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Cited by 226Psychedelics and Drug StudiesAlkaloids: synthesis and pharmacologySynthesis and bioactivity of alkaloids

The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.

Ayahuasca: Pharmacology, neuroscience and therapeutic potential

Domínguez-Clavé, Elisabet, Soler, Joaquim, Elices, Matilde, Pascual, Juan C., Álvarez, Enrique, de la Fuente Revenga, Mario, Friedlander, Pablo, Feilding, Amanda, Riba, Jordi·2016·Brain Research Bulletin
DOI 10.1016/j.brainresbull.2016.03.002
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Abstract

Ayahuasca is the Quechua name for a tea obtained from the vine Banisteriopsis caapi, and used for ritual purposes by the indigenous populations of the Amazon. The use of a variation of the tea that combines B. caapi with the leaves of the shrub Psychotria viridis has experienced unprecedented expansion worldwide for its psychotropic properties. This preparation contains the psychedelic 5-HT 2A receptor agonist N,N-dimethyltryptamine (DMT) from P. viridis, plus β-carboline alkaloids with monoamine-oxidase-inhibiting properties from B. caapi. Acute administration induces a transient modified state of consciousness characterized by introspection, visions, enhanced emotions and recollection of personal memories. A growing body of evidence suggests that ayahuasca may be useful to treat substance use disorders, anxiety and depression. Here we review the pharmacology and neuroscience of ayahuasca, and the potential psychological mechanisms underlying its therapeutic potential. We discuss recent findings indicating that ayahuasca intake increases certain mindfulness facets related to acceptance and to the ability to take a detached view of one's own thoughts and emotions. Based on the available evidence, we conclude that ayahuasca shows promise as a therapeutic tool by enhancing self-acceptance and allowing safe exposure to emotional events. We postulate that ayahuasca could be of use in the treatment of impulse-related, personality and substance use disorders and also in the handling of trauma. More research is needed to assess the full potential of ayahuasca in the treatment of these disorders.

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Crossref · 10.1016/j.brainresbull.2016.03.002

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Metadata

Authors
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J.
Affiliations
  • Universitat Autònoma de Barcelona (ES)
  • Beckley Foundation (GB)
ORCID
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
2016-09
Volume
126
Issue
Pt 1
Pages
89-101
ISSN
0361-9230 (ISSN-L)
DOI
10.1016/j.brainresbull.2016.03.002
OpenAlex
W2301686735
Cited by
226
References
139
Citations by year
2026: 17 · 2025: 27 · 2024: 22 · 2023: 16 · 2022: 29 · 2021: 28 · 2020: 29 · 2019: 18 · 2018: 25 · 2017: 9 · 2016: 4
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and bioactivity of alkaloids
Keywords
ayahuasca, Banisteriopsis caapi, Psychotria viridis, N,N-dimethyltryptamine, β-carbolines, monoamine oxidase inhibition, psychedelics, altered states of consciousness, substance use disorders, anxiety, depression, mindfulness, self-acceptance, trauma, personality disorders, impulse control disorders, therapeutic potential
MeSH terms
Animals, Carbolines, Humans, Neurosciences, Pharmacology, Plant Extracts, Banisteriopsis

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