Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN
Abstract
More and more studies show that signal transducer and activator of transcription 3 (STAT3) is frequently constitutively activated in a wide number of malignancies and named as an attractive molecular target for tumor treatment. Here, we employed STAT3-decoy ODN, which specifically block over-activated STAT3, to treat human hepatocellular carcinoma (HCC) cells, and evaluated the cellular proliferation ability and investigated the molecular mechanisms in vitro. The results demonstrated that the proliferation of HCC cells was suppressed significantly by STAT3-decoy ODN, being associated with the increased apoptosis and cell arrest at G0/G1 to S phase transition. Further investigates showed the expression of STAT3-regulated genes including bcl-x1, cyclin D1 and c-myc, which involved in cell apoptosis and cell cycle progression, were down-regulated significantly both at transcription and translation levels. These data suggested that STAT3 may be potentially used as a molecular target in HCC therapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nucleic acid-based drugs, including decoy oligonucleotides and, perhaps, G-quartet oligonucleotides, inhibit STAT3-mediated gene expression and inhibit growth of different cancer cell lines.
“Nucleic acid–based drugs, including decoy oligonucleotides and, perhaps, G-quartet oligonucleotides, have been identified that inhibit STAT3-mediated gene expression and inhibit growth of different cancer cell lines (Leong et al., 2003; Lewis et al., 2008; Sun et al., 2008; Shen et al., 2009; Zhang et al., 2013b; Liu et al., 2014; Sen et al., 2014).”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Sun et al., 2008
Cites
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743 · see citing works
The role of STATs in transcriptional control and their impact on cellular function
Bromberg, J., & Darnell, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203476 · Cited by 1,201 · see citing works
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
Leong, P. L., Andrews, G. A., Johnson, D. E., Dyer, K. F., Xi, S., Mai, J. C., Robbins, P. D., Gadiparthi, S., Burke, N. A., Watkins, S. F., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0534764100 · Cited by 340 · see citing works
Choudhari, S. R., Khan, M. A., Harris, G., Picker, D., Jacob, G. S., Block, T., & Shailubhai, K. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0561 · Cited by 90 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“These include the following: 1) production of extracellular matrix (ECM) by upregulating collagen type I expression; 2) transcriptional control of MMPs, as well as their cognate inhibitor proteins— tissue inhibitors of MMPs—that also are necessary for the maintenance of ECM (Sun et al., 2008; Wang et al., 2011b; Giann…”
BackgroundInfluentialThe STAT3 pathway as a therapeutic target in head and neck cancer: barriers and innovations
Geiger, J. L., Grandis, J. R., & Bauman, J. E. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2015.11.022 · Cited by 193 · see citing works
Xie, Y., Kole, S., Precht, P., Pazin, M. J., & Bernier, M. (2009) · Endocrinology · doi:10.1210/en.2008-1241 · Cited by 126 · see citing works
- Authors
- Sun, X., Zhang, J., Wang, L., & Tian, Z.
- Affiliations
- Shandong First Medical University (CN)
- Shandong University (CN)
- Corresponding author
- Zhang, Jian
- Tian, Zhigang
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 262
- Issue
- 2
- Pages
- 201-213
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2059069220
- Cited by
- 80
- References
- 4
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 6
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- STAT3, hepatocellular carcinoma, decoy oligonucleotides, cell proliferation, apoptosis, G0/G1 cell cycle arrest, Bcl-xL, cyclin D1, c-Myc, transcriptional regulation, cancer therapy
- MeSH terms
- Cell Cycle, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Oligodeoxyribonucleotides, Transfection, Transcriptional Activation, Apoptosis, Oligodeoxyribonucleotides, Antisense, Cell Line, Tumor, Cell Proliferation, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
