The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Mechanisms regulating glioma invasion
Open accessAbstract
Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy in adults. Despite the advances made in surgical techniques, radiotherapy and chemotherapy, the median survival for GBM patients has remained at a mere 14 months. GBM poses several unique challenges to currently available treatments for the disease. For example, GBM cells have the propensity to aggressively infiltrate/invade into the normal brain tissues and along the vascular tracks, which prevents complete resection of all malignant cells and limits the effect of localized radiotherapy while sparing normal tissue. Although anti-angiogenic treatment exerts anti-edematic effect in GBM, unfortunately, tumors progress with acquired increased invasiveness. Therefore, it is an important task to gain a deeper understanding of the intrinsic and post-treatment invasive phenotypes of GBM in hopes that the gained knowledge would lead to novel GBM treatments that are more effective and less toxic. This review will give an overview of some of the signaling pathways that have been shown to positively and negatively regulate GBM invasion, including, the PI3K/Akt, Wnt, sonic hedgehog-GLI1, and microRNAs. The review will also discuss several approaches to cancer therapies potentially altering GBM invasiveness.
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Identification of diverse astrocyte populations and their malignant analogs
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Verdugo, E., Puerto, I., & Medina, M. Á. (2022) · Cancer Communications · doi:10.1002/cac2.12361 · Cited by 253
Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy
Yi, Y., Hsieh, I.-Y., Huang, X., Li, J., & Zhao, W. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00477 · Cited by 105
Mwale, P. F., Hsieh, C.-T., Yen, T.-L., Jan, J.-S., Taliyan, R., Yang, C.-H., & Yang, W.-B. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00801-8 · Cited by 47
Yuan, Y., Xiang, W., Yanhui, L., Ruofei, L., Yunhe, M., Jiewen, L., & Qing, M. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.08.005 · Cited by 17
Metadata
- Authors
- Paw, I., Carpenter, R. C., Watabe, K., Debinski, W., & Lo, H.-W.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 362
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2034437737
- Cited by
- 306
- References
- 82
- FWCI
- 20.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Paw, I., Carpenter, R. C., Watabe, K., Debinski, W., & Lo, H.-W. (2015). Mechanisms regulating glioma invasion. Cancer Letters. https://doi.org/10.1016/j.canlet.2015.03.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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