Increased wound pH as an indicator of local wound infection in second degree burns
Abstract
Wound pH affects a number of important factors in wound healing. It is known that the pH of the skin surface of healthy adults and children is 4.2-5.6 and that it decreases with the lapse of epithelialization. We measured the pH of the exudates from second degree burns in 26 cases. Among these, local burn wound infection developed in 6 cases. The causative organisms were Staphylococcus aureus in 2 cases and Staphylococcus epidermidis in 4 cases. The maximum pH value measured was 10.0 and the minimum was 5.0 for all samples. There were no differences in the initial measurements of pH between the non-infected cases and the local-infected cases. In cases of local infection, the pH rose prior to the onset of clinical signs of local burn infection. By consecutive measurement of pH, early detection of local wound infection can be achieved and this is very beneficial in clinical practice. Moreover, measurement is very easy and results are available immediately. In conclusion, consecutive pH measurement of exudates is considered to be a useful indicator in the treatment of second degree burns.
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Persistence of high pH is characteristic of a chronic wound.
“Persistence of high pH is characteristic of a chronic wound [40,41].”
From Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate (2020) · cites this paper as [41]
The pH of the skin immediately increases after damage, being closer to 7.4 and even above 8.
“the pH of the skin immediately increases after damage, being closer to 7.4 [39], and even above 8 [40,41].”
From Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate (2020) · cites this paper as [41]
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Bossak-Ahmad, K., Wiśniewska, M. D., Bal, W., Drew, S. C., & Frączyk, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176190 · Cited by 25 · see citing works
Hassaninejad Farahani, F., Moraffah, F., Samadi, N., Sharifzadeh, M., Motasadizadeh, H., & Vatanara, A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122800 · Cited by 20 · see citing works
- Authors
- Ono, S., Imai, R., Ida, Y., Shibata, D., Komiya, T., & Matsumura, H.
- Affiliations
- Tokyo Medical University (JP)
- Corresponding author
- Matsumura, Hajime
- Venue
- Burns
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 41
- Issue
- 4
- Pages
- 820-824
- ISSN
- 0305-4179 (ISSN-L)
- OpenAlex
- W2095875226
- Cited by
- 252
- References
- 0
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 27 · 2023: 32 · 2022: 36 · 2021: 35 · 2020: 22 · 2019: 21 · 2018: 13 · 2017: 10 · 2016: 3 · 2015: 4
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Burns (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Merck KGaA
- Topics
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Keywords
- wound pH, second-degree burns, Staphylococcus aureus, Staphylococcus epidermidis, early infection detection, burn wound healing, skin pH
- MeSH terms
- Adult, Aged, Burns, Exudates and Transudates, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Prospective Studies, Staphylococcal Infections, Staphylococcus aureus, Staphylococcus epidermidis, Wound Healing, Wound Infection, Cohort Studies, Trauma Severity Indices, Young Adult, Re-Epithelialization
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