The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
The Default Mode Network in Autism
Open accessAbstract
Autism spectrum disorder (ASD) is characterized by deficits in social communication and interaction. Since its discovery as a major functional brain system, the default mode network (DMN) has been implicated in a number of psychiatric disorders, including ASD. Here we review converging multimodal evidence for DMN dysfunction in the context of specific components of social cognitive dysfunction in ASD: ‘self-referential processing’ - the ability to process social information relative to oneself and ‘theory of mind’ or ‘mentalizing’ - the ability to infer the mental states such as beliefs, intentions, and emotions of others. We show that altered functional and structural organization of the DMN, and its atypical developmental trajectory, are prominent neurobiological features of ASD. We integrate findings on atypical cytoarchitectonic organization and imbalance in excitatory-inhibitory circuits, which alter local and global brain signaling, to scrutinize putative mechanisms underlying DMN dysfunction in ASD. Our synthesis of the extant literature suggests that aberrancies in key nodes of the DMN and their dynamic functional interactions contribute to atypical integration of information about the self in relation to ‘other’, as well as impairments in the ability to flexibly attend to socially relevant stimuli. We conclude by highlighting open questions for future research.
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BackgroundDissociable intrinsic connectivity networks for salience processing and executive control
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Self-citationCorrespondence of the brain's functional architecture during activation and rest
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Cited by
The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740
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Aphantasia and autism: An investigation of mental imagery vividness
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Pagni, B. A., Hill, E., Walsh, M. J. M., Delaney, S., Ogbeama, D., Monahan, L., Cook, J. R., Guerithault, N., Dixon, M. V., Ballard, L., et al. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220159 · Cited by 20
“For example, aberrations in within-and between-DMN connectivity in ASD 55 may have affected how the interventions were received and interacted with brain function.”
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Metadata
- Authors
- Padmanabhan, A., Lynch, C. J., Schaer, M., & Menon, V.
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 2
- Issue
- 6
- Pages
- 476-486
- ISSN
- 2451-9022 (ISSN-L)
- OpenAlex
- W2606031557
- Cited by
- 375
- References
- 142
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- green
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