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Cited by 111Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 147 of the 151 references it cites were found in a registry or an index.

The role of cortical inhibition in the pathophysiology and treatment of schizophrenia

Daskalakis, Zafiris J., Fitzgerald, Paul B., Christensen, Bruce K.·2007·Brain Research Reviews
DOI 10.1016/j.brainresrev.2007.09.006
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Abstract

Dysfunctional cortical inhibition (CI) has been suggested as a mechanism through which symptoms of schizophrenia (SCZ) are mediated. Cortical inhibition refers to a neurophysiological process in which gamma-aminobutyric acid (GABA) inhibitory interneurons selectively attenuate the activity of other neurons (e.g., pyramidal neurons) in the cortex. Here we review the neuroanatomic and neurophysiological evidence suggesting CI deficits among persons with SCZ. We also review genetic studies that have linked CI deficits to a polymorphism in the alpha(7)-nicotinic cholinergic receptor, thereby positing that a specific genetic mechanism underlies SCZ-related GABA interneuron dysfunction. We will conclude by reviewing the role of CI as a mechanism mediating the therapeutic action of antipsychotic medications.

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Crossref · 10.1016/j.brainresrev.2007.09.006

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Citations

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Show all 151 references

Research works printed but not linked: 5

  1. Benes, 1997, Differential distribution of tyrosine hydroxylase fibers on small and large neurons in layer II of anterior cingulate cortex of schizophrenic brain, Synapse, 25, 80, 10.1002/(SICI)1098-2396(199701)25:1<80::AID-SYN10>3.0.CO;2-2 · DOI
  2. Javitt, 2006, Role of NMDA and GABAB receptors in cortical and subcortical dopaminergic regulation, vol. 31, S47
  3. Leonard, 1998, Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative, Am. J. Med. Genet., 81, 308, 10.1002/(SICI)1096-8628(19980710)81:4<308::AID-AJMG6>3.0.CO;2-P · DOI
  4. Stassen, 2000, Schizophrenia and smoking: evidence for a common neurobiological basis?, Am. J. Med. Genet., 96, 173, 10.1002/(SICI)1096-8628(20000403)96:2<173::AID-AJMG10>3.0.CO;2-U · DOI
  5. Ziemann, 1996, Impaired motor cortex inhibition in patients with Parkinson's disease and other parkinsonian syndromes. A transcranial magnetic stimulation study [abstract], Mov. Disord., 11, 72

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Metadata

Authors
Daskalakis, Z. J., Fitzgerald, P. B., & Christensen, B. K.
Affiliations
  • Centre for Addiction and Mental Health (CA)
  • The Alfred Hospital (AU)
Corresponding author
Daskalakis, Zafiris J.
ORCID
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2007-12
Volume
56
Issue
2
Pages
427-442
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/j.brainresrev.2007.09.006
OpenAlex
W2083937777
Cited by
111
References
151
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 9
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
cortical inhibition, schizophrenia, GABAergic interneurons, alpha7 nicotinic acetylcholine receptor, genetic polymorphism, antipsychotic mechanism of action, pyramidal neurons, schizophrenia pathophysiology, schizophrenia treatment
MeSH terms
Animals, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Interneurons, Schizophrenia, Glutamic Acid

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