Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities
Abstract
In the present work, optimization of microwave-assisted extraction of polysaccharides from Sargassum thunbergii was investigated. The physicochemical properties, structural characteristics, and in vitro antioxidant and hypoglycemic activities were determined. The optimal extraction conditions with a yield of 2.84±0.09% for extraction of polysaccharides (STP-1) were extraction time 23min, microwave power 547W, extraction temperature 80°C, and the ratio of raw material to water 1:27g/mL. STP-1 contained 32.7% of total carbohydrate, 1.86% of protein, and 15.2% of sulfates. STP-1 had a major molecular weight of 190.4kDa, and comprised of arabinose, galactose, glucose, xylose, mannose, galacturonic acid, and glucuronic acid with molar percentages of 1.94, 30.7, 4.54, 23.2, 17.6, 8.11, and 13.9%, respectively. In addition, STP-1 showed strong antioxidant and α-glucosidase inhibitory activities, and could improve the glucose uptake in insulin-resistant HepG2 cells, suggesting that STP-1 can be exploited as a promising natural antioxidant and hypoglycemic agent.
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Similar behavior to the effect of time occurred during the increase of microwave power and the extraction temperature.
“Similar behavior occurred during the increase of microwave power and the extraction temperature.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [75]
As time increased, the yield also increased, but excessive time can have the opposite effect and can lead to degradation of polysaccharides.
“As time increased, the yield also increased, but excessive time can have the opposite effect and it can lead to degradation of polysaccharides.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [75]
Extracts with polysaccharides exhibited good inhibitory effects against α-glucosidase, and they could be potential hypoglycemic agents applied in food or pharmaceutical industry.
“Ren et al. [75] showed that the extracts with polysaccharides exhibited good inhibitory effects against α-glucosidase, and they could be potential hypoglycemic agent applied in food or pharmaceutical industry.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [75]
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References 33 · Cited by 217
- Authors
- Ren, B., Chen, C., Li, C., Fu, X., You, L., & Liu, R. H.
- Affiliations
- South China University of Technology (CN)
- Cornell University (US)
- Corresponding author
- Li, Chao
- Fu, Xiong
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 173
- Pages
- 192-201
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2620744488
- Cited by
- 217
- References
- 33
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 25 · 2023: 31 · 2022: 28 · 2021: 24 · 2020: 17 · 2019: 23 · 2018: 21 · 2017: 4
- FWCI
- 20.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (2016M602474)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- Sargassum thunbergii, seaweed polysaccharides, microwave-assisted extraction, extraction optimization, antioxidant activity, hypoglycemic activity, α-glucosidase inhibition, glucose uptake, insulin resistance, HepG2 cells, polysaccharide structural characterization, sulfated polysaccharides
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