The DOI matches its Crossref record.
Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy
Abstract
Objective Approximately 80% of glioma patients will experience at least one seizure activity during the course of the disease, and because the etiology of glioma-related seizure is most likely multifactorial and complex, it remains poorly understood. MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators. MicroRNA-128 was found to be decreased in glioblastoma, and knockout of the microRNA-128a gene could induce epilepsy in mice. Based on the Chinese Glioma Genome Atlas and previous study, we hypothesized that dysregulation of miR-128 expression may play a role in the pathogenesis of TAE in low-grade glioma. Methods Fifty-three low-grade glioma samples were analyzed for the expression levels of miR-128 using qRT-PCR, and candidate targets of miR-128 (Cacnge2, GRIK3, and GRIN2D) were detected by the 3'-UTR luciferase reporter assay. Four other miRs (miR-9, miR-192a, miR-92a, and miR-451) that showed dysregulation of glioblastoma in the CGGA data were also analyzed. Results The microRNA-128 expression levels were down-regulated in low-grade glioma tissue (t-test; p=0.009). Dysregulation of miR-128 expression in low-grade glioma is associated with glioma-associated epilepsy (p=0.006). No statistical significance of miR-9, miR-192a, miR-92a, and miR-451 was found to be associated with LGG. Conclusion Our results here, together with other recent lines of evidence, indicate that miR-128 is an extremely attractive target for therapy in glioma patients…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Notably, low levels of miR-128-3p in low-grade gliomas have also been implicated in glioma-associated seizures.52”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [52]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 23
- Claus, 2015, Survival and low-grade glioma: the emergence of genetic information, Neurosurg. Focus, 38, E6, 10.3171/2014.10.FOCUS12367 · DOI
- de Groot, 2012, Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy, Epilepsia, 53, 58, 10.1111/j.1528-1167.2011.03306.x · DOI
- Huang, 2015, miR-340 suppresses glioblastoma multiforme, Oncotarget, 16
- Huyghe, 2011, Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking, J. Neurosci., 31, 11645, 10.1523/JNEUROSCI.2206-11.2011 · DOI
- Jin, 2014, miRNA-128 suppresses prostate cancer by inhibiting BMI-1 to inhibit tumor-initiating cells, Cancer Res., 1, 4183, 10.1158/0008-5472.CAN-14-0404 · DOI
- Kilic, 2010, Are GRIK3 (T928G) gene variants in schizophrenia patients different from those in their first-degree relatives?, Psychiatry Res., 175, 43, 10.1016/j.psychres.2008.10.001 · DOI
- Lia, 2013, miR-128 and its target genes in tumorigenesis and metastasis, Exp. Cell Res., 319, 3059, 10.1016/j.yexcr.2013.07.031 · DOI
- Liubinas, 2014, Tumour associated epilepsy and glutamate excitotoxicity in patients with gliomas, J. Clin. Neurosci., 21, 899, 10.1016/j.jocn.2014.02.012 · DOI
- Paw, 2015, Mechanisms regulating glioma invasion, Cancer Lett., 18, 00195
- Selvakumar, 2014, AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin, Neuropharmacology, 77, 28, 10.1016/j.neuropharm.2013.08.036 · DOI
- Sun, 2014, A glioma classification scheme based on coexpression modules of EGFR and PDGFRA, Proc. Natl. Acad. Sci. U. S. A., 111, 3538, 10.1073/pnas.1313814111 · DOI
- Tan, 2013, MicroRNA-128 governs neuronal excitability and motor behavior in mice, Science, 6, 1254, 10.1126/science.1244193 · DOI · Paper page
- Wang, 2015, Localizing seizure-susceptible brain regions associated with low-grade gliomas using voxel-based lesion-symptom mapping, Neuro Oncol., 17, 282, 10.1093/neuonc/nou130 · DOI
- Waqar, 2015, Prognostic factors in lobar WHO grade II astrocytomas, World Neurosurg., 15, 00204
- Yang, 2014, Correlation of preoperative seizures with clinicopathological factors and prognosis in anaplastic gliomas: a report of 198 patients from China, Seizure, 23, 844, 10.1016/j.seizure.2014.07.003 · DOI
- Yao, 2014, Glutamate/glutamine metabolism coupling between astrocytes and glioma cells: neuroprotection and inhibition of glioma growth, Biochem. Biophys. Res. Commun., 18, 295, 10.1016/j.bbrc.2014.05.120 · DOI
- You, 2012, Clinical and molecular genetic factors affecting postoperative seizure control of 183 Chinese adult patients with low-grade gliomas, Eur. J. Neurol., 19, 298, 10.1111/j.1468-1331.2011.03509.x · DOI
- Yuan, 2013, Ki-67 overexpression in WHO grade II gliomas is associated with poor postoperative seizure control, Seizure, 22, 877, 10.1016/j.seizure.2013.08.004 · DOI
- Yuan, 2014, Survival analysis for valproic acid use in adult glioblastoma multiforme: a meta-analysis of individual patient data and a systematic review, Seizure, 23, 830, 10.1016/j.seizure.2014.06.015 · DOI
- Yuana, 2014, P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: a meta-analysis, Seizure, 616, 10.1016/j.seizure.2014.04.016 · DOI
- Yuen, 2012, Glutamate is associated with a higher risk of seizures in patients with gliomas, Neurology, 28, 883, 10.1212/WNL.0b013e318266fa89 · DOI
- Zhang, 2014, Identification of miRNA-mediated core gene module for glioma patient prediction by integrating high-throughput miRNA, mRNA expression and pathway structure, PLoS One, 8, e96908, 10.1371/journal.pone.0096908 · DOI
- Zhang, 2014, GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease, J. Neurochem., 129, 581, 10.1111/jnc.12658 · DOI
Cited by
Sorted by citations
MiR-128-3p – a gray eminence of the human central nervous system
Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J. (2024) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2024.102141 · Cited by 15
Metadata
- Authors
- Yuan, Y., Xiang, W., Yanhui, L., Ruofei, L., Yunhe, M., Jiewen, L., & Qing, M.
- ORCID
- Qing, Mao
- Venue
- Epilepsy Research
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 127
- Pages
- 6-11
- ISSN
- 0920-1211
- Cited by
- 17
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy. https://app.cochat.ai/papers/10.1016/j.eplepsyres.2016.08.005
- The paper
- Yuan, Y., Xiang, W., Yanhui, L., Ruofei, L., Yunhe, M., Jiewen, L., & Qing, M. (2016). Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy. Epilepsy Research. https://doi.org/10.1016/j.eplepsyres.2016.08.005
