Improved infectious burn wound healing by applying lyophilized particles containing probiotics and prebiotics
Abstract
Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers, with the final composition stabilized through freeze-drying. A D-optimal design was used to examine the effects of different polymer concentrations as well as adding prebiotics on the probiotic viability and swelling behavior of the formulations. Scanning electron micrographs revealed stacked particles capable of rapidly absorbing significant amounts of water. These images corresponded to initial swelling percentages of around 2000% for the optimal formulation. The optimized formula had a viability percentage of more than 82%, with the stability studies suggesting that the powders should be stored at refrigerated temperatures. The physical characteristics of the optimized formula were examined to ensure compatibility with its application. According to antimicrobial evaluations, the difference in pathogen inhibition between formulated and fresh probiotics was less than a logarithm. The final formula was tested in vivo and showed improved wound healing indicators. The optimized formula resulted in a higher rate of wound closure and infection clearance. Furthermore, the molecular studies for oxidative stress indicated that the formula could modify wound inflammatory responses. In histological investigations, the probiotic-loaded particles functioned exactly as efficaciously as silver sulfadiazine ointment did.
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Probiotic-loaded particles functioned exactly as efficaciously as silver sulfadiazine ointment in histological investigations.
“Also, histological investigations showed that the probiotic-loaded particles functioned exactly as efficaciously as in the case of silver sulfadiazine ointment.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [100]
Probiotic-loaded microparticles with in situ gelling properties were more effective and improved the management of burn wound infections.
“The researchers declared that the experiments revealed the probiotic-loaded microparticles were more effective and improved the management of burn wound infections.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [100]
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Haghighi, D. M., Javar, H. A., Samadi, N., Abdollahi, M. R., Moraffah, F., Behrouzfar, H., Ghaderzadeh, O., & Vatanara, A. (2026) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2026.2707533
Self-citationWang, A. Y. L., Aviña, A. E., Lin, J. T.-K., Liu, Y., Lin, M. H., & Kao, H. (2026) · Antioxidants · doi:10.3390/antiox15091172
- Authors
- Hassaninejad Farahani, F., Moraffah, F., Samadi, N., Sharifzadeh, M., Motasadizadeh, H., & Vatanara, A.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Pharmaceutical Quality Assurance Research Center (IR)
- Corresponding author
- Vatanara, Alireza
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 636
- Pages
- 122800
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W4323305053
- Cited by
- 20
- References
- 84
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tehran University of Medical Sciences and Health Services (9511266028)
- National Institute for Medical Research Development (987998)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Keywords
- probiotics, prebiotics, Lactobacillus plantarum, freeze-drying, wound healing, burn wounds, antimicrobial activity, probiotic viability, swelling behavior, oxidative stress, wound inflammation, D-optimal design
- MeSH terms
- Burns, Freeze Drying, Humans, Wound Healing, Probiotics, Prebiotics
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