The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Non-invasive Vagus Nerve Stimulation in Healthy Humans Reduces Sympathetic Nerve Activity
Open accessAbstract
BACKGROUND Vagus nerve stimulation (VNS) is currently used to treat refractory epilepsy and is being investigated as a potential therapy for a range of conditions, including heart failure, tinnitus, obesity and Alzheimer's disease. However, the invasive nature and expense limits the use of VNS in patient populations and hinders the exploration of the mechanisms involved. OBJECTIVE We investigated a non-invasive method of VNS through electrical stimulation of the auricular branch of the vagus nerve distributed to the skin of the ear--transcutaneous VNS (tVNS) and measured the autonomic effects. METHODS The effects of tVNS parameters on autonomic function in 48 healthy participants were investigated using heart rate variability (HRV) and microneurography. tVNS was performed using a transcutaneous electrical nerve stimulation (TENS) machine and modified surface electrodes. Participants visited the laboratory once and received either active (200 μs, 30 Hz; n = 34) or sham (n = 14) stimulation. RESULTS Active tVNS significantly increased HRV in healthy participants (P = 0.026) indicating a shift in cardiac autonomic function toward parasympathetic predominance. Microneurographic recordings revealed a significant decrease in frequency (P = 0.0001) and incidence (P = 0.0002) of muscle sympathetic nerve activity during tVNS. CONCLUSION tVNS can increase HRV and reduce sympathetic nerve outflow, which is desirable in conditions characterized by enhanced sympathetic nerve activity, such as heart failure. tVNS can therefore influence human physiology and provide a simple and inexpensive alternative to invasive VNS.
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Cites
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Cited by
Yap, J. Y. Y., Keatch, C., Lambert, E., Woods, W., Stoddart, P. R., & Kameneva, T. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00284 · Cited by 432
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Breath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity
Gerritsen, R. J. S., & Band, G. P. H. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00397 · Cited by 342
“Multiple studies and reviews show an increase of PNS activity, and some also show a decrease of SNS activity (Popov et al., 2013; Clancy et al., 2014; Murray et al., 2016; Zhou et al., 2016).”
BackgroundClinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics
Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P., Esler, M., De Ferrari, G. M., Fishbein, M. C., Goldberger, J. J., Harper, R. M., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271870 · Cited by 308
Koenig, J., Kemp, A. H., Beauchaine, T. P., Thayer, J. F., & Kaess, M. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.04.013 · Cited by 285
Metadata
- Authors
- Clancy, J. A., Mary, D. A., Witte, K. K., Greenwood, J. P., Deuchars, S. A., & Deuchars, J.
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 7
- Issue
- 6
- Pages
- 871-877
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W2153124866
- Cited by
- 539
- References
- 12
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- green
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