The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury
Abstract
Female sex hormones are acutely neuroprotective in experimental models of traumatic brain injury (TBI). Because hormonal profiles are known to vary with estrous cycle stage, the purpose of this study was to evaluate how pre-injury estrous stage affects motor and cognitive performance after experimental TBI. We also sought to compare post-injury behavioral performance in males vs. females. Under anesthesia, male (n=18) and female (n=35) Sprague-Dawley rats underwent either controlled cortical impact (CCI) injury (2.7 mm; 4 m/s) or sham operations. Females were grouped according to estrous stage (proestrous or non-proestrous) at the time of surgery. Motor function was assessed pre-injury and for the first 5 days after surgery using beam balance and walking tasks. Spatial memory was assessed beginning 14 days post-injury utilizing the Morris water maze (MWM) task. No significant differences were found on any task between injured females regardless of estrous cycle stage. Females performed significantly better than males on both motor tasks, but gender did not influence MWM performance. Mixed effects multivariate analysis corroborated these results by showing that pre-injury serum hormone levels had little affect on behavioral performance. The results suggest that the presence of endogenous circulating hormones, rather than hormonal status at time of injury, may confer early neuroprotection in females after TBI. The impact of early neuroprotection on later behavioral outcome and the anatomic structural specificity of hormonal neuroprotection require further study.
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“Estrous stage at injury did not influence contusion volumes or behavioral outcomes in female rats. 38,61”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [38]
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Cites
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Research works printed but not linked: 1
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Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
Sex Differences in Outcome after Mild Traumatic Brain Injury
Bazarian, J. J., Blyth, B. J., Mookerjee, S., He, H., & McDermott, M. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2009.1068 · Cited by 404
Sexual dimorphism in the inflammatory response to traumatic brain injury
Villapol, S., Loane, D. J., & Burns, M. P. (2017) · Glia · doi:10.1002/glia.23171 · Cited by 320
Progesterone exerts neuroprotective effects after brain injury
Stein, D. G. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.012 · Cited by 294
Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
Bales, J. W., Wagner, A. K., Kline, A. E., & Dixon, C. E. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.011 · Cited by 272
Self-citation
Metadata
- Authors
- Wagner, A. K., Willard, L. A., Kline, A. E., Wenger, M. K., Bolinger, B. D., Ren, D., Zafonte, R. D., & Dixon, C. E.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Wagner, Amy K.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 998
- Issue
- 1
- Pages
- 113-121
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2035277900
- Cited by
- 141
- References
- 46
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 12 · 2014: 13 · 2013: 6 · 2012: 3
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (K08HD40833, R03HD41399)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, estrous cycle stage, sex differences, female sex hormones, neuroprotection, motor function, spatial memory, controlled cortical impact, serum hormone levels
- MeSH terms
- Analysis of Variance, Animals, Brain Injuries, Cognition, Disease Models, Animal, Estrogens, Female, Gender Identity, Male, Motor Activity, Progesterone, Psychomotor Performance, Reaction Time, Time Factors, Vagina, Rats, Sprague-Dawley, Maze Learning, Estrous Cycle, Rats
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