Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: A Diffusion Tensor Imaging study.
Open accessAbstract
Background Autism has been hypothesized to reflect neuronal disconnection. Several recent reports implicate the key thalamic relay nuclei and cortico-thalamic connectivity in the pathophysiology of autism. Accordingly, we aimed to focus on evaluating the integrity of the thalamic radiation and sought to replicate prior white matter findings in Korean boys with high-functioning autism spectrum disorders (ASD) using Diffusion Tensor Imaging (DTI). Methods We compared fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) in 17 boys with ASD and 17 typically developing controls in the anterior thalamic radiation (ATR), superior thalamic radiation (STR), posterior thalamic radiation (PTR), corpus callosum (CC), uncinate fasciculus (UF) and inferior longitudinal fasciculus (ILF). Results The two groups were group-matched on age, IQ, handedness and head circumference. In whole-brain voxel-wise analyses, FA was significantly reduced and MD was significantly increased in the right ATR, CC, and left UF in subjects with ASD (p Conclusions Our preliminary findings support evidence implicating disturbances in the thalamo-frontal connections in autism. These findings highlight the role of hypoconnectivity between the frontal cortex and thalamus in ASD.
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An increased number of thalamocortical synapses occur in layer IV of the somatosensory cortex of 4-month-old Fmr1 KO mice.
“An increased number of thalamocortical synapses occur in layer IV of the somatosensory cortex of 4-month-old Fmr1 KO mice and altered thalamocortical connectivity is also implicated in ASD (Mizuno et al., 2006; Cheon et al., 2011; Nair et al., 2013).”
From Astrocytes in fragile X syndrome (2024) · cites this paper as Cheon et al., 2011
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256 · see citing works
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250 · see citing works
White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
Cheung, C., Chua, S. E., Cheung, V., Khong, P. L., Tai, K. S., Wong, T. K. W., Ho, T. P., & McAlonan, G. M. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02086.x · Cited by 178 · see citing works
Atypical involvement of frontostriatal systems during sensorimotor control in autism
Takarae, Y., Minshew, N. J., Luna, B., & Sweeney, J. A. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.03.008 · Cited by 171 · see citing works
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Di Martino, A., Yan, C.-G., Li, Q., Denio, E., Castellanos, F. X., Alaerts, K., Anderson, J. S., Assaf, M., Bookheimer, S. Y., Dapretto, M., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.78 · Cited by 2,780 · see citing works
Self-citationWolff, J. J., Gu, H., Gerig, G., Elison, J. T., Styner, M., Gouttard, S., Botteron, K. N., Dager, S. R., Dawson, G., Estes, A. M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11091447 · Cited by 671 · see citing works
Self-citationAltered neural connectivity in excitatory and inhibitory cortical circuits in autism
Zikopoulos, B., & Barbas, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00609 · Cited by 313 · see citing works
The implications of brain connectivity in the neuropsychology of autism
Maximo, J. O., Cadena, E. J., & Kana, R. K. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9250-0 · Cited by 259 · see citing works
Connectivity in Autism: A Review of MRI Connectivity Studies
Rane, P., Cochran, D., Hodge, S. M., Haselgrove, C., Kennedy, D. N., & Frazier, J. A. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000072 · Cited by 234 · see citing works
Functional magnetic resonance imaging of autism spectrum disorders
Dichter, G. S. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/gdichter · Cited by 215 · see citing works
Profiles of white matter tract pathology in frontotemporal dementia
Mahoney, C. J., Ridgway, G. R., Malone, I. B., Downey, L. E., Beck, J., Kinnunen, K. M., Schmitz, N., Golden, H. L., Rohrer, J. D., Schott, J. M., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22468 · Cited by 124 · see citing works
White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration
Downey, L. E., Mahoney, C. J., Buckley, A. H., Golden, H. L., Henley, S. M., Schmitz, N., Schott, J. M., Simpson, I. J., Ourselin, S., Fox, N. C., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.06.005 · Cited by 94 · see citing works
Wallingford, J., Scott, A. L., Rodrigues, K., & Doering, L. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00268 · Cited by 38 · see citing works
Astrocytes in fragile X syndrome
Talvio, K., & Castrén, M. L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1322541 · Cited by 8 · see citing works
“An increased number of thalamocortical synapses occur in layer IV of the somatosensory cortex of 4-month-old Fmr1 KO mice and altered thalamocortical connectivity is also implicated in ASD (Mizuno et al., 2006; Cheon et al., 2011; Nair et al., 2013).”
Background
- Authors
- Cheon, K.-A., Kim, Y.-S., Oh, S.-H., Park, S.-Y., Yoon, H.-W., Herrington, J., Nair, A., Koh, Y.-J., Jang, D.-P., Kim, Y.-B., Leventhal, B. L., Cho, Z.-H., Castellanos, F. X., & Schultz, R. T.
- Affiliations
- Yonsei University (KR)
- Yale University (US)
- Gachon University (KR)
- Daegu Cyber University (KR)
- Children's Hospital of Philadelphia (US)
- Hanyang University (KR)
- Nathan Kline Institute for Psychiatric Research (US)
- ORCID
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 1417
- Pages
- 77-86
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2064055424
- Cited by
- 157
- References
- 5
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 8 · 2017: 17 · 2016: 12 · 2015: 13 · 2014: 13 · 2013: 14 · 2012: 12
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Science and Technology (KRF-2008-314-E00134)
- National Research Foundation of Korea
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, high-functioning autism, anterior thalamic radiation, white matter integrity, fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity, uncinate fasciculus, inferior longitudinal fasciculus, corpus callosum, posterior thalamic radiation, thalamic relay nuclei
- MeSH terms
- Adolescent, Brain Mapping, Child, Child Development Disorders, Pervasive, Humans, Male, Neural Pathways, Thalamus, Anisotropy, Diffusion Tensor Imaging
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