have the potency to prevent AD.”
BackgroundAssociation of Tea Consumption with Risk of Alzheimer’s Disease and Anti-Beta-Amyloid Effects of Tea
Polito, C. A., Cai, Z., Shi, Y., Li, X.-M., Yang, R., Shi, M., Li, Q., Ma, S., Xiang, L., Wang, K., et al. (2018) · Nutrients · doi:10.3390/nu10050655 · Cited by 89 · see citing works
“Tea polyphenols EGCG, EC, and TF suppressed oxidative stress-induced BACE-1 mRNA upregulation in neuronal cells, resulting in the reduction of amyloidogenic cleavage of APP and Aβ production [3,64].”
BackgroundInfluentialAboulwafa, M. M., Youssef, F. S., Gad, H. A., Altyar, A. E., Al‐Azizi, M. M., & Ashour, M. L. (2019) · Antioxidants · doi:10.3390/antiox8100455 · Cited by 83 · see citing works
“EC reduces amyloid-β-induced β-secretase-1 expression and thus inhibits the most toxic amyloid-β aggregates [165].”
BackgroundTherapeutic Properties of Green Tea: A Review
Ratnani, S., & Malik, S. (2022) · Journal of Multidisciplinary Applied Natural Science · doi:10.47352/jmans.2774-3047.117 · Cited by 39 · see citing works
“It blocks the formation of plaque related to Alzheimer diseases [8][9].”
BackgroundAtoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works
“Curcumin, [133] resveratrol, [134] phenolics and flavonoids, [135] coumarin, [136] ginkgolide, [137] quercetin, [138] glycyrrhizin, [139] catechins, [140] monoterpenoid, [141] and S-allylcysteine, [142] which were extracted from some plants like turmeric, Japanese knotweed, spices, Ginkgo biloba…”
Current Naturopathy to Combat Alzheimer’s Disease
Chakrovorty, A., Bhattacharjee, B., Saxena, A., Samadder, A., & Nandi, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220927121022 · Cited by 13 · see citing works
“…pharmacophores that foster their radical scavenging property [166] study performed on SH-SY5Y neuroblastoma cells validates the efficacy of cate-chins and theaflavins in the reduction of BACE1 mRNA expression induced by Aβ, with epicatechin and epigallocat-echin showing the maximal potency [167].”
BackgroundPromising Natural Remedies for Alzheimer’s Disease Therapy
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2025) · Molecules · doi:10.3390/molecules30040922 · Cited by 13 · see citing works
“Thearubigin [149] 54 , in Figure 5 In vitro (albino Wistar rats) Suppresses apoptosis (inhibits cytochrome c release, expression of Bax, caspases-3, 8, and 9, promotes Bcl-2 expression), oxidative stress (increasing GPx, CAT, SOD), acetylcholinesterase, BACE1, and γ -secretase, and decreases A β…”
InfluentialRapid determination of theaflavins by HPLC with a new monolithic column
Zhang, J., Cui, H., Jiang, H., et al. (2019) · Czech Journal of Food Sciences · doi:10.17221/213/2018-cjfs · Cited by 10 · see citing works
Natural molecules in neuroprotection and neurotoxicity in neurodegenerative diseases
Castillo, I. L. D., Vegas‐Gomez, L., Loureiro, J. A., & Moreno‐González, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00001-4 · Cited by 3 · see citing works
Nano-based phytodrug delivery systems for the management of neurodegenerative disorders
Sudheesh, M. S., & Pawar, R. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85544-0.00001-0 · Cited by 1 · see citing works
- Authors
- Geiser, R. J., Chastain, S. E., & Moss, M. A.
- Affiliations
- University of South Carolina (US)
- ORCID
- Moss, Melissa A.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 112
- Issue
- 3
- Pages
- 362a
- ISSN
- 0006-3495 (ISSN-L)
- OpenAlex
- W2585079037
- Cited by
- 11
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2019: 2 · 2018: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, green tea catechins, amyloid-beta oligomerization, amyloid-beta, antioxidant activity, epigallocatechin gallate, epigallocatechin, epicatechin, theaflavins, amyloid hypothesis, SH-SY5Y cells, neuroprotection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
