Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
Abstract
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.
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We detected a relatively smaller number of miRNAs in CSF compared to other miRNA profiling studies.
“We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [28]
Many studies have detected extracellular/circulating miRNAs in biological fluids such as plasma, serum, cerebrospinal fluid, saliva, breast milk, urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid, and ovarian follicular fluid.
“Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [119]
Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Oncomirs — microRNAs with a role in cancer
Esquela‐Kerscher, A., & Slack, F. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1840 · Cited by 7,038 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,931 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works
RAS Is Regulated by the let-7 MicroRNA Family
Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,662 · see citing works
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257 · see citing works
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,106 · see citing works
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082 · see citing works
Univariate Discrete Distributions
(2006) · Technometrics · doi:10.1198/tech.2006.s421 · Cited by 2,001 · see citing works
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works
Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 1,751 · see citing works
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703 · see citing works
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science · doi:10.1126/science.1140481 · Cited by 1,187 · see citing works
miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection
Li, Q.-J., Chau, J., Ebert, P. J. R., Sylvester, G., Min, H., Liu, G., Braich, R. S., Manoharan, M., Soutschek, J., Skare, P., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.008 · Cited by 1,157 · see citing works
Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052 · see citing works
A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040 · see citing works
Broad Expression of Toll-Like Receptors in the Human Central Nervous System
Bsibsi, M., Ravid, R., Gveric, D. O., & van Noort, J. M. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.11.1013 · Cited by 1,000 · see citing works
Increased hippocampal neurogenesis in Alzheimer's disease
Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971 · see citing works
Sequence Variants in <i>SLITRK1</i> Are Associated with Tourette's Syndrome
Abelson, J. F., Kwan, K. Y., O'Roak, B. J., Baek, D. Y., Stillman, A. A., Morgan, T. M., Mathews, C. A., Pauls, D. L., Rašin, M.-R., Gunel, M., et al. (2005) · Science · doi:10.1126/science.1116502 · Cited by 940 · see citing works
IRS proteins and the common path to diabetes
White, M. F. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2001 · Cited by 925 · see citing works
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T. S., Goodman, R. H., & Impey, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508448102 · Cited by 799 · see citing works
Felli, N., Fontana, L., Pelosi, E., Botta, R., Bonci, D., Facchiano, F., Liuzzi, F., Lulli, V., Morsilli, O., Santoro, S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506216102 · Cited by 760 · see citing works
Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697 · see citing works
MicroRNA function: Multiple mechanisms for a tiny RNA?: FIGURE 1.
PILLAI, R. S. (2005) · RNA · doi:10.1261/rna.2248605 · Cited by 681 · see citing works
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
Lukiw, W. J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280148e8b · Cited by 662 · see citing works
Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
Bubber, P., Haroutunian, V., Fisch, G., Blass, J. P., & Gibson, G. E. (2005) · Annals of Neurology · doi:10.1002/ana.20474 · Cited by 622 · see citing works
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Krichevsky, A. M., Sonntag, K.-C., Isacson, O., & Kosik, K. S. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0441 · Cited by 574 · see citing works
Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression
Linsley, P. S., Schelter, J., Burchard, J., Kibukawa, M., Martin, M. M., Bartz, S. R., Johnson, J. M., Cummins, J. M., Raymond, C. K., Dai, H., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02005-06 · Cited by 552 · see citing works
Cell-type-specific signatures of microRNAs on target mRNA expression
Sood, P., Krek, A., Zavolan, M., Macino, G., & Rajewsky, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511045103 · Cited by 547 · see citing works
Jo, S.-H., Son, M.-K., Koh, H.-J., Lee, S.-M., Song, I.-H., Kim, Y.-O., Lee, Y.-S., Jeong, K.-S., Kim, W. B., Park, J.-W., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010120200 · Cited by 536 · see citing works
Dynamic regulation of miRNA expression in ordered stages of cellular developmentPreprint
Neilson, J. R., Zheng, G. X. Y., Burge, C. B., & Sharp, P. A. (2007) · Genes & Development · doi:10.1101/gad.1522907 · Cited by 471 · see citing works
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
Klein, M. E., Lioy, D. T., Ma, L., Impey, S., Mandel, G., & Goodman, R. H. (2007) · Nature Neuroscience · doi:10.1038/nn2010 · Cited by 444 · see citing works
Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500579102 · Cited by 401 · see citing works
Loss‐of‐function presenilin mutations in Alzheimer disease
Strooper, B. D. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400897 · Cited by 351 · see citing works
Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells
Shi, B., Sepp‐Lorenzino, L., di Prisco, M., Linsley, P. S., DeAngelis, T., & Baserga, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702806200 · Cited by 349 · see citing works
MicroRNA expression profiling of single whole embryonic stem cells
Tang, F. (2006) · Nucleic Acids Research · doi:10.1093/nar/gnj009 · Cited by 335 · see citing works
Chang, S., Ma, T. R., Miranda, R. D., Balestra, M. E., Mahley, R. W., & Huang, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508254102 · Cited by 319 · see citing works
Moschos, S. A., Williams, A. E., Perry, M. M., Birrell, M. A., Belvisi, M. G., & Lindsay, M. A. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-240 · Cited by 284 · see citing works
Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
Deo, M., Yu, J., Chung, K.-H., Tippens, M., & Turner, D. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20847 · Cited by 283 · see citing works
Engel, T., Hernández, F., Ávila, J., & Lucas, J. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0604-06.2006 · Cited by 261 · see citing works
Brain Amino Acid Requirements and Toxicity: The Example of Leucine
Yudkoff, M., Daikhin, Y., Nissim, I. B., Horyn, O., Luhovyy, B. L., Lazarow, A., & Nissim, I. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1531s · Cited by 196 · see citing works
Rosiglitazone Induces Mitochondrial Biogenesis in Mouse Brain
Strum, J. C., Shehee, R., Virley, D. J., Richardson, J. C., Mattie, M. D., Selley, P., Ghosh, S., Nock, C. M., Saunders, A. M., & Roses, A. D. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11108 · Cited by 183 · see citing works
Craft, S. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213866.86934.7e · Cited by 167 · see citing works
The Elegance of the MicroRNAs: A Neuronal Perspective
Kosik, K. S., & Krichevsky, A. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.019 · Cited by 154 · see citing works
Multiplexing RT-PCR for the detection of multiple miRNA species in small samples
Lao, K., Xu, N. L., Yeung, V., Chen, C., Livak, K. J., & Straus, N. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.106 · Cited by 150 · see citing works
Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease
Brooks, W. M., Lynch, P. J., Ingle, C. C., Hatton, A., Emson, P. C., Faull, R. L. M., & Starkey, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.106 · Cited by 148 · see citing works
Neurogenesis and brain injury: managing a renewable resource for repair
Hallbergson, A. F., Gnatenco, C., & Peterson, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20098 · Cited by 125 · see citing works
Jouvet, P. A., Rustin, P., Taylor, D. L., Pocock, J. M., Felderhoff‐Mueser, U., Mazarakis, N. D., Sarraf, C., Joashi, U. C., Kozma, M., Greenwood, K., et al. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1919 · Cited by 124 · see citing works
Watson, G. S., & Craft, S. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.08.017 · Cited by 110 · see citing works
High-throughput RNAi screening in vitro: From cell lines to primary cells
Ovcharenko, D., JARVIS, R., Hunicke‐Smith, S., Kelnar, K., & Brown, D. (2005) · RNA · doi:10.1261/rna.7288405 · Cited by 110 · see citing works
Pigino, G. F., Pelsman, A., Mori, H., & Busciglio, J. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00834.2001 · Cited by 108 · see citing works
Lotz, M., Ebert, S., Esselmann, H., Iliev, A. I., Prinz, M., Wiazewicz, N., Wiltfang, J., Gerber, J., & Nau, R. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03188.x · Cited by 105 · see citing works
Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details
Moll, N. M., Liu, L., Cardona, A. E., & Ransohoff, R. M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.09.005 · Cited by 103 · see citing works
Aksenov, M. Y., Tucker, H. M., Nair, P., Aksenova, M. V., Butterfield, D. A., Estus, S., & Markesbery, W. R. (1999) · Neurochemical Research · doi:10.1023/a:1020783614031 · Cited by 102 · see citing works
The role of the metabolic lesion in Alzheimer's disease
Blass, J. P., Gibson, G. E., & Hoyer, S. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4312 · Cited by 90 · see citing works
Mersey, B. D., Jin, P., & Danner, D. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi368 · Cited by 87 · see citing works
Immune cells may fend off Alzheimer disease
Britschgi, M., & Wyss‐Coray, T. (2007) · Nature Medicine · doi:10.1038/nm0407-408 · Cited by 60 · see citing works
Marx, J. L. (2007) · Science · doi:10.1126/science.316.5830.1416 · Cited by 51 · see citing works
Lymphocyte Development in Neonatal and Adult C-Kit-Deficient (C-Kitw/w) Mice
Waskow, C., & Prof.Dr, R. H.-R. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0757-4_1 · Cited by 32 · see citing works
Funchal, C., Rosa, A. M., Wajner, M., Wofchuk, S. T., & Pureur, R. P. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000018846.66943.30 · Cited by 28 · see citing works
Holmes, C., Dunn, N. R., Mullee, M., & Perry, V. H. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(04)80997-7 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis
Condrat, C. E., Thompson, D. C., Barbu, M. G., Bugnar, O. L., Boboc, A. E., Crețoiu, D., Suciu, N., Creţoiu, S. M., & Voinea, S. C. (2020) · Cells · doi:10.3390/cells9020276 · Cited by 1,357 · see citing works
Cheng, L., Sharples, R. A., Scicluna, B. J., & Hill, A. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23743 · Cited by 840 · see citing works
An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration
Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3113 · Cited by 697 · see citing works
Circular RNA (circRNA) in Alzheimer’s disease (AD)
Lukiw, W. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00307 · Cited by 636 · see citing works
“…or AD groups (p > 0.05, ANOVA); a dashed horizontal line at 1.0 indicates homeostatic (control) ciRS-7 levels for ease of comparison; ∗p < 0.001 (ANOVA). contribute to the down-regulation of selective miRNA-7-sensitive messenger RNA (mRNA) targets (Cogswell et al., 2008; unpublished observations).”
BackgroundInfluentialWang, T., Shao, W., Huang, Z., Tang, H., Zhang, J., Ding, Z., & Huang, K. (2021) · Nature Communications · doi:10.1038/s41467-021-23774-w · Cited by 671 · see citing works
Basic mechanisms of neurodegeneration: a critical update
Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 608 · see citing works
The Role of MicroRNAs in Human Diseases.
Ardekani, A. M., & Naeini, M. M. (2010) · Europe PMC (PubMed Central) · Cited by 552 · see citing works
Identifying and validating biomarkers for Alzheimer's disease
Humpel, C. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2010.09.007 · Cited by 484 · see citing works
Pant, S., Hilton, H., & Burczynski, M. E. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.037 · Cited by 470 · see citing works
Alteration of the microRNA network during the progression of Alzheimer's disease
Lau, P., Bossers, K., Janky, R., Salta, E., Frigerio, C. S., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201974 · Cited by 474 · see citing works
Alterations of the microRNA network cause neurodegenerative disease
Hébert, S. S., & De Strooper, B. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.003 · Cited by 452 · see citing works
Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers
Thompson, A. G., Gray, E., Heman-Ackah, S. M., Mäger, I., Talbot, K., Andaloussi, S. E., Wood, M. J., & Turner, M. R. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.68 · Cited by 431 · see citing works
Saykin, A. J., Shen, L., Foroud, T. M., Potkin, S. G., Swaminathan, S., Kim, S., Risacher, S. L., Nho, K., Huentelman, M. J., Craig, D. W., et al. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.03.013 · Cited by 442 · see citing works
Cheng, L., Doecke, J. D., Sharples, R. A., Villemagne, V. L., Fowler, C. J., Rembach, A., Martins, R. N., Rowe, C. C., Macaulay, S. L., Masters, C. L., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.127 · Cited by 409 · see citing works
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
Li, C., Ni, Y., Xu, H., Xiang, Q., Zhao, Y. Q., Zhan, J., He, J., Li, S., & Liu, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 407 · see citing works
Intercellular Transport of MicroRNAs
Boon, R. A., & Vickers, K. C. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300139 · Cited by 389 · see citing works
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works
Burgos, K., Malenica, I., Metpally, R., Courtright, A., Rakela, B., Beach, T., Shill, H., Adler, C., Sabbagh, M., Villa, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094839 · Cited by 385 · see citing works
Circulating miRNA Biomarkers for Alzheimer's Disease
Kumar, P., Dezső, Z., MacKenzie, C. J., Oestreicher, J., Agoulnik, S. I., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., & Oda, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069807 · Cited by 386 · see citing works
Finnerty, J. R., Wang, W.-X., Hébert, S. S., Wilfred, B. R., Mao, G., & Nelson, P. T. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.07.051 · Cited by 321 · see citing works
Salminen, A., Kaarniranta, K., Kauppinen, A., Ojala, J. O., Haapasalo, A., Soininen, H. S., & Hiltunen, M. O. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.002 · Cited by 366 · see citing works
Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review)
Allegra, A., Alonci, A., Campo, S., Penna, G., Petrungaro, A., Gerace, D. G., & Musolino, C. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1647 · Cited by 357 · see citing works
Systematic Review of miRNA as Biomarkers in Alzheimer’s Disease
Swarbrick, S., Wragg, N. M., Ghosh, S. K., & Stolzing, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1500-y · Cited by 353 · see citing works
Wang, W.-X., Huang, Q., Hu, Y., Stromberg, A. J., & Nelson, P. T. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0756-0 · Cited by 339 · see citing works
MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer’s disease
Banzhaf‐Strathmann, J., Benito, E., May, S., Arzberger, T., Tahirovic, S., Kretzschmar, H., Fischer, A., & Edbauer, D. (2014) · The EMBO Journal · doi:10.15252/embj.201387576 · Cited by 326 · see citing works
miR-212/132 expression and functions: within and beyond the neuronal compartment
Wanet, A., Tacheny, A., Arnould, T., & Renard, P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks151 · Cited by 331 · see citing works
miRNA malfunction causes spinal motor neuron disease
Haramati, S., Chapnik, E., Sztainberg, Y., Eilam, R., Zwang, R., Gershoni, N., McGlinn, E., Heiser, P. W., Wills, A.-M. A., Wirguin, I., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006151107 · Cited by 322 · see citing works
Hébert, S. S., Papadopoulou, A. S., Smith, P. Y., Galas, M., Planel, E., Silahtaroglu, A., Sergeant, N., Buée, L., & Strooper, B. D. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq311 · Cited by 323 · see citing works
Nunez-Iglesias, J., Liu, C.-C., Morgan, T. E., Finch, C. E., & Zhou, X. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008898 · Cited by 320 · see citing works
miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model
Lee, S., Chu, K., Jung, K., Kim, J. H., Huh, J., Yoon, H., Park, D., Lim, J., Kim, J., Jeon, D., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23588 · Cited by 275 · see citing works
MicroRNAs in Alzheimer’s Disease
Wang, M., Qin, L., & Tang, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00153 · Cited by 307 · see citing works
Baraniskin, A., Kuhnhenn, J., Schlegel, U. S., Chan, A., Deckert, M., Gold, R., Maghnouj, A., Zöllner, H., Reinacher‐Schick, A., Schmiegel, W., et al. (2011) · Blood · doi:10.1182/blood-2010-09-308684 · Cited by 303 · see citing works
Teplyuk, N. M., Mollenhauer, B., Gabriely, G., Giese, A., Kim, E. L., Smolsky, M., Kim, R. Y., Saria, M. G., Pastorino, S., Kesari, S. P., et al. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos074 · Cited by 302 · see citing works
Murillo, O. D., Thistlethwaite, W., Rozowsky, J. S., Subramanian, S. L., Lucero, R., Shah, N., Jackson, A. R., Srinivasan, S., Chung, A. Y., Laurent, C. D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.018 · Cited by 300 · see citing works
miR-9: a versatile regulator of neurogenesis
Coolen, M., Katz, S., & Bally-Cuif, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00220 · Cited by 286 · see citing works
Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
Geekiyanage, H., Jicha, G. A., Nelson, P. T., & Chan, C. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.026 · Cited by 292 · see citing works
Wong, H. K., Veremeyko, T., Patel, N., Lemere, C. A., Walsh, D. M., Esau, C., Vanderburg, C. R., & Krichevsky, A. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt164 · Cited by 293 · see citing works
Epigenetic principles and mechanisms underlying nervous system functions in health and disease
Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 292 · see citing works
Absalon, S., Kochanek, D. M., Raghavan, V., & Krichevsky, A. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1327-13.2013 · Cited by 259 · see citing works
High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA
Mestdagh, P., Feys, T., Bernard‐Marissal, N., Guenther, S. M., Chen, C., Speleman, F., & Vandesompele, J. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn725 · Cited by 288 · see citing works
Human Traumatic Brain Injury Alters Plasma microRNA Levels
Redell, J. B., Moore, A. N., Ward, N. H., Hergenroeder, G. W., & Dash, P. K. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1481 · Cited by 282 · see citing works
Recent advances in our understanding of neurodegeneration
Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works
MicroRNAs shape the neuronal landscape
McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274 · see citing works
MicroRNAs: Roles in Regulating Neuroinflammation
Gaudet, A. D., Fonken, L. K., Watkins, L. R., Nelson, R. J., & Popovich, P. G. (2017) · The Neuroscientist · doi:10.1177/1073858417721150 · Cited by 270 · see citing works
Banigan, M. G., Kao, P. F., Kozubek, J. A., Winslow, A. R., Medina, J., Costa, J., Schmitt, A., Schneider, A., Cabral, H., Cagsal‐Getkin, O., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0048814 · Cited by 267 · see citing works
Kim, A. H., Reimers, M., Maher, B., Williamson, V., McMichael, O., McClay, J. L., van den Oord, E. J. C. G., Riley, B. P., Kendler, K. S., & Vladimirov, V. I. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.002 · Cited by 298 · see citing works
Analytical aspects of microRNA in diagnostics: A review
Planell-Saguer, M. D., & Rodicio, M. C. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.05.025 · Cited by 259 · see citing works
Non-Coding RNAs: Multi-Tasking Molecules in the Cell
Gomes, A. Q., Nolasco, S., & Soares, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816010 · Cited by 261 · see citing works
Epigenetic mechanisms in Alzheimer's disease
Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C. M., Coleman, P. D., & Rogers, J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.017 · Cited by 258 · see citing works
Geekiyanage, H., & Chan, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3883-11.2011 · Cited by 254 · see citing works
Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
van den Berg, M. M. J., Krauskopf, J., Ramaekers, J. G., Kleinjans, J. C. S., Prickaerts, J., & Briedé, J. J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101732 · Cited by 253 · see citing works
The emerging role of microRNAs in Alzheimer's disease
Femminella, G. D., Ferrara, N., & Rengo, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00040 · Cited by 270 · see citing works
miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database
Kehl, T., Kern, F., Backes, C., Fehlmann, T., Stöckel, D., Meese, E. U., Lenhof, H., & Keller, A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1022 · Cited by 244 · see citing works
The involvement of microRNAs in neurodegenerative diseases
Maciotta, S., Meregalli, M., & Torrente, Y. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00265 · Cited by 247 · see citing works
Non-coding RNAs with essential roles in neurodegenerative disorders
Salta, E., & Strooper, B. D. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70286-1 · Cited by 244 · see citing works
Shi, H., Xu, J., Zhang, G., Xu, L., Li, C., Wang, L., Zhao, Z., Jiang, W., Guo, Z., & Li, X. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-101 · Cited by 240 · see citing works
MicroRNA-101 Regulates Amyloid Precursor Protein Expression in Hippocampal Neurons
Vilardo, E., Barbato, C., Ciotti, M., Cogoni, C., & Ruberti, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.112664 · Cited by 238 · see citing works
MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
Denk, J., Boelmans, K., Siegismund, C., Lassner, D., Arlt, S., & Jahn, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126423 · Cited by 236 · see citing works
Müller, M., Kuiperij, H. B., Claassen, J. A. H. R., Küsters, B., & Verbeek, M. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.005 · Cited by 234 · see citing works
Gardiner, E. J., Beveridge, N. J., Wu, J. Q., Carr, V. J., Scott, R. J., Tooney, P. A., & Cairns, M. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.78 · Cited by 232 · see citing works
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
Smith, P. Y., Hernandez-Rapp, J., Jolivette, F., Lecours, C., Bisht, K., Goupil, C., Dorval, V., Parsi, S., Morin, F., Planel, E., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv377 · Cited by 233 · see citing works
Circular RNA and Alzheimer’s Disease
Akhter, R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_19 · Cited by 231 · see citing works
Vella, L. J., Hill, A. F., & Cheng, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020173 · Cited by 231 · see citing works
MicroRNA Expression Aberration as Potential Peripheral Blood Biomarkers for Schizophrenia
Lai, C.-Y., Yu, S.-L., Hsieh, M. H., Chen, C.-H., Chen, H.-Y., Wen, C.-C., Huang, Y.-H., Hsiao, P.-C., Hsiao, C. K., Liu, C.-M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021635 · Cited by 228 · see citing works
Self-citationMiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study
Nelson, P. T., & Wang, W.-X. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091603 · Cited by 222 · see citing works
Circulating miRNAs as Potential Biomarkers in Alzheimer's Disease
Galimberti, D., Villa, C., Fenoglio, C., Serpente, M., Ghezzi, L., Cioffi, S. M. G., Arighi, A., Fumagalli, G., & Scarpini, E. (2014) · Journal of Alzheimer’s Disease · doi:10.3233/jad-140756 · Cited by 222 · see citing works
Circulating miR-125b as a biomarker of Alzheimer's disease
Tan, L., Yu, J., Liu, Q.-Y., Tan, M., Zhang, W., Hu, N., Wang, Y.-L., Sun, L., Jiang, T., & Tan, L. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.10.002 · Cited by 222 · see citing works
MicroRNAs in neurodegenerative diseases and their therapeutic potential
Junn, E., & Mouradian, M. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.002 · Cited by 222 · see citing works
Ye, Y., Wang, K. K., Gu, J. H., Yang, H., Lin, J. M., Ajani, J. A., & Wu, X. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0135 · Cited by 222 · see citing works
MicroRNAs as biomarkers for CNS disease
Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 226 · see citing works
miR‐155 as a multiple sclerosis–relevant regulator of myeloid cell polarization
Moore, C. S., Rao, V. T. S., Durafourt, B. A., Bedell, B. J., Ludwin, S. K., Bar‐Or, A., & Antel, J. P. (2013) · Annals of Neurology · doi:10.1002/ana.23967 · Cited by 219 · see citing works
MicroRNA regulation of homeostatic synaptic plasticity
Cohen, J. E., Lee, P. R., Chen, S., Li, W., & Fields, R. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017576108 · Cited by 214 · see citing works
microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches
Leggio, L., Vivarelli, S., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Marchetti, B., & Iraci, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122698 · Cited by 216 · see citing works
MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders
Maes, O. C., Chertkow, H. M., Wang, E., & Schipper, H. M. (2009) · Current Genomics · doi:10.2174/138920209788185252 · Cited by 217 · see citing works
Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease
Dong, H., Li, J., Huang, L., Chen, X., Li, D., Wang, T., Hu, C., Xu, J. L., Zhang, C., Zen, K., et al. (2015) · Disease Markers · doi:10.1155/2015/625659 · Cited by 214 · see citing works
Adlakha, Y. K., & Saini, N. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-33 · Cited by 213 · see citing works
MicroRNAs in Plasma and Cerebrospinal Fluid as Potential Markers for Alzheimer's Disease
Kiko, T., Nakagawa, K., Tsuduki, T., Furukawa, K., Arai, H., & Miyazawa, T. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-130932 · Cited by 256 · see citing works
Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β
Schonrock, N., Ke, Y. D., Humphreys, D., Staufenbiel, M., Ittner, L. M., Preiss, T., & Götz, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011070 · Cited by 211 · see citing works
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
Smith, P. Y., Hashimi, A. A., Girard, J., Delay, C., & Hébert, S. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07097.x · Cited by 209 · see citing works
Circulating miRNAs as Biomarkers for Neurodegenerative Disorders
Grasso, M., Piscopo, P., Confaloni, A., & Denti, M. (2014) · Molecules · doi:10.3390/molecules19056891 · Cited by 187 · see citing works
MicroRNA dysregulation in schizophrenia
Beveridge, N. J., & Cairns, M. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.029 · Cited by 206 · see citing works
Cao, D., Li, L., & Chan, W. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060842 · Cited by 203 · see citing works
Santa‐María, I., Alaniz, M. E., Renwick, N. M., Cela, C., Fulga, T. A., Vactor, D. V., Tuschl, T., Clark, L. N., Shelanski, M. L., McCabe, B. D., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78421 · Cited by 202 · see citing works
Long, J. M., Ray, B., & Lahiri, D. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366336 · Cited by 198 · see citing works
Kumar, L., Shamsuzzama, S., Haque, R., Baghel, T., & Nazir, A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0213-8 · Cited by 201 · see citing works
Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies
Pardini, B., Sabo, A. A., Birolo, G., & Calin, G. A. (2019) · Cancers · doi:10.3390/cancers11081170 · Cited by 198 · see citing works
Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing
Burgos, K., Javaherian, A., Bomprezzi, R., Ghaffari, L., Rhodes, S. N., Courtright-Lim, A., Tembe, W., Kim, S., Metpally, R. P. R., & Keuren‐Jensen, K. R. V. (2013) · RNA · doi:10.1261/rna.036863.112 · Cited by 191 · see citing works
Long, J. M., Ray, B., & Lahiri, D. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.518241 · Cited by 187 · see citing works
Plasma microRNA biomarkers for detection of mild cognitive impairment
Sheinerman, K. S., Tsivinsky, V. G., Crawford, F., Mullan, M. J., Abdullah, L., & Umansky, S. R. (2012) · Aging · doi:10.18632/aging.100486 · Cited by 158 · see citing works
Epigenetics of Alzheimer’s Disease
Perković, M. N., Paska, A. V., Konjevod, M., Kouter, K., Štrac, D. Š., Erjavec, G. N., & Pivac, N. (2021) · Biomolecules · doi:10.3390/biom11020195 · Cited by 181 · see citing works
Peripheral whole blood microRNA alterations in major depression and bipolar disorder
Maffioletti, E., Cattaneo, A., Rosso, G., Maina, G., Maj, C., Gennarelli, M., Tardito, D., & Bocchio-Chiavetto, L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.021 · Cited by 181 · see citing works
NeurimmiRs: microRNAs in the neuroimmune interface
Soreq, H., & Wolf, Y. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.06.009 · Cited by 183 · see citing works
miEAA: microRNA enrichment analysis and annotation
Backes, C., Khaleeq, Q. T., Meese, E. U., & Keller, A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw345 · Cited by 178 · see citing works
Vallelunga, A., Ragusa, M., Mauro, S. D., Iannitti, T., Pilleri, M., Biundo, R., Weis, L., Pietro, C. D., Iuliis, A. D., Nicoletti, A. S. Q., et al. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00156 · Cited by 175 · see citing works
Gámez‐Valero, A., Campdelacreu, J., Vilas, D., Ispierto, L., Reñé, R., Álvarez, R., Armengol, M. P., Borràs, F. E., & Beyer, K. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0169-5 · Cited by 176 · see citing works
Genomic integrity and the ageing brain
Chow, H.-M., & Herrup, K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4020 · Cited by 174 · see citing works
Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease
Martins, T. S., Trindade, D., Vaz, M., Campelo, I., Almeida, M., Trigo, G., Silva, O. A. B. D. C. E., & Henriques, A. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15112 · Cited by 174 · see citing works
MicroRNAs in Alzheimer's disease
Delay, C., Mandemakers, W., & Hébert, S. S. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.003 · Cited by 185 · see citing works
Non-coding RNAs in Alzheimer's Disease
Tan, L., Yu, J.-T., Hu, N., & Tan, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8359-5 · Cited by 171 · see citing works
- Authors
- Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Asuragen (United States) (US)
- Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W32204808
- Cited by
- 943
- References
- 65
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- National Institute on Aging (NIA AG05128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, microRNA
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor
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