Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics
Abstract
Iron-oxide nanoparticles of small dimensions that have superparamagnetic properties show immense potential to revolutionize the future of cancer theranostics, the combinatorial diagnosis and therapeutic approach towards cancer. Superparamagnetic iron-oxide nanoparticles (SPIONs) have unique magnetic properties, due to which they show excellent tumor-targeting efficiency, and this paves the way for effective personalized cancer treatment. The aim of this review is to focus on the ability of SPIONs to perform multiple roles in the field of cancer biology, such as in diagnosis, monitoring, targeting and therapy. Also, other topics are discussed, including the synthesis of SPIONs, the challenges and recent advances.
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Since nucleic acids have a negative charge due to the presence of the phosphate group, cationic lipids and polymers can be added to iron oxide nanoparticles to carry genetic material.
“Since nucleic acids have a negative charge due to the presence of the phosphate group, cationic lipids and polymers can be added to iron oxide nanoparticles to carry genetic material.96”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [96]
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References 84 · Cited by 236
- Authors
- Santhosh, P. B., & Ulrih, N. P.
- Affiliations
- University of Ljubljana (SI)
- Corresponding author
- Ulrih, Nataša Poklar
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 336
- Issue
- 1
- Pages
- 8-17
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2014293823
- Cited by
- 236
- References
- 84
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 20 · 2022: 11 · 2021: 19 · 2020: 19 · 2019: 20 · 2018: 20 · 2017: 25 · 2016: 17 · 2015: 28 · 2014: 28 · 2013: 5
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, cancer theranostics, MRI contrast agents, tumor targeting, nanoparticle synthesis, cancer diagnosis, cancer therapy, precision oncology
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Magnetic Resonance Imaging, Neoplasms, Surface Properties, Temperature, Drug Delivery Systems, Nanotechnology, Magnetite Nanoparticles
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