Cited by 945MicroRNA in disease regulationAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

Cogswell, John P., Ward, James, Taylor, Ian A., Waters, Michelle, Shi, Yunling, Cannon, Brian, Kelnar, Kevin, Kemppainen, Jon +7 more·2008·Journal of Alzheimer s Disease

Abstract

MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.

Integrity signals

Registry

Crossref · 10.3233/jad-2008-14103

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64 of 64 references verified0 citation errors · 0 not checkable

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  • We detected a relatively smaller number of miRNAs in CSF compared to other miRNA profiling studies.

    “We detected a relatively smaller number of miRNAs in CSF, compared to other miRNA profiling studies19,28.”
  • Many studies have detected extracellular/circulating miRNAs in biological fluids such as plasma, serum, cerebrospinal fluid, saliva, breast milk, urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid, and ovarian follicular fluid.

    “Many studies have detected extracellular/circulating miRNAs in biological fluids, such as plasma and serum (117, 118), cerebrospinal fluid (119), saliva (120), breast milk (121), urine, tears, colostrum, peritoneal fluid, bronchial lavage, seminal fluid (122), and ovarian follicular fluid (123).”

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Authors
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., Prinjha, R. K., Richardson, J. C., Saunders, A. M., Roses, A. D., & Richards, C. A.
Affiliations
  • GlaxoSmithKline (United States) (US)
  • Asuragen (United States) (US)
  • Molecular Cell Biology-RandD, Applied Biosystems Foster City, CA, USA
  • GlaxoSmithKline (United Kingdom) (GB)
Venue
Journal of Alzheimer s Disease
Published
2008-05-09
Volume
14
Issue
1
Pages
27-41
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W32204808
Cited by
943
References
65
Citations by year
2026: 15 · 2025: 32 · 2024: 28 · 2023: 35 · 2022: 50 · 2021: 78 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 65 · 2016: 64 · 2015: 83 · 2014: 71 · 2013: 74 · 2012: 50
FWCI
12.06
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • GlaxoSmithKline
  • National Institute on Aging (NIA AG05128)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, microRNA
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Cerebellum, Female, Frontal Lobe, Gene Expression Regulation, Genetic Markers, Hippocampus, Humans, Immunity, Innate, Insulin Resistance, Male, Middle Aged, Neurons, RNA, Messenger, Transfection, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Cell Line, Tumor

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