Oral hypoglycaemic agents during pregnancy: the evidence for effectiveness and safety
Abstract
With the increase in obesity and sedentary lifestyles, the incidence of diabetes among reproductive-aged women is rising globally. Providers are expected to care for a growing number of women with gestational diabetes (GDM) in the coming decades. Traditionally, insulin has been considered the standard for management of GDM, when diet and exercise fail to achieve tight maternal glucose control without the risk of transfer of insulin across the placenta. Understanding the effectiveness and safety of the use of oral diabetes agents during pregnancy for both maternal and neonatal outcomes as an alternative management option is essential to the care of women with GDM and their offspring. In this review, our objectives were to (1) summarise the available evidence on the efficacy these medications, (2) review available data on adverse effect, (3) discuss current gaps in research, outlining limitations in current study designs that deserve attention and (4) summarise key points for the practicing clinician.
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No excess of fetal or neonatal complications could be demonstrated when the administration of metformin was compared to glyburide and insulin.
“Similarly, no excess of fetal or neonatal complications could be demonstrated when the administration of metformin was compared to glyburide and insulin(249).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [249]
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- Authors
- Nicholson, W., & Baptiste-Roberts, K.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Pennsylvania State University (US)
- Corresponding author
- Nicholson, Wanda
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 25
- Issue
- 1
- Pages
- 51-63
- ISSN
- 1521-6934 (ISSN-L)
- OpenAlex
- W2080904226
- Cited by
- 72
- References
- 35
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 13 · 2013: 13 · 2012: 8
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- oral antidiabetic drugs, gestational diabetes mellitus, pregnancy, maternal glucose control, drug safety in pregnancy, neonatal outcomes, maternal outcomes, antidiabetic efficacy, research gaps
- MeSH terms
- Administration, Oral, Female, Glyburide, Humans, Hypoglycemic Agents, Infant, Newborn, Insulin, Metformin, Pregnancy, Pregnancy Outcome, Randomized Controlled Trials as Topic, Diabetes, Gestational, Treatment Outcome, Acarbose
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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