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Cited by 209Digital Mental Health InterventionsMultiple Sclerosis Research StudiesCancer survivorship and care

The DOI matches its Crossref record; 26 of the 28 references it cites were found in a registry or an index.

A pilot randomised controlled trial of an Internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue

Moss-Morris, Rona, McCrone, Paul, Yardley, Lucy, van Kessel, Kirsten, Wills, Gary, Dennison, Laura·2012·Behaviour Research and Therapy
DOI 10.1016/j.brat.2012.03.001
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Abstract

The majority of people affected by Multiple Sclerosis (paMS) experience severe and disabling fatigue. A recent randomised controlled trial (RCT) showed that cognitive behaviour therapy with a clinical psychologist was an effective treatment for MS fatigue. An Internet-based version of this intervention, MS Invigor8, was developed for the current study using agile design and input from paMS. MS Invigor8 includes eight tailored, interactive sessions. The aim was to test the feasibility and potential efficacy and cost-effectiveness of the programme in a pilot RCT. 40 patients were randomised to MS Invigor8 (n=23) or standard care (n=17). The MS Invigor8 group accessed sessions over 8-10 weeks and received up to three 30-60min telephone support sessions. Participants completed online standardised questionnaires assessing fatigue, mood, quality of life and service use at baseline and 10 weeks follow-up. Large between group treatment effects were found for the primary outcomes of fatigue severity (d=1.19) and impact (d=1.02). The MS Invigor8 group also reported significantly greater improvements in anxiety, depression and quality-adjusted life years. These data suggest that Internet-based CBT may be a clinically and cost-effective treatment for MS fatigue. A larger RCT with longer term follow-up is warranted.

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Metadata

Authors
Moss-Morris, R., McCrone, P., Yardley, L., van Kessel, K., Wills, G., & Dennison, L.
Affiliations
  • Guy's Hospital (GB)
  • King's College London (GB)
  • University of Southampton (GB)
Corresponding author
Moss-Morris, Rona
ORCID
Venue
Behaviour Research and Therapy
Publisher
Elsevier BV
Published
2012-06
Volume
50
Issue
6
Pages
415-421
ISSN
0005-7967 (ISSN-L)
DOI
10.1016/j.brat.2012.03.001
OpenAlex
W2068642589
Cited by
209
References
28
Citations by year
2026: 8 · 2025: 18 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 28 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 18 · 2013: 3 · 2012: 1
FWCI
16.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behaviour Research and Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (acceptedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Multiple Sclerosis Society
Topics
  • Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords
multiple sclerosis, fatigue, cognitive behavioral therapy, online intervention, self-management program, feasibility, cost-effectiveness, anxiety, depression, quality of life, telephone support
MeSH terms
Adult, Cost-Benefit Analysis, Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Patient Compliance, Pilot Projects, Quality of Life, Self Care, Cognitive Behavioral Therapy, Treatment Outcome, Patient Satisfaction, Remote Consultation, Internet

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