The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.
Chitin oligosaccharides inhibit oxidative stress in live cells
Abstract
The aim of this research is to identify the cellular antioxidant effects of chitin oligosaccharides (NA-COS; M(w) 229.21-593.12 Da) produced by acidic hydrolysis of crab chitin. The inhibitory effect of NA-COS on myeloperoxidase (MPO) activity in human myeloid cells (HL-60) and oxidation of DNA and protein in mouse macrophages (Raw 264.7) were identified. Furthermore, their direct radical scavenging effect by 2',7'-dichlorofluorescein (DCF) intensity and intracellular glutathione (GSH) level were significantly increased in a time dependent manner, respectively. These results suggest that NA-COS act as a potent antioxidant in live cells.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“ROS (reactive oxygen species) and NOS (nitrogen reactive species) attack biomolecules like DNA, proteins, and membrane lipids, leading to many severe diseases including cancer, coronary arteries disease, obesity, diabetes, ischemic stroke, and Alzheimer disease [216].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [216]
Citations
Cites
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
Hansen, M., Nielsen, S. E., & Berg, K. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90397-9 · Cited by 3,488
Controlling cell adhesion and degradation of chitosan films by N-acetylation
Freier, T., Koh, H. S., Kazazian, K., & Shoichet, M. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.033 · Cited by 587
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia
Calabrese, V., Lodi, R., Tonon, C., D’Agata, V., Sapienza, M. A., Scapagnini, G., Mangiameli, A., Pennisi, G., Stella, A. M. G., & Butterfield, D. A. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.012 · Cited by 411
Jeon, Y., & Kim, S.-K. (2000) · Carbohydrate Polymers · doi:10.1016/s0144-8617(99)00084-3 · Cited by 309
Self-citationVandevelde, K., & Kiekens, P. (2004) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2004.08.004 · Cited by 309
Free radical scavenging properties of hetero-chitooligosaccharides using an ESR spectroscopy.
Je, J.-Y., Park, P., & Kim, S.-K. (2004) · Food and Chemical Toxicology · doi:10.1016/j.fct.2003.10.001 · Cited by 215
Self-citationMilne, L., Nicotera, P., Orrenius, S., & Burkitt, M. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1327 · Cited by 188
Depolymerized products of chitosan as potent inhibitors of tumor-induced angiogenesis
Prashanth, K. V. H., & Tharanathan, R. N. (2004) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.11.009 · Cited by 179
Research works printed but not linked: 1
- Vongchan, 2003, Anticoagulant activities of the chitosan polysulfate synthesized from marine crab shell by semi-heterogeneous conditions, Science Asia, 29, 115, 10.2306/scienceasia1513-1874.2003.29.115 · DOI
Cited by
Sorted by citations
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082
Biological activities of chitosan and chitooligosaccharides
Xia, W., Liu, P., Zhang, J., & Chen, J. (2010) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2010.03.003 · Cited by 838
Chitosan oligosaccharide (COS): An overview
Naveed, M., Phil, L., Sohail, M., Hasnat, M., Baig, M. M. F. A., Ihsan, A. U., Shumzaid, M., Kakar, M. U., Khan, T. M., Akabar, M., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.01.192 · Cited by 524
Chitooligosaccharides and their biological activities: A comprehensive review
Liaqat, F., & Eltem, R. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.12.067 · Cited by 503
Antioxidant Effects of Chitin, Chitosan, and Their Derivatives
Ngo, D.-H., & Kim, S. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800268-1.00002-0 · Cited by 393
Self-citation
Metadata
- Authors
- Ngo, D.-N., Kim, M.-M., & Kim, S.-K.
- Affiliations
- Pukyong National University (KR)
- Dong-Eui University (KR)
- Corresponding author
- Kim, Moon-Moo
- Kim, Se-Kwon
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 74
- Issue
- 2
- Pages
- 228-234
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2037747961
- Cited by
- 163
- References
- 29
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 15
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- chitin oligosaccharides, antioxidant activity, oxidative stress, myeloperoxidase inhibition, DNA oxidation, protein oxidation, free radical scavenging, glutathione, acid hydrolysis, HL-60 cells, RAW 264.7 macrophages
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
