Chitosan based bioadhesives for biomedical applications: A review
Abstract
Due to the promising properties of chitosan for biomedical engineering applications like biodegradability, biocompatibility, and non-toxicity, it is one of the most interesting biopolymers in this field. Therefore, Chitosan and its derivatives have attracted great attention in vast variety of biomedical applications. In the current paper, different types of chitosan-based bioadhesives including passive and active and their different types of external stimuli response structure such as thermo, pH and Light responsive systems are discussed. Different bioadhesives mechanisms with chitosan as an adhesive agent or main polymer component and some examples were also presented. Chitosan based bioadhesives and their potential biomedical applications in drug delivery systems, suture less surgery, wound dressing and hemostatic are also discussed. The results confirmed wound healing, hemostatic and bioadhesion capabilities of the chitosan bioadhesives and its great potential for biomedical applications.
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γ-Chitosan offers a sustained anti-adhesion effect while allowing controlled degradation to support wound healing and tissue regeneration.
“It also offers a sustained anti-adhesion effect while allowing controlled degradation to support wound healing and tissue regeneration [165].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [165]
Cites
Huang, W., Cheng, S., Wang, X., Zhang, Y., Chen, L., & Zhang, L. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009189 · Cited by 272 · see citing works
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Chitosan Based Materials in Cosmetic Applications: A Review
Kulka, K., & Sionkowska, A. (2023) · Molecules · doi:10.3390/molecules28041817 · Cited by 157 · see citing works
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Hamedi, H., Moradi, S., Hudson, S. M., Tonelli, A. E., & King, M. W.
- Affiliations
- North Carolina State University (US)
- Arak University (IR)
- Corresponding author
- Tonelli, Alan E.
- King, Martin W.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 282
- Pages
- 119100
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4205210525
- Cited by
- 281
- References
- 1
- Citations by year
- 2026: 33 · 2025: 79 · 2024: 77 · 2023: 58 · 2022: 33 · 2021: 1
- FWCI
- 14.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- chitosan, bioadhesives, chitosan derivatives, stimuli-responsive materials, temperature-responsive, pH-responsive, light-responsive, biodegradability, biocompatibility, drug delivery systems, sutureless surgery, wound dressings, hemostasis, wound healing
- MeSH terms
- Animals, Biocompatible Materials, Humans, Tissue Adhesives, Chitosan
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