Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats
Open accessAbstract
Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moderate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity exercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2'-deoxyuridine was performed to determine hippocampal cell proliferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-exposed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.
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Treadmill exercise in mice and aerobic exercise in humans increases BDNF expression by regulating BDNF gene expression in the hippocampus.
“Further research has extended this to show that treadmill exercise in mice and aerobic exercise in humans increases BDNF expression by regulating BDNF gene expression in the hippocampus (Kim et al., 2015).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Kim et al., 2015
The Results section reports increased hippocampal BDNF expression after some treadmill-exercise conditions, but the study was in rats, not mice or humans. The Methods describe a protein western blot, not a test of whether exercise regulates BDNF gene expression; the paper also does not study aerobic exercise in humans. (LLM, conf=0.90)
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- Authors
- Kim, K., Sung, Y.-H., Seo, J.-H., Lee, S.-W., Lim, B.-V., Lee, C.-Y., & Chung, Y.-R.
- Affiliations
- Kyungnam University (KR)
- Baekseok University (KR)
- Korea Military Academy (KR)
- Dongseo University (KR)
- Gachon University (KR)
- Joongbu University (KR)
- Corresponding author
- Chung, Yong-Rak
- Venue
- Journal of Exercise Rehabilitation
- Published
- 2015-12-29
- Volume
- 11
- Issue
- 6
- Pages
- 296-302
- ISSN
- 2288-176X (ISSN-L)
- 2288-1778
- PMC
- PMC4697777
- OpenAlex
- W2210962353
- Cited by
- 49
- References
- 30
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 8
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Exercise Rehabilitation (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea (2011-356-G00013)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- treadmill exercise, exercise intensity, short-term memory, maternal infection, neonatal brain injury, hippocampal neurogenesis, hippocampal cell proliferation, dentate gyrus, brain-derived neurotrophic factor, TrkB, developmental disabilities
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