Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1)
Abstract
Senescence-accelerated mouse prone (SAMP) strains of mice show early onset of senescence, whereas senescence-accelerated mouse resistant (SAMR) strains are resistant to early senescence and serve as controls. Although SAMP6 and SAMP8 are established models of central nervous system alterations, it is unclear whether SAMP1/Sku (SAMP1) is characterized by brain alterations and dysfunction related to behavioral functioning. In the present study, behavioral tests (i.e., locomotor activity, Y-maze, rotating rod, hind-limb extension, and traction), histochemistry, and Western blot analyses were employed to study this mouse model using 2- and 4-month-old SAMP1 and age-matched control SAMR1. Although 2-month-old SAMP1 and SAMR1 showed similar activity, 4-month-old SAMP1 exhibited less activity than age-matched SAMR1 in locomotor activity and Y-maze tests. In rotating rod test, 2- and 4-month-old SAMP1 showed motor-coordination dysfunction. An abnormal extension reflex in the hind-limb test was observed in 2- and 4-month-old SAMP1. There were no significant differences between SAMP1 and SAMR1 with respect to grip strength in the traction test or alternation behavior in the Y-maze test. Histochemistry and Western blot analyses exhibited that cerebellar Purkinje cells in 4-month-old SAMP1 mice persistently expressed tyrosine hydroxylase. These results suggest that SAMP1 is a useful model for examining mechanisms underlying motor dysfunction.
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Inducing accelerated senescence in a mouse model has been shown to result in motor dysfunction and cognitive decline.
“and inducing accelerated senescence in a mouse model has been shown to result in motor dysfunction and cognitive decline [5].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [5]
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- Authors
- Aoyama, Y., Yeon Kim, T., Yoshimoto, T., Niimi, K., Takahashi, E., & Itakura, C.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Takahashi, Eiki
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 1515
- Pages
- 48-54
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2081519548
- Cited by
- 14
- References
- 34
- Citations by year
- 2025: 1 · 2024: 3 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- SAMP1, SAMP8 mice, motor impairment, motor coordination, locomotor activity, Purkinje cells, tyrosine hydroxylase, cerebellum, aging
- MeSH terms
- Aging, Animals, Male, Membrane Proteins, Mice, Mutant Strains, Motor Activity, Nuclear Proteins, Maze Learning, Hindlimb Suspension, Motor Skills Disorders, Mice
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