The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence
Open accessAbstract
Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular endothelial growth factor, and poly (ADP-ribose) polymerase in a variety of tumor cells. Importantly, synthetic derivative of OA, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), and its C-28 methyl ester (CDDO-Me) and C28 imidazole (CDDO-Im) have demonstrated potent antiangiogenic and antitumor activities in rodent cancer models. These agents are presently under evaluation in phase I studies in cancer patients. This review summarizes the diverse molecular targets of OA and its derivatives and also provides clear evidence on their promising potential in preclinical and clinical situations.
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Cites
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Cited by
Kaur, P., Gupta, R. C., Dey, A., & Kumar Pandey, D. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.12.089 · Cited by 51
Oleanolic acid regulates the Treg/Th17 imbalance in gastric cancer by targeting IL-6 with miR-98-5p
Xu, Q.-F., Peng, H.-P., Lu, X.-R., Hu, Y., Xu, Z.-H., & Xu, J.-K. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155656 · Cited by 36
CDDO-Me Protects Normal Lung and Breast Epithelial Cells but Not Cancer Cells from Radiation
El-Ashmawy, M., Delgado, O., Cardentey, A., Wright, W. E., & Shay, J. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115600 · Cited by 19
Metadata
- Authors
- Shanmugam, M. K., Dai, X., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 346
- Issue
- 2
- Pages
- 206-216
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W1997470573
- Cited by
- 271
- References
- 122
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Shanmugam, M. K., Dai, X., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014). Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence. Cancer Letters. https://doi.org/10.1016/j.canlet.2014.01.016
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