Cited by 111Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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The role of cortical inhibition in the pathophysiology and treatment of schizophrenia

Daskalakis, Zafiris J., Fitzgerald, Paul B., Christensen, Bruce K.·2007·Brain Research Reviews

DOI 10.1016/j.brainresrev.2007.09.006

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Abstract

Dysfunctional cortical inhibition (CI) has been suggested as a mechanism through which symptoms of schizophrenia (SCZ) are mediated. Cortical inhibition refers to a neurophysiological process in which gamma-aminobutyric acid (GABA) inhibitory interneurons selectively attenuate the activity of other neurons (e.g., pyramidal neurons) in the cortex. Here we review the neuroanatomic and neurophysiological evidence suggesting CI deficits among persons with SCZ. We also review genetic studies that have linked CI deficits to a polymorphism in the alpha(7)-nicotinic cholinergic receptor, thereby positing that a specific genetic mechanism underlies SCZ-related GABA interneuron dysfunction. We will conclude by reviewing the role of CI as a mechanism mediating the therapeutic action of antipsychotic medications.

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Authors: Daskalakis, Z. J., Fitzgerald, P. B., & Christensen, B. K.
Affiliations: Centre for Addiction and Mental Health (CA)
The Alfred Hospital (AU)
Corresponding author: Daskalakis, Zafiris J.
ORCID: Daskalakis, Zafiris J.
Fitzgerald, Paul B.
Christensen, Bruce K.
Venue: Brain Research Reviews
Publisher: Elsevier BV
Published: 2007-12
Volume: 56
Issue: 2
Pages: 427-442
ISSN: 0165-0173 (ISSN-L)
DOI: 10.1016/j.brainresrev.2007.09.006
OpenAlex: W2083937777
Cited by: 111
References: 151
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 9
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: cortical inhibition, schizophrenia, GABAergic interneurons, alpha7 nicotinic acetylcholine receptor, genetic polymorphism, antipsychotic mechanism of action, pyramidal neurons, schizophrenia pathophysiology, schizophrenia treatment
MeSH terms: Animals, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Interneurons, Schizophrenia, Glutamic Acid

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The role of cortical inhibition in the pathophysiology and treatment of schizophrenia

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