Cited by 209Digital Mental Health InterventionsMultiple Sclerosis Research StudiesCancer survivorship and care

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A pilot randomised controlled trial of an Internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue

Moss-Morris, Rona, McCrone, Paul, Yardley, Lucy, van Kessel, Kirsten, Wills, Gary, Dennison, Laura·2012·Behaviour Research and Therapy

DOI 10.1016/j.brat.2012.03.001

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Abstract

The majority of people affected by Multiple Sclerosis (paMS) experience severe and disabling fatigue. A recent randomised controlled trial (RCT) showed that cognitive behaviour therapy with a clinical psychologist was an effective treatment for MS fatigue. An Internet-based version of this intervention, MS Invigor8, was developed for the current study using agile design and input from paMS. MS Invigor8 includes eight tailored, interactive sessions. The aim was to test the feasibility and potential efficacy and cost-effectiveness of the programme in a pilot RCT. 40 patients were randomised to MS Invigor8 (n=23) or standard care (n=17). The MS Invigor8 group accessed sessions over 8-10 weeks and received up to three 30-60min telephone support sessions. Participants completed online standardised questionnaires assessing fatigue, mood, quality of life and service use at baseline and 10 weeks follow-up. Large between group treatment effects were found for the primary outcomes of fatigue severity (d=1.19) and impact (d=1.02). The MS Invigor8 group also reported significantly greater improvements in anxiety, depression and quality-adjusted life years. These data suggest that Internet-based CBT may be a clinically and cost-effective treatment for MS fatigue. A larger RCT with longer term follow-up is warranted.

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Authors: Moss-Morris, R., McCrone, P., Yardley, L., van Kessel, K., Wills, G., & Dennison, L.
Affiliations: Guy's Hospital (GB)
King's College London (GB)
University of Southampton (GB)
Corresponding author: Moss-Morris, Rona
ORCID: Moss-Morris, Rona
McCrone, Paul
Yardley, Lucy
Wills, Gary
Venue: Behaviour Research and Therapy
Publisher: Elsevier BV
Published: 2012-06
Volume: 50
Issue: 6
Pages: 415-421
ISSN: 0005-7967 (ISSN-L)
DOI: 10.1016/j.brat.2012.03.001
OpenAlex: W2068642589
Cited by: 209
References: 28
Citations by year: 2026: 8 · 2025: 18 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 28 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 18 · 2013: 3 · 2012: 1
FWCI: 16.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behaviour Research and Therapy (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Multiple Sclerosis Society
Topics: Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords: multiple sclerosis, fatigue, cognitive behavioral therapy, online intervention, self-management program, feasibility, cost-effectiveness, anxiety, depression, quality of life, telephone support
MeSH terms: Adult, Cost-Benefit Analysis, Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Patient Compliance, Pilot Projects, Quality of Life, Self Care, Cognitive Behavioral Therapy, Treatment Outcome, Patient Satisfaction, Remote Consultation, Internet

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A pilot randomised controlled trial of an Internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue

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