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Anticoagulant activity, paw edema and pleurisy induced carrageenan: Action of major types of commercial carrageenans
Open accessAbstract
Considering the use of commercials carrageenans as a model for inflammation, the aim this work is a comparative study these compounds in the pro-inflammatory action by ear edema and pleurisy and to analyze their anticoagulant activity. Paw edema was induced by injecting kappa, iota and lambda carrageenans in saline solution into the hind paw of male Wistar rats (p < 0.05). The three types of carrageenans showed different volume in pleural exudates, characterized by fluid accumulation, a large number of neutrophils and raised NO production (p < 0.001). The activated partial thromboplastin time (aPTT) for kappa and iota carrageenans (100 μg) was 240 s and 132 s, respectively. Lambda carrageenan was the most potent anticoagulant at 240 s (20 μg). These carragenans demonstrated no anticoagulant action using the PT test in vitro. Histological analysis in paw edema demonstrated that iota and lambda carrageenans showed major cellular infiltration in relation to kappa. Thus, quantitative evaluation of inflammation demonstrated that iota and lambda carrageenans have higher inflammatory potential than do kappa carrageenans.
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“The anticoagulant and antithrombotic activities in vitro of macroalgal polysaccharides have been predominantly related to the structure and the dregree of sulphation of the polysaccharide”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Silva et al., 2010
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Loffredo, M. K., Ham, H. O., Varghese, M., Haller, C. A., Chaikof, E. L., & Grinstaff, M. W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.09.737190
Metadata
- Authors
- Silva, F. R. F., Dore, C. M. P. G., Marques, C. T., Nascimento, M. S., Benevides, N. M. B., Rocha, H. A. O., Chavante, S. F., & Leite, E. L.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Corresponding author
- Leite, E.L.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 79
- Issue
- 1
- Pages
- 26-33
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W1990331189
- Cited by
- 212
- References
- 29
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 12 · 2023: 22 · 2022: 19 · 2021: 16 · 2020: 26 · 2019: 12 · 2018: 14 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 7 · 2012: 12
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- carrageenan, kappa-carrageenan, iota-carrageenan, lambda-carrageenan, anticoagulant activity, paw edema, pleurisy, pleural exudate, neutrophil infiltration, nitric oxide production, activated partial thromboplastin time, pro-inflammatory activity, inflammation model
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