The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen

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Comparative Evaluation of Fecal Fat Excretion Induced by Orlistat and Chitosan

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The permissive role of oxygen‐derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis

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Effects of a high‐fat diet on azoxymethane‐induced aberrant crypt foci and fecal biochemistry and microbial activity in rats

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Orlistat-Associated Adverse Effects and Drug Interactions

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Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?

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Anti-Obesity Drugs: Long-Term Efficacy and Safety: An Updated Review

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Marine Algae as a Potential Source for Anti-Obesity Agents

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gp130 receptor ligands as potential therapeutic targets for obesity

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Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon

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Antiproliferative Effects of Fluoxetine on Colon Cancer Cells and in a Colonic Carcinogen Mouse Model

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Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo

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Obesity and multiple myeloma: Emerging mechanisms and perspectives

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Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats

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The Definition and Prevalence of Obesity and Metabolic Syndrome: Correlative Clinical Evaluation Based on Phenotypes

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Assessment of the mutagenic, recombinagenic and carcinogenic potential of orlistat in somatic cells of Drosophila melanogaster

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Safety assessment of FDA-approved (orlistat and lorcaserin) anti-obesity medications

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Extraction optimization, antidiabetic and antiglycation potentials of aqueous glycerol extract from rice (Oryza sativa L.) bran

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Risk of colorectal cancer after initiation of orlistat: matched cohort study

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Pharmabiotics as an Emerging Medication for Metabolic Syndrome and Its Related Diseases

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In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation

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Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling

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Dietary restriction: could it be considered as speed bump on tumor progression road?

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Hypolipidemic applications of microcrystalline cellulose composite synthesized from different agricultural residues

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Current pharmacotherapeutic concepts for the treatment of obesity in adults

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Inhibitory Effects of Dietary Caraway Essential Oils on 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis is Mediated by Liver Xenobiotic Metabolizing Enzymes

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Diet Induced Obesity Increases the Risk of Colonic Tumorigenesis in Mice

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Glucagon-like peptide 2 in colon carcinogenesis: Possible target for anti-cancer therapy?

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Bioactive Compounds of Underground Valerian Extracts and Their Effect on Inhibiting Metabolic Syndrome-Related Enzymes Activities

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Chemopreventive effects of a Tamarindus indica fruit extract against colon carcinogenesis depends on the dietary cholesterol levels in hamsters

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High-fat diet causes an imbalance in the colonic serotonergic system promoting adipose tissue enlargement and dysplasia in rats

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Pharmacotherapy for Obesity: Past, Present and Future

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Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro

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Berberine is as effective as the anti-obesity drug Orlistat in ameliorating betel-nut induced dyslipidemia and oxidative stress in mice

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Weak Microbial Metabolites: a Treasure Trove for Using Biomimicry to Discover and Optimize Drugs

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Metabolic and bariatric surgery and obesity pharmacotherapy for cancer prevention: current status and future possibilities

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Anti-Obesity Drug Orlistat (Xenical) Is a Novel Antitumor Medication

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Colon preneoplasia after carcinogen exposure is enhanced and colonic serotonergic system is suppressed by food deprivation

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Pineal gland function is required for colon antipreneoplastic effects of physical exercise in rats

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Partial lipectomy reduces dimethylhydrazine-induced carcinogenic initiation in the colon of rats

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Evaluation of the Effect of Orlistatorlistat on Expression of OCT4, Nanog, SOX2, and KLF4 Genes in Colorectal Cancer SW40 Cell Line

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Transcriptomic Analysis of the Protective Effect of Piperine on Orlistat Hepatotoxicity in Obese Male Wistar Rats

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Case Study

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Pharmacotherapy of Childhood Obesity and Pre-diabetes

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The metabolic effect of medicinal plants and synthetic anti-obesity products on human health

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Evaluation of the obesogenic role of betel nut extract in mice and its remediation by berberine and orlistat

Bhattacharjee, K., Nath, M., Sharan, R. N., & Choudhury, Y. (2025) · Toxicon · doi:10.1016/j.toxicon.2025.108636 · Cited by 1

Orlistat: a comprehensive review of a lipase inhibitor from obesity management to emerging oncological applications

Li, L., & Hao, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1944242 · Cited by 1

Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model

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Metabolic syndrome and cancer risk

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Efeitos do exercício físico associado à luz contínua na carcinogênese colônica em ratos

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Study of Colonic Cell Proliferation Induced by Chronic Toxicity of Orlistat and The Possible Protective Effect of Ginseng in Experimental Animals

Hasan, E. I., Zaher, J., Eshak, G. A., & El‐Tahawy, N. F. G. (2011) · Mansoura Journal of Forensic Medicine and Clinical Toxicology · doi:10.21608/mjfmct.2011.55875

Correction: Antiproliferative Effects of Fluoxetine on Colon Cancer Cells and in a Colonic Carcinogen Mouse Model

Kannen, V., Hintzsche, H., Zanette, D. L., Silva, W. A., Garcia, S. B., Waaga-Gasser, A. M., & Stopper, H. (2013) · PLoS ONE · doi:10.1371/annotation/919e5cc0-39bb-4465-babe-d2bdf12e89ff

Gut Microbiome and Obesity: Connecting Link

Mishra, J., Amin, K., Kuang, L., & Kumar, N. (2022) · Springer eBooks · doi:10.1007/978-981-19-3979-2_4

Comparative physiology study of side effect between Xenical and Lipo-6 Supplements which treated obese rabbets

Abdulshaheed, H. G. (2023) · Al-Qadisiyah Journal Of Pure Science · doi:10.29350/2411-3514.1004

Efeitos do metil-jasmonato nanocarreado (A14) na redução da proliferação celular, inibição da angiogênese e indução de apoptose em células de melanoma (B16/F10) implantadas em camundongos

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Progress in Anti-Obesity Drug Development: A Pharmacodynamics Perspective

Ahmad, I., Azmi, S., Albabtain, M. A., Mustafa, M., Kunnathodi, F., Riyasdeen, A., AlWhaiby, B. R., Alharbi, E. M., Arafat, A. A., & Alotaibi, H. F. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101281

Effect of the use of the Orlistat in the cellular proliferation of the colônica mucosa and in the formation of induced aberrant focos of criptas for Dimetilhidrazina in rats.

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Study of Colonic Cell Proliferation Induced by Chronic Toxicity of Orlistat and The Possible Protective Effect of Ginseng in Experimental Animals

Hasan, E. I., Zaher, J., Eshak, G. A., & El‐Tahawy, N. F. G. (2011) · Mansoura Journal of Forensic Medicine and Clinical Toxicology · doi:10.21608/mjfmct.2011.55875

Efeitos do Orlistat na proliferação celular da mucosa colônica e na formação de focos de criptas aberrantes induzidos por Dimetilhidrazina em ratos

Barros, L. T. D. C. (2006) · doi:10.11606/d.17.2006.tde-19012007-145650 · Cited by 1

Effect of Orlistat on Fecal Fat, Fecal Biliary Acids, and Colonic Cell Proliferation in Obese Subjects

Ahnen, D. J., Guerciolini, R., Hauptman, J. B., Blotner, S. D., Woods, C., & Wargovich, M. J. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.009 · Cited by 23

Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling

Jin, B., Kim, H.-J., Sim, S.-A., Lee, M., & An, H. (2021) · Cells · doi:10.3390/cells10082060 · Cited by 37