Matrix metalloproteinases as therapeutic targets for stroke
Open accessAbstract
Matrix metalloproteinases (MMPs) are important in injury and recovery in ischemic injury. They are proteolytic enzymes that degrade all components of the extracellular matrix (ECM). They are secreted in a latent form, protecting the cell from damage, but once activated induce injury prior to rapid inactivation by four tissue inhibitors to metalloproteinases (TIMPs). Normally the constitutive enzymes, MMP-2 and membrane type MMP (MMP-14), are activated in a spatially specific manner and act close to the site of activation, while the inducible enzymes, MMP-3 and MMP-9, become active through the action of free radicals and other enzymes during neuroinflammation. Because of the complex nature of the interactions with tissues during development, injury and repair, the MMPs have multiple roles, participating in the injury process in the early stages and contributing to recovery during the later stages. This dual role complicates the planning of treatment strategies. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.
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Astrocytes secrete MMP-2 from their endfeet, and pro-MMP-9 and pro-MMP-3 are produced by endothelial cells, microglia, and pericytes.
“Astrocytes secrete MMP-2 from their endfeet, and pro–MMP-9 and pro–MMP-3 are produced by endothelial cells, microglia, and pericytes.”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [145]
TNFα and IL-1β induce expression of pro-MMP-9 and pro-MMP-3, and the latter is responsible for activating MMP-9.
“In addition, TNFα and IL-1β induce expression of pro–MMP-9 and pro–MMP-3, and the latter is responsible for activating MMP-9.”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [145]
Neutrophil extravasation into the brain parenchyma after ischemia is dependent on MMP activity.
“Neutrophil extravasation into the brain parenchyma after ischemia is dependent on MMP activity (145).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [145]
Up-regulation of hypoxia-inducible factor-1α after hypoxia leads to furin production, which activates MMP-14 that, in turn, activates MMP-2.
“Up-regulation of hypoxia-inducible factor–1α after hypoxia leads to furin production, which activates MMP-14 that, in turn, activates MMP-2.”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [145]
This combination of inflammatory events leads to tight junction and glia limitans degradation as well as leukocyte infiltration of the brain parenchyma and vasogenic edema.
“This combination of inflammatory events leads to tight junction and glia limitans degradation as well as leukocyte infiltration of the brain parenchyma and vasogenic edema (Fig. 4) (145).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [145]
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- Authors
- Yang, Y., & Rosenberg, G. A.
- Affiliations
- University of New Mexico Health Sciences Center (US)
- University of New Mexico (US)
- Corresponding author
- Rosenberg, Gary A.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 1623
- Pages
- 30-38
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC4569515
- OpenAlex
- W2016124510
- Cited by
- 246
- References
- 79
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 28 · 2023: 19 · 2022: 24 · 2021: 32 · 2020: 30 · 2019: 27 · 2018: 19 · 2017: 22 · 2016: 19 · 2015: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (RO1NS045847)
- GR, AHA (0765473Z, 10BGIA4310034)
- NIH COBRE project 7 (5P20RR015636-09)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- matrix metalloproteinases, stroke, ischemic stroke, tissue inhibitors of metalloproteinases, extracellular matrix degradation, MMP-9, MMP-2, MMP-14, MMP-3, neuroinflammation, neuroprotection, therapeutic target, tissue repair
- MeSH terms
- Animals, Brain, Humans, Stroke, Matrix Metalloproteinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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