Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain
Abstract
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) and trkB both have a role in plasticity following brain insults and exercise increases BDNF and trkB mRNA levels in the normal brain. We attempted to determine whether treadmill exercise improves motor function following experimental cerebral ischemia, and whether motor outcome is associated with BDNF and trkB expression. We subjected adult male Sprague-Dawley rats to a permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. In the exercise group, improvements in the motor behavior index were found and BDNF and trkB proteins in contralateral hemisphere were increased. This study suggests that after permanent brain ischemia, exercise improves motor performance and elevates BDNF and trkB proteins in the contralateral hemisphere.
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A growing amount of data supports the hypothesis that neurotrophins constitute a neuroprotective mechanism in brain ischemia.
“Thus far, a growing amount of data supports the hypothesis that neurotrophins constitute a neuroprotective mechanism in brain ischemia (Kim et al. 2005; Wu 2005; Zhang et al. 2008).”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Kim et al. 2005
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Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain
Widenfalk, J., Olson, L., & Thorén, P. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00051-6 · Cited by 156 · see citing works
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Early Rehabilitation After Stroke: a Narrative Review
Coleman, E. R., Moudgal, R., Lang, K., Hyacinth, H. I., Awosika, O. O., Kissela, B. M., & Feng, W. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0686-6 · Cited by 424 · see citing works
MICHELSEN, K., PRICKAERTS, J., & STEINBUSCH, H. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00912-6 · Cited by 196 · see citing works
Dmitrieva, V. G., Povarova, O. V., Skvortsova, V. I., Limborska, S. A., Myasoedov, N. F., & Dergunova, L. V. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9432-0 · Cited by 54 · see citing works
Kim, K., Sung, Y.-H., Seo, J.-H., Lee, S.-W., Lim, B.-V., Lee, C.-Y., & Chung, Y.-R. (2015) · Journal of Exercise Rehabilitation · doi:10.12965/jer.150264 · Cited by 49 · see citing works
- Authors
- Kim, M.-W., Bang, M.-S., Han, T.-R., Ko, Y.-J., Yoon, B.-W., Kim, J.-H., Kang, L.-M., Lee, K.-M., & Kim, M.-H.
- Affiliations
- Catholic University of Korea (KR)
- Seoul National University (KR)
- Corresponding author
- Kim, Man-Ho
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 1052
- Issue
- 1
- Pages
- 16-21
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2023719282
- Cited by
- 113
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 6
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- treadmill exercise, brain-derived neurotrophic factor, TrkB receptor, cerebral ischemia, motor recovery, neuroplasticity, contralateral hemisphere, stroke rehabilitation, neurotrophins
- MeSH terms
- Animals, Brain, Brain Ischemia, Disease Models, Animal, Exercise Test, Gene Expression Regulation, Immunohistochemistry, Functional Laterality, Male, Motor Activity, Physical Conditioning, Animal, Time Factors, Blotting, Western, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, Infarction, Middle Cerebral Artery, Receptor, trkB, Rats
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