Cited by 272Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

Noncompressible Hemostasis and Bone Regeneration Induced by an Absorbable Bioadhesive Self‐Healing Hydrogel

Huang, Weijuan, Cheng, Shi, Wang, Xiaolan, Zhang, Yu, Chen, Lingyun, Zhang, Lina·2021·Advanced Functional Materials

Abstract

Bone bleeding and bone defects arising from trauma or bone tumor resection pose a great threat to patients and they are challenging problems to orthopedic surgeons. Traditional hemostatic materials are not suitable for bone fractures where compression cannot be applied, neither are they effective during surgeries where large amounts of body fluids prevent them from adhering to the large and irregular bone wound sites. This research introduces a catechol‐conjugated chitosan (CHI‐C) multi‐functional hydrogel with adhesion, self‐healing, cytocompatibility, hemocompatibility, and blood cell coagulation capacity. The hydrogel can be injected into internal and irregular bleeding sites and bone defective areas, and then rapidly self‐heals (within 2 min) to an integrated hydrogel that fully fills the defective sites and strongly sticks to bleeding areas in the presence of body fluids during surgery. In vivo experiments using a rabbit ilium bone defect model demonstrate quick hemostasis after the hydrogel is applied and the blood loss is only ¼ compared to the untreated injuries. In addition, the bone regeneration is not interfered by the hydrogel and the bone defect is no longer visible with disappearance of the hydrogel after 4 weeks. This multi‐functional hydrogel is potentially valuable for clinical applications towards tissue adhesion, hemostasis, and bone regeneration.

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Crossref · 10.1002/adfm.202009189

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Authors
Huang, W., Cheng, S., Wang, X., Zhang, Y., Chen, L., & Zhang, L.
Affiliations
  • South China Agricultural University (CN)
  • Guangdong Academy of Medical Sciences (CN)
  • University of Alberta (CA)
  • Wuhan University (CN)
Corresponding author
  • Zhang, Yu
  • Chen, Lingyun
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2021-02-28
Volume
31
Issue
22
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
OpenAlex
W3133980713
Cited by
272
References
51
Citations by year
2026: 26 · 2025: 57 · 2024: 72 · 2023: 50 · 2022: 58 · 2021: 9
FWCI
30.88
Type
journal article
Language
en
Open access
closed
Locations
Advanced Functional Materials (publishedVersion)
Funders
  • Natural Sciences and Engineering Research Council of Canada
  • National Natural Science Foundation of China (31700880, 31771038)
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
hemostasis, bone regeneration, self-healing hydrogels, bioadhesive hydrogel, bone defects, injectable hydrogel, hemocompatibility, tissue adhesion, bone tumor resection

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