Cited by 33Hydrogels: synthesis, properties, applicationsPolysaccharides Composition and ApplicationsCollagen: Extraction and Characterization

Method for preparation of planar alginate hydrogels by external gelling using an aerosol of gelling solution

Papajová, Eva, Bujdoš, Marek, Chorvát, Dušan, Stach, Marek, Lacík, Igor·2012·Carbohydrate Polymers

Abstract

Preparation of planar alginate hydrogels by external gelling requires slow rate of exposure of alginate solution to gelling ions to control gelling process and hydrogel properties. We tackled this issue by exposing solution of sodium alginate to solution of CaCl2 applied as aerosol at exposure rate of 7.5 mg cm(-2) s(-1). Gelling conditions varied with respect to concentrations of sodium alginate (1-3 wt.%) and CaCl2 (0.5-4 wt.%), exposure time (2.5-40 min), the 2nd gelling step in the presence of barium ions, and the storage step. Dimensional stability and Young's modulus values were the principal determined quantities to examine the correlation between hydrogel properties and gelling protocol. The content of calcium ions in hydrogel after gelling by CaCl2 aerosol reveals that the maximum binding capacity of calcium ions by alginate chains was reached. Obtained data suggest that an unusual gelling mechanism related to exposure of sodium alginate to aerosol of gelling solution does not need to be considered since the properties of planar alginate hydrogels follow the trends relevant to general knowledge about alginate hydrogels.

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Crossref · 10.1016/j.carbpol.2012.05.067

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  • Size and shape, rather than stiffness, play a critical role in biocompatibility, based on evaluation of materials with stiffness ranging from soft alginate hydrogels (<100 kPa) to hard stainless steel (100s of GPa).

    “Notably, our evaluation of a spectrum of materials with a range of mechanical stiffness properties varying from soft (Alginate hydrogels, < 100 kPa)34 to hard (Stainless steel, 100s of GPa)35 demonstrates that size and shape rather than stiffness plays a critical role in biocompatibility.”

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Authors
Papajová, E., Bujdoš, M., Chorvát, D., Stach, M., & Lacík, I.
Affiliations
  • Polymer Institute of the Slovak Academy of Sciences (SK)
  • Comenius University Bratislava (SK)
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2012-09
Volume
90
Issue
1
Pages
472-482
ISSN
0144-8617 (ISSN-L)
OpenAlex
W2071860020
Cited by
33
References
51
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Locations
  • Carbohydrate Polymers (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agentúra na Podporu Výskumu a Vývoja (APVV-0302-10, APVV-0486-10)
  • European Regional Development Fund
  • Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (2/0163/12)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Keywords
alginate hydrogel, sodium alginate, barium ions, dimensional stability, Young's modulus, calcium binding capacity, gelling mechanism, hydrogel synthesis

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