Mechanical Affective Touch Therapy (MATT) for Anxiety Disorders: Effects on Resting State Functional Connectivity
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induced changes.This is a within-subjects randomized, double-blind, cross-over study, where subjects were administered on separate sessions: carbamazepine (Na + channel blocker), nimodipine (Ca 2+ channel blocker), lorazepam (GABA A receptor positive allosteric modulator), dextromethorphan (NMDA receptor antagonist), or placebo.In each session, participants take the drug and after 1.5 hours, they participate in online coupled TUS-TMS stimulation, where TMS is delivered at the last 10 ms of a 500 ms TUS sonication over M1.This is followed by delivery of a thetaburst TUS over M1, where pre-stimulation TMS measures are compared offline to post-stimulation measures at several timepoints.The effects of the pharmacological agents on TUS-induced plasticity are compared to that of placebo.This study will elucidate the mechanisms of TUS neuromodulation in the human motor cortex.This will be a crucial step in the development of TUS as a novel non-invasive treatment for neurological and psychiatric disorders.We intend to present preliminary data of our study at the conference.
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Improvements in interoceptive sensibility following these practices are associated with increasing insula responsiveness and reductions in anxiety and depressive symptoms.
“Improvements in interoceptive sensibility following these practices are associated with increasing insula responsiveness and reductions in anxiety and depressive symptoms [65–67], highlighting a potential mediatory role.”
From Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis (2026) · cites this paper as [66]
The P2.008 MATT abstract (page not specified) reports increased insula connectivity after an initial session and says other connectivity changes correlated with decreased stress. It does not report improvements in interoceptive sensibility or establish that increased insula responsiveness was associated with reductions in both anxiety and depressive symptoms. (LLM, conf=0.85)
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Wang, Y., Li, Q., Xue, X., Xu, X., Tao, W., Liu, S., Li, Y., Wang, H., & Hua, Y. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1096930 · Cited by 6 · see citing works
Bednarek, L., Harrison, B. J., Davey, C. G., Steward, T., & Jamieson, A. J. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02201-5 · Cited by 1 · see citing works
- Authors
- Gonsalves, M., Beck, Q., Fukuda, A., Tirrell, E., Kokdere, F., Kronenberg, E., Iadarola, N., Hagberg, S., Carpenter, L., & Barredo, J.
- Affiliations
- Brown University (US)
- Butler Hospital (US)
- University of Arizona (US)
- University of New Mexico (US)
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 14
- Issue
- 6
- Pages
- 1630-1631
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W3215348977
- Cited by
- 1
- References
- 0
- Citations by year
- 2023: 1
- FWCI
- 0.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain stimulation (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- transcranial ultrasound stimulation, transcranial magnetic stimulation, anxiety disorders, resting-state functional connectivity, motor cortex, neuromodulation, carbamazepine, nimodipine, lorazepam, dextromethorphan, theta burst stimulation, placebo
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