Effects of melatonin on synaptic transmission and long-term potentiation in two areas of mouse hippocampus
Abstract
We have examined the effects of melatonin on synaptic transmission and long-term potentiation (LTP) in the Schaffer Collateral-CA1 and the mossy fiber-CA3 pathways in mouse hippocampus brain slices. Melatonin (0.1-1 mM) application had different actions on both the field excitatory postsynaptic potentials (fEPSPS) and LTP in the CA1 as compared to the CA3. In CA1, 0.1 mM melatonin blocked LTP, while 1 mM melatonin also depressed the fEPSP. In CA3, neither 0.1 nor 1 mM melatonin altered the fEPSP, whereas both concentrations only slightly reduced LTP. These results demonstrate that melatonin significantly alters synaptic transmission and LTP in the CA1 but has only modest actions in CA3.
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Melatonin inhibits hippocampal LTP.
“Melatonin inhibits hippocampal LTP (223,877,1171,1307)”
From About Sleep's Role in Memory (2013) · cites this paper as [877]
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- Authors
- Ozcan, M., Yilmaz, B., & Carpenter, D. O.
- Affiliations
- University at Albany, State University of New York (US)
- Corresponding author
- Carpenter, David O.
- ORCID
- Carpenter, David O.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 1111
- Issue
- 1
- Pages
- 90-94
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1992937150
- Cited by
- 49
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2020: 2 · 2019: 1 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- melatonin, long-term potentiation, synaptic transmission, hippocampus, CA1, CA3, Schaffer collateral pathway, mossy fiber pathway, field excitatory postsynaptic potentials
- MeSH terms
- Animals, Dose-Response Relationship, Drug, Hippocampus, Male, Melatonin, Mice, Inbred ICR, Neural Inhibition, Neural Pathways, Synaptic Transmission, Organ Culture Techniques, Time Factors, Presynaptic Terminals, Long-Term Potentiation, Mossy Fibers, Hippocampal, Excitatory Postsynaptic Potentials, Mice
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