Cited by 23Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerBRCA gene mutations in cancer

No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma

Grützmann, Robert, McFaul, Christopher, Bartsch, Detlef K., Sina-Frey, Mercedes, Rieder, Harald, Koch, Rainer, McCarthy, Emma, Greenhalf, William +3 more·2004·Cancer Letters

Abstract

Familial pancreatic cancer (FPC) (approximately 3% of all cases) has not been linked to defects in any specific gene. Germline inactivation of the gene LKB1/STK11 have been shown to cause Peutz-Jeghers syndrome (PJS) associated with a approximately 100-fold higher risk for the development of pancreatic cancer. We have analysed 39 index patients from European FPC families for mutations of LKB1/STK11 by sequencing of their DNA. No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer.

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Crossref · 10.1016/j.canlet.2004.06.012

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Authors
Grützmann, R., McFaul, C., Bartsch, D. K., Sina-Frey, M., Rieder, H., Koch, R., McCarthy, E., Greenhalf, W., Neoptolemos, J. P., Saeger, H. D., & Pilarsky, C.
Affiliations
  • University Hospital Carl Gustav Carus (DE)
  • University of Liverpool (GB)
  • Philipps University of Marburg (DE)
  • Technische Universität Dresden (DE)
Corresponding author
Pilarsky, Christian
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2004-10
Volume
214
Issue
1
Pages
63-68
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2034414155
Cited by
23
References
40
Citations by year
2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Washington
  • University of Liverpool
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Keywords
STK11/LKB1, germline mutations, familial pancreatic cancer, hereditary pancreatic cancer, Peutz-Jeghers syndrome, genetic susceptibility, mutation detection
MeSH terms
AMP-Activated Protein Kinase Kinases, Adult, Aged, Carcinoma, DNA Mutational Analysis, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Pedigree, Protein Serine-Threonine Kinases, Germ-Line Mutation, Genetic Predisposition to Disease

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