Cited by 49Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathologyNeuroinflammation and Neurodegeneration Mechanisms

Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats

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Kim, Kijeong, Sung, Yun-Hee, Seo, Jin-Hee, Lee, Sang-Won, Lim, Baek-Vin, Lee, Choong-Yeol, Chung, Yong-Rak·2015·Journal of Exercise Rehabilitation

Abstract

Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moderate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity exercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2'-deoxyuridine was performed to determine hippocampal cell proliferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-exposed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.

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  • Treadmill exercise in mice and aerobic exercise in humans increases BDNF expression by regulating BDNF gene expression in the hippocampus.

    “Further research has extended this to show that treadmill exercise in mice and aerobic exercise in humans increases BDNF expression by regulating BDNF gene expression in the hippocampus (Kim et al., 2015).”

    From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Kim et al., 2015

    The Results section reports increased hippocampal BDNF expression after some treadmill-exercise conditions, but the study was in rats, not mice or humans. The Methods describe a protein western blot, not a test of whether exercise regulates BDNF gene expression; the paper also does not study aerobic exercise in humans. (LLM, conf=0.90)

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Authors
Kim, K., Sung, Y.-H., Seo, J.-H., Lee, S.-W., Lim, B.-V., Lee, C.-Y., & Chung, Y.-R.
Affiliations
  • Kyungnam University (KR)
  • Baekseok University (KR)
  • Korea Military Academy (KR)
  • Dongseo University (KR)
  • Gachon University (KR)
  • Joongbu University (KR)
Corresponding author
Chung, Yong-Rak
Venue
Journal of Exercise Rehabilitation
Published
2015-12-29
Volume
11
Issue
6
Pages
296-302
ISSN
  • 2288-176X (ISSN-L)
  • 2288-1778
OpenAlex
W2210962353
Cited by
49
References
30
Citations by year
2025: 4 · 2024: 4 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 8
FWCI
1.89
Type
journal article
Language
en
Open access
Locations
  • Journal of Exercise Rehabilitation (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Research Foundation
  • National Research Foundation of Korea (2011-356-G00013)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
treadmill exercise, exercise intensity, short-term memory, maternal infection, neonatal brain injury, hippocampal neurogenesis, hippocampal cell proliferation, dentate gyrus, brain-derived neurotrophic factor, TrkB, developmental disabilities

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