Noncompressible Hemostasis and Bone Regeneration Induced by an Absorbable Bioadhesive Self‐Healing Hydrogel
Abstract
Bone bleeding and bone defects arising from trauma or bone tumor resection pose a great threat to patients and they are challenging problems to orthopedic surgeons. Traditional hemostatic materials are not suitable for bone fractures where compression cannot be applied, neither are they effective during surgeries where large amounts of body fluids prevent them from adhering to the large and irregular bone wound sites. This research introduces a catechol‐conjugated chitosan (CHI‐C) multi‐functional hydrogel with adhesion, self‐healing, cytocompatibility, hemocompatibility, and blood cell coagulation capacity. The hydrogel can be injected into internal and irregular bleeding sites and bone defective areas, and then rapidly self‐heals (within 2 min) to an integrated hydrogel that fully fills the defective sites and strongly sticks to bleeding areas in the presence of body fluids during surgery. In vivo experiments using a rabbit ilium bone defect model demonstrate quick hemostasis after the hydrogel is applied and the blood loss is only ¼ compared to the untreated injuries. In addition, the bone regeneration is not interfered by the hydrogel and the bone defect is no longer visible with disappearance of the hydrogel after 4 weeks. This multi‐functional hydrogel is potentially valuable for clinical applications towards tissue adhesion, hemostasis, and bone regeneration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hydrogels can be functionalized to achieve specific properties and structures.
“hydrogels can be functionalized to achieve specific properties and structures”
From Functionalized Hydrogel-Based Wearable Gas and Humidity Sensors. (2023) · cites this paper as [64]
Cites
Structural absorption by barbule microstructures of super black bird of paradise feathers
McCoy, D. E., Feo, T., Harvey, T. A., & Prum, R. O. (2018) · Nature Communications · doi:10.1038/s41467-017-02088-w · Cited by 7,424 · see citing works
Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review
Suh, J.-K., & Matthew, H. W. T. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00126-5 · Cited by 2,004 · see citing works
Qu, J., Zhao, X., Liang, Y., Zhang, T., Ma, P. X., & Guo, B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.044 · Cited by 1,815 · see citing works
Self-healing polymeric materials: A review of recent developments
Wu, D. Y., Meure, S., & Solomon, D. H. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.02.001 · Cited by 1,392 · see citing works
Zhao, X., Guo, B., Wu, H., Liang, Y., & Ma, P. X. (2018) · Nature Communications · doi:10.1038/s41467-018-04998-9 · Cited by 1,169 · see citing works
Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering
Wang, H., & Heilshorn, S. C. (2015) · Advanced Materials · doi:10.1002/adma.201501558 · Cited by 722 · see citing works
Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
Ryu, J. H., Lee, Y., Kong, W. H., Kim, T. G., Park, T. G., & Lee, H. (2011) · Biomacromolecules · doi:10.1021/bm200464x · Cited by 677 · see citing works
Zhang, Y., Tao, L., Shu-xi, L., & Wei, Y. (2011) · Biomacromolecules · doi:10.1021/bm200423f · Cited by 671 · see citing works
Self-citationHe, J., Shi, M., Liang, Y., & Guo, B. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124888 · Cited by 623 · see citing works
Huang, W., Wang, Y., Huang, Z., Wang, X., Chen, L., Zhang, Y. X., & Zhang, L. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b14526 · Cited by 508 · see citing works
Self-citationSelf-Healing Mussel-Inspired Multi-pH-Responsive Hydrogels
Krogsgaard, M., Behrens, M. A., Pedersen, J. S., & Birkedal, H. (2013) · Biomacromolecules · doi:10.1021/bm301844u · Cited by 439 · see citing works
Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
Chen, G., Yu, Y., Wu, X., Wang, G., Ren, J., & Zhao, Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801386 · Cited by 435 · see citing works
Shin, J., Lee, J. S., Lee, C., Park, H., Yang, K., Jin, Y., Ryu, J. H., Hong, K. S., Moon, S., Chung, H., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500006 · Cited by 432 · see citing works
Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review
Ryu, J. H., Hong, S., & Lee, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.043 · Cited by 428 · see citing works
An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats
Hasani‐Sadrabadi, M. M., Sarrión, P., Pouraghaei, S., Chau, Y., Ansari, S., Li, S., Aghaloo, T. L., & Moshaverinia, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6853 · Cited by 337 · see citing works
Yang, X., Bakaic, E., Hoare, T. R., & Cranston, E. D. (2013) · Biomacromolecules · doi:10.1021/bm401364z · Cited by 301 · see citing works
Jung, H., Kim, M. K., Lee, J. Y., Choi, S. W., & Kim, J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004407 · Cited by 295 · see citing works
Chitosan-catechol: A polymer with long-lasting mucoadhesive properties
Kim, K., Kim, K., Ryu, J. H., & Lee, H. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.010 · Cited by 283 · see citing works
Application of rod-shaped cellulose nanocrystals in polyacrylamide hydrogels
Zhou, C., Wu, Q., Yue, Y., & Zhang, Q. (2010) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2010.09.035 · Cited by 282 · see citing works
Yang, B., Zhang, Y., Zhang, X., Tao, L., Li, S., & Wei, Y. (2012) · Polymer Chemistry · doi:10.1039/c2py20627g · Cited by 281 · see citing works
Self-citationLee, C., Shin, J., Lee, J. S., Byun, E., Ryu, J. H., Um, S. H., Kim, D., Lee, H., & Cho, S. (2013) · Biomacromolecules · doi:10.1021/bm400352d · Cited by 278 · see citing works
Complete prevention of blood loss with self-sealing haemostatic needles
Shin, M., Park, S.-G., Oh, B., Kim, K., Jo, S., Lee, M. S., Oh, S. S., Hong, S.-H., Shin, E., Kim, K., et al. (2016) · Nature Materials · doi:10.1038/nmat4758 · Cited by 270 · see citing works
Li, S., Wang, L., Zheng, W., Yang, G., & Jiang, X. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002370 · Cited by 267 · see citing works
Injectable and Self-Healing Carbohydrate-Based Hydrogel for Cell Encapsulation
Lü, S., Gao, C., Xu, X., Bai, X. F., Duan, H., Gao, N., Feng, C., Xiong, Y., & Liu, M. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b03143 · Cited by 249 · see citing works
Solubilization of dialdehyde cellulose by hot water
Kim, U., Wada, M., & Kuga, S. (2004) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2003.10.013 · Cited by 238 · see citing works
Mussel-inspired hyperbranched poly(amino ester) polymer as strong wet tissue adhesive
Zhang, H., Bré, L. P., Zhao, T., Zheng, Y., Newland, B., & Wang, W. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.017 · Cited by 233 · see citing works
Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin
Grainger, D. J., Wakefield, L. M., Bethell, H., Farndale, R. W., & Metcalfe, J. C. (1995) · Nature Medicine · doi:10.1038/nm0995-932 · Cited by 225 · see citing works
Ferreira, F. V., Otoni, C. G., France, K. J. D., Barud, H. D. S., Lona, L. M. F., Cranston, E. D., & Rojas, O. J. (2020) · Materials Today · doi:10.1016/j.mattod.2020.03.003 · Cited by 223 · see citing works
Malette, W. G., Quigley, H. J., Gaines, R. D., Johnson, N. D., & Rainer, W. G. (1983) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)60649-2 · Cited by 212 · see citing works
Mussel-inspired hydrogels for biomedical and environmental applications
Li, L., Smitthipong, W., & Zeng, H. (2014) · Polymer Chemistry · doi:10.1039/c4py01415d · Cited by 208 · see citing works
Kim, K., Ryu, J. H., Lee, D. Y., & Lee, H. (2013) · Biomaterials Science · doi:10.1039/c3bm00004d · Cited by 200 · see citing works
In vitro hemocompatibility testing of UV-modified hyaluronan hydrogels
Amarnath, L. P., Srinivas, A., & Ramamurthi, A. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.08.008 · Cited by 129 · see citing works
Osseous regeneration in the presence of four common hemostatic agents
Finn, M. D., Schow, S. R., & Schneiderman, E. D. (1992) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/0278-2391(92)90443-4 · Cited by 128 · see citing works
A novel DOPA-albumin based tissue adhesive for internal medical applications
Zhu, W., Peck, Y., Iqbal, J., & Wang, D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.016 · Cited by 100 · see citing works
A novel synthetic tissue‐adhesive hydrogel using a crosslinkable polymeric micelle
Murakami, Y., Yokoyama, M., Okano, T., Nishida, H., Tomizawa, Y., Endo, M., & Kurosawa, H. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30911 · Cited by 85 · see citing works
Lu, D., Wang, H., Li, T., Li, Y., Dou, F., Shaobo, S., Guo, H., Liao, S., Yang, Z., Wei, Q., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16575 · Cited by 81 · see citing works
Preparation and blood compatibility of polysiloxane/liquid-crystal composite membranes
Li, L., Tu, M., Mou, S., & Zhou, C. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00222-2 · Cited by 72 · see citing works
The clotting system – a major player in wound healing
Monroe, D. M., & Hoffman, M. (2012) · Haemophilia · doi:10.1111/j.1365-2516.2012.02889.x · Cited by 69 · see citing works
Liu, C., Wu, J., Gan, D., Li, Z., Shen, J., Tang, P., Luo, S., Li, P., Lu, X., & Zheng, W. (2020) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.34524 · Cited by 57 · see citing works
Synergy in thrombin-graphene sponge for improved hemostatic efficacy and facile utilization
Li, G., Quan, K., Xu, C., Deng, B., & Wang, X. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.10.021 · Cited by 52 · see citing works
Self-citationSelf-Assembling Peptide Nanofibrous Hydrogel on Immediate Hemostasis and Accelerative Osteosis
Wu, M. C., Ye, Z., Zhu, H., & Zhao, X. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00493 · Cited by 47 · see citing works
Li, W., Feng, R., Wang, R., Li, D., Jiang, W., Liu, H., Guo, Z., Serpe, M. J., & Hu, L. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01160e · Cited by 46 · see citing works
Salvianolic acid B modulates hemostasis properties of human umbilical vein endothelial cells
Shi, C., Huang, H., Wu, H., Kuo, C., Chang, B.-I., Shiao, M., & Shi, G.-Y. (2006) · Thrombosis Research · doi:10.1016/j.thromres.2006.06.008 · Cited by 44 · see citing works
Decreased blood loss reduces postoperative complications in resection for hepatocellular carcinoma
Aramaki, O., Takayama, T., Higaki, T., Nakayama, H., Ohkubo, T., Midorikawa, Y., Moriguchi, M., & Matsuyama, Y. (2014) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.101 · Cited by 44 · see citing works
Bowman, P. D., Wang, X., Meledeo, M. A., Dubick, M. A., & Kheirabadi, B. S. (2011) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3182033579 · Cited by 41 · see citing works
Self-citationThe use of local agents: bone wax, gelatin, collagen, oxidized cellulose
Schönauer, C., Tessitore, E., Moraci, A., Barbagallo, G. M. V., & Albanese, V. (2005) · Springer eBooks · doi:10.1007/3-540-27394-8_15 · Cited by 34 · see citing works
Does Bone Wax Induce a Chronic Inflammatory Articular Reaction?
Solomon, L. B., Guevara, C. J., Büchler, L., Howie, D. W., Byard, R. W., & Beck, M. (2012) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-012-2457-6 · Cited by 24 · see citing works
Zhao, J., Bower, A. S., Yang, J., & Lin, X. (2018) · Nature Communications · doi:10.1038/s41467-018-04809-1 · Cited by 13 · see citing works
Effects of gelatin sponge implantation in cancellous bone defects in dogs
Howard, P. E., Wilson, J. W., & Ribble, G. A. (1988) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1988.192.05.633 · Cited by 9 · see citing works
Effective Bone Hemostasis and Healing Using Radiofrequency and Conductive Fluid
Bertone, A. L., Lipson, D., Kamei, J., Litsky, A. S., & Weisbrode, S. E. (2006) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000201163.97937.1a · Cited by 6 · see citing works
The effect of the new hemostatic agent Ostene® on bone healing: An experimental study in rabbits
Naser, A. I. (2018) · Journal Of Oral Research · doi:10.17126/joralres.2018.075 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Supramolecular Adhesive Hydrogels for Tissue Engineering Applications
Zhao, Y., Song, S., Ren, X., Zhang, J., Lin, Q., & Zhao, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00815 · Cited by 714 · see citing works
Engineered Hemostatic Biomaterials for Sealing Wounds
Montazerian, H., Davoodi, E., Baidya, A., Baghdasarian, S., Sarikhani, E., Meyer, C. E., Haghniaz, R., Badv, M., Annabi, N., Khademhosseini, A., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01015 · Cited by 296 · see citing works
A natural biological adhesive from snail mucus for wound repair
Deng, T., Gao, D., Song, X., Zhou, Z., Zhou, L., Tao, M., Jiang, Z., Yang, L., Luo, L., Zhou, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35907-4 · Cited by 289 · see citing works
Chitosan based bioadhesives for biomedical applications: A review
Hamedi, H., Moradi, S., Hudson, S. M., Tonelli, A. E., & King, M. W. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119100 · Cited by 281 · see citing works
Pan, G., Li, F., He, S., Li, W., Wu, Q., He, J., Ruan, R., Xiao, Z., Zhang, J., & Yang, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202200908 · Cited by 275 · see citing works
Li, S., Dong, Q., Peng, X., Chen, Y., Yang, H., Xu, W., Zhao, Y., Xiao, P., & Zhou, Y. (2022) · ACS Nano · doi:10.1021/acsnano.2c05069 · Cited by 251 · see citing works
Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications
K., A. D. V., Shyam, R., Palaniappan, A., Jaiswal, A. K., Oh, T.-H., & Nathanael, A. J. (2021) · Polymers · doi:10.3390/polym13213782 · Cited by 243 · see citing works
Functionalized Hydrogel-Based Wearable Gas and Humidity Sensors.
Luo, Y., Li, J., Ding, Q., Wang, H., Liu, C., & Wu, J. (2023) · Nano-Micro Letters · doi:10.1007/s40820-023-01109-2 · Cited by 236 · see citing works
“For different 1 3 application requirements, hydrogels can be functionalized to achieve specific properties and structures [64–66].”
BackgroundGuo, H., Huang, S., Xu, A., & Xue, W. (2022) · Chemistry of Materials · doi:10.1021/acs.chemmater.1c03944 · Cited by 204 · see citing works
Shear-thinning and self-healing chitosan-graphene oxide hydrogel for hemostasis and wound healing
Feng, W., & Wang, Z. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119824 · Cited by 185 · see citing works
Biofunctional chitosan–biopolymer composites for biomedical applications
Guo, Y., Qiao, D., Zhao, S., Liu, P., Xie, F., & Zhang, B. (2024) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2024.100775 · Cited by 178 · see citing works
Self-Healing Hydrogels: From Synthesis to Multiple Applications
Yin, H., Liu, F., Abdiryim, T., & Liu, X. (2023) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c00320 · Cited by 174 · see citing works
Emerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164 · see citing works
Self-citationDeng, L., Wang, B., Li, W., Han, Z., Chen, S., & Wang, H. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.017 · Cited by 134 · see citing works
Sun, L., Zhou, J., Lai, J., Zheng, X., Wang, H., Lü, B., Huang, R., & Zhang, L. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401030 · Cited by 131 · see citing works
Self-citationHuang, Y. P., Zhao, X., Wang, C., Chen, J., Liang, Y., Li, Z., Han, Y., & Guo, B. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131977 · Cited by 130 · see citing works
Application of Alginate-Based Hydrogels in Hemostasis
Xie, Y., Gao, P., He, F., & Zhang, C. (2022) · Gels · doi:10.3390/gels8020109 · Cited by 131 · see citing works
Xia, X., Xu, X., Wang, B., Zhou, D., Zhang, W., Xie, X. N., Lai, H., Ju, X., Rai, A., Li, Z., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202109332 · Cited by 127 · see citing works
Zhou, X., Ning, X., Chen, Y., Chang, H., Lu, D., Pei, D., Geng, Z., Zeng, Z., Guo, C., Huang, J., et al. (2023) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c00925 · Cited by 127 · see citing works
An injectable and self-healing cellulose nanofiber-reinforced alginate hydrogel for bone repair
Cui, S., Zhang, S., & Coseri, S. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120243 · Cited by 123 · see citing works
Wang, Y., Yang, M., & Zhao, Z. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120723 · Cited by 122 · see citing works
Li, Z., You, S., Mao, R., Xiang, Y., Cai, E., Deng, H., Shen, J., & Qi, X. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100264 · Cited by 121 · see citing works
Xie, M., Zeng, Y., Wu, H., Wang, S., & Zhao, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.166 · Cited by 121 · see citing works
Self-healing hydrogels as injectable implants: Advances in translational wound healing
Khattak, S., Ullah, I., Xie, H., Tao, X.-D., Xu, H., & Shen, J. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215790 · Cited by 117 · see citing works
Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering
Liang, Q., Xin, Y., Wu, X., & Ao, Q. (2022) · Polymers · doi:10.3390/polym14112184 · Cited by 110 · see citing works
Bio-macromolecular design roadmap towards tough bioadhesives
Montazerian, H., Davoodi, E., Baidya, A., Badv, M., Haghniaz, R., Dalili, A., Milani, A. S., Hoorfar, M., Annabi, N., Khademhosseini, A., et al. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00618a · Cited by 105 · see citing works
Liu, S., Jiang, N., Chi, Y., Peng, Q., Dai, G., Qian, L., Xu, K., Zhong, W., & Yue, W. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00321 · Cited by 103 · see citing works
Zhou, S., Xiao, C., Fan, L., Yang, J., Ge, R., Cai, M., Yuan, K., Li, C., Crawford, R., Xiao, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02320-y · Cited by 102 · see citing works
Tan, Y., Xu, C., Liu, Y., Bai, Y., Li, X., & Wang, X. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122147 · Cited by 101 · see citing works
Self-citationHemostatic biomaterials to halt non-compressible hemorrhage
Jiang, S., Liu, S., Lau, S., & Li, J. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00546h · Cited by 100 · see citing works
Bio-based and bio-inspired adhesives from animals and plants for biomedical applications
Lutz, T., Kımna, C., Casini, A., & Lieleg, O. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100203 · Cited by 97 · see citing works
Li, B., Li, H., Chen, H., Liu, Y., Chen, J., Feng, Q., Cao, X., & Dong, H. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202302793 · Cited by 98 · see citing works
Li, M., Shi, X., Yang, B., Qin, J., Han, X., Peng, W., He, Y., Mao, H., Kong, D., & Gu, Z. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119953 · Cited by 94 · see citing works
Fang, Y., Zhang, L., Chen, Y., Wu, S., Weng, Y., & Liu, H. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120819 · Cited by 94 · see citing works
Self-citationJiang, T., Chen, S., Xu, J., Zhang, Y., Fu, H., Ling, Q., Xu, Y., Chu, X., Wang, R., Hu, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49578-2 · Cited by 93 · see citing works
Self-citationChu, Z., Tian, T., Tao, Z., Yang, J., Chen, B., Chen, H., Wang, W., Yin, P., Xia, X., Wang, H., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.010 · Cited by 92 · see citing works
Si, R., Wang, Y., Yang, Y., Wu, Y. J., Wang, M., & Han, B. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151419 · Cited by 92 · see citing works
Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand
Mu, L., Wu, L., Wu, S., Ye, Q., & Zhong, Z. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122233 · Cited by 90 · see citing works
Kharaziha, M., Scheibel, T., & Salehi, S. (2024) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2024.101792 · Cited by 90 · see citing works
Nanocellulose based hydrogel for flexible sensors: Current progress and future perspective
Wang, Z., Zhu, M., Li, J., Hu, C., Li, J., Xiong, R., & Huang, C. (2024) · Nano Energy · doi:10.1016/j.nanoen.2024.109974 · Cited by 86 · see citing works
Liu, Y., Niu, H., Wang, C., Yang, X., Li, W., Zhang, Y., Ma, X., Xu, Y., Zheng, P., Wang, J., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.025 · Cited by 84 · see citing works
Self-citationCheng, J., Liu, J. F., Li, M., Liu, Z., Wang, X., Zhang, L., & Wang, Z. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.780187 · Cited by 82 · see citing works
Self-citationEngineering functional natural polymer-based nanocomposite hydrogels for wound healing
Wang, M., Deng, Z., Guo, Y. C., & Xu, P. (2022) · Nanoscale Advances · doi:10.1039/d2na00700b · Cited by 82 · see citing works
Xu, Z., Tian, W., Wen, C., Ji, X., Diao, H., Hou, Y., Fan, J., Liu, Z., Ji, T., Sun, F., et al. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c02144 · Cited by 81 · see citing works
Multifunctional Adhesive Hydrogels: From Design to Biomedical Applications
Tang, S., Feng, K., Yang, R., Yang, C., Chen, M., Zhang, H., Shi, N., Wei, Z., Ren, H. P., & Ma, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403734 · Cited by 81 · see citing works
Xu, K., Deng, S., Zhu, Y., Yang, W., Chen, W., Huang, L., Zhang, C., Li, M., Ao, L., Jiang, Y., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301370 · Cited by 80 · see citing works
Self-citationKhan, M. U. A., Aslam, M. A., Abdullah, M. F., & Stojanović, G. M. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00362 · Cited by 78 · see citing works
Shen, Q., Qi, Y., Kong, Y., Bao, H., Wang, Y., Dong, A., Wu, H., & Xu, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.795425 · Cited by 76 · see citing works
Lu, S., Wu, H., Ge, S., Huang, L., Chen, L., Connor, C., Guo, Z., Jiang, Y., Xu, B. B., & Peng, W. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304676 · Cited by 73 · see citing works
Self-citationLi, L., Yang, C., Ma, B., Lu, S., Liu, J., Pan, Y., Wang, X., Zhang, Y., Wang, H., Sun, T., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c20399 · Cited by 72 · see citing works
Self-citationAdvances in adhesive hydrogels for tissue engineering
Yang, J. Z., Yu, H., Wang, L., Liu, J., Liu, X., Hong, Y., Huang, Y., & Ren, S. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111241 · Cited by 70 · see citing works
Chen, X., Tao, J., Zhang, M., Lu, Z., Yang, Y. L., Song, P., Wang, T., Jiang, T., & Zhao, X. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120123 · Cited by 70 · see citing works
Advances and Progress in Self-Healing Hydrogel and Its Application in Regenerative Medicine
Zhu, W., Zhang, J., Wei, Z., Zhang, B., & Weng, X. (2023) · Materials · doi:10.3390/ma16031215 · Cited by 69 · see citing works
Tough, Antifreezing, and Conductive Hydrogel Based on Gelatin and Oxidized Dextran
Cao, L., Zhao, Z., Wang, X., Huang, X., Li, J., & Wei, Y. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202101382 · Cited by 68 · see citing works
Self-citationConjugated polymer-based composite scaffolds for tissue engineering and regenerative medicine
Biglari, N., & Zare, E. N. (2023) · Alexandria Engineering Journal · doi:10.1016/j.aej.2023.12.041 · Cited by 66 · see citing works
Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children
Zhang, Z., Li, H., Qian, M., Zheng, Y., Bao, L., Cui, W., & Wang, D. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf004 · Cited by 65 · see citing works
Xie, Y., Li, G., Wu, J., Zhu, J., Cai, X., Zhao, P., Zhang, D., & Zhong, Y. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122864 · Cited by 59 · see citing works
Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization
Yang, R., Zhang, X., Chen, B., Yan, Q., Yin, J., & Luan, S. (2023) · Nature Communications · doi:10.1038/s41467-023-41610-1 · Cited by 58 · see citing works
Mussel‐mimetic polysaccharide‐based injectable hydrogels for biomedical applications
Fan, Y., Zheng, L., Jin, M. Y., Li, X., Li, Z. A., & Wang, X. (2024) · BMEMat · doi:10.1002/bmm2.12089 · Cited by 58 · see citing works
Self-citationConformal Fixation Strategies and Bioadhesives for Soft Bioelectronics
Park, J., Kim, H. W., Lim, S., Yi, H., Wu, Z., Kwon, I. G., Yeo, W., Song, E., & Yu, K. J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202313728 · Cited by 58 · see citing works
Zhang, M., Zhang, Q., Chen, X., Jiang, T., Song, P., Wang, B., & Zhao, X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.165 · Cited by 55 · see citing works
Li, Y., Cheng, S., Wen, H., Xiao, L., Deng, Z., Huang, J., & Zhang, Z. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.020 · Cited by 54 · see citing works
Self-citationWang, Z., Chu, Y., Du, J., Hu, Y., Wang, H., Liu, H., Yang, C., Wang, M., Ran, J., & Yu, A. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123082 · Cited by 54 · see citing works
Wang, Y., Feng, Z., Liu, X., Yang, C., Gao, R., Liu, W., Ouyang, W., Dong, A., Zhang, C., Huang, P., et al. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac003 · Cited by 53 · see citing works
Chu, Z., Chen, H., Wang, P., Wang, W., Yang, J., Sun, J., Chen, B., Tian, T., Zha, Z., Wang, H., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c00854 · Cited by 53 · see citing works
Huang, X., Lan, Y., Shen, J., Zhao, X., Zhou, Y., Wu, W., Mao, J., Wu, Y., Xie, Z., & Chen, Z. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.005 · Cited by 53 · see citing works
Textile-Based Mechanical Sensors: A Review
Zhou, Z., Chen, N., Zhong, H., Zhang, W., Zhang, Y., Yin, X., & He, B. (2021) · Materials · doi:10.3390/ma14206073 · Cited by 52 · see citing works
Self-citationAdvanced functional chitosan-based nanocomposite materials for performance-demanding applications
Guo, Y., Qiao, D., Zhao, S., Zhang, B., & Xie, F. (2024) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2024.101872 · Cited by 52 · see citing works
He, Y., Liu, K., Zhang, C., Guo, S., Chang, R., Guan, F., & Yao, M. (2022) · Biomaterials Science · doi:10.1039/d2bm00891b · Cited by 51 · see citing works
Wei, H., Yu, S., Zhang, Y., Zhang, H., Ma, Y., Xu, M., An, P., Zhou, Y., Halila, S., Wei, Y., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120904 · Cited by 51 · see citing works
Self-citationHu, S., Wang, S., He, Q., Li, D., Xin, L., Xu, C., Zhu, X., Li, M., Cannon, R. D., Ji, P., et al. (2023) · Advanced Science · doi:10.1002/advs.202206450 · Cited by 50 · see citing works
Magnesium Nanocomposite Hydrogel Reverses the Pathologies to Enhance Mandible Regeneration
Guo, J., Yao, H., Chang, L., Zhu, W., Zhang, Y., Li, X., Yang, B., Dai, B., Chen, X., Lei, L., et al. (2024) · Advanced Materials · doi:10.1002/adma.202312920 · Cited by 50 · see citing works
Self-citationOuyang, L., Chen, B., Liu, X., Wang, D., Li, Y., Liao, Y. J., Yeung, K., & Liu, X. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.005 · Cited by 49 · see citing works
Jing, Y., Ruan, L., Jiang, G., Nie, L., Shavandi, A., Sun, Y., Xu, J., Shao, X., & Zhu, J. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213405 · Cited by 49 · see citing works
Pan, S., Li, Y., Tong, X., Chen, L., Wang, L., Li, T., & Zhang, Q. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120324 · Cited by 48 · see citing works
Self-citationQi, H., Yang, L., Ma, R., Xiang, Y., Dai, Y., Ren, J., Xu, B. B., El-Bahy, Z. M., Thabet, H. K., Huang, Z., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135701 · Cited by 46 · see citing works
Zhao, W., Zhang, Z., Hu, J. S., Feng, X., Xu, J., Wu, Y., & Yan, S. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137305 · Cited by 46 · see citing works
Li, Q., Hu, E., Yu, K., Xie, R., Lu, F., Lu, B., Bao, R., Dai, F., & Lan, G. (2023) · Advanced Fiber Materials · doi:10.1007/s42765-023-00280-w · Cited by 45 · see citing works
Rational Design of Bioactive Materials for Bone Hemostasis and Defect Repair
Gai, Y., Yin, Y., Guan, L., Zhang, S., Chen, J., Yang, J., Zhou, H., & Li, J. (2023) · Cyborg and Bionic Systems · doi:10.34133/cbsystems.0058 · Cited by 45 · see citing works
Chitosan-based biomaterials for bone tissue engineering
Li, Y., Li, X., Zhu, L., Liu, T., & Huang, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140923 · Cited by 46 · see citing works
Feng, Y., Yu, Z., Liu, H., Guan, L., Yang, X., Zvyagin, A. V., Zhao, Y., Yang, X., Yang, B. J., & Lin, Q. (2023) · Materials Today · doi:10.1016/j.mattod.2023.10.011 · Cited by 43 · see citing works
Recent advances in zwitterionic hydrogels: structure, applications and challenges
Wang, Z., Liu, X., Zhu, M., Yang, J., Tao, S., Gong, Z., Xu, M. H., & Pan, L. (2025) · Journal of Materials Chemistry A · doi:10.1039/d5ta01111f · Cited by 44 · see citing works
Liu, H., Deng, Z., Li, T., Bu, J., De, W., Wang, J., Liu, M., Li, J., Yang, Y., & Zhong, S. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112703 · Cited by 43 · see citing works
Functional hydrogels for the repair and regeneration of tissue defects
Li, X., Xu, M., Geng, Z., & Liu, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1190171 · Cited by 44 · see citing works
Huang, Q., Hu, Y., Chen, Y., Zhou, M., Zhang, Y., Sun, Z., & Chen, Z. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123136 · Cited by 43 · see citing works
Self-citationLiu, Z., Ding, Y., Ding, Y. F., Wang, W., Mao, Z., & Yu, L. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.123038 · Cited by 45 · see citing works
Blood-triggered self-sealing and tissue adhesive hemostatic nanofabric
Fang, Y., Wang, L., Zheng, X., Ni, P., Xu, Z., Wang, Z., Weng, Y., Chen, Q., & Liu, H. (2025) · Nature Communications · doi:10.1038/s41467-025-60244-z · Cited by 42 · see citing works
Xiao, C., Wang, R., Fu, R., Yu, P., Guo, J., Li, G., Wang, Z., Wang, H., Nie, J., Liu, W., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.01.003 · Cited by 41 · see citing works
Yao, K., Li, S., Zheng, X., Zhang, Q., Liu, J., Liang, C., Duan, K., Ye, J., Yin, Y., & Chen, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.148770 · Cited by 41 · see citing works
Degradable Nanohydroxyapatite-Reinforced Superglue for Rapid Bone Fixation and Promoted Osteogenesis
Yang, R., Chen, B., Zhang, X., Bao, Z., Yan, Q., & Luan, S. (2024) · ACS Nano · doi:10.1021/acsnano.4c01214 · Cited by 41 · see citing works
Fracture‐Resistant Stretchable Materials: An Overview from Methodology to Applications
Guo, X., Dong, Y., Qin, J., Zhang, Q., Zhu, H., & Zhu, S. (2024) · Advanced Materials · doi:10.1002/adma.202312816 · Cited by 42 · see citing works
Tang, J., Li, H., Peng, H., Zhang, Z., Liu, C., Cheng, Y., Wang, K., Yu, Z., Lyu, Z., Zhang, J., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100498 · Cited by 41 · see citing works
Jie, X., Shiu, B., Zhang, Y., Wu, H., Ye, Y., & Fang, R. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120792 · Cited by 41 · see citing works
Self-citationWang, X., Zhang, X., Yang, X., Guo, X., Liu, Y., Li, Y., Ding, Z., Teng, Y., Hou, S., Shi, J., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c19662 · Cited by 40 · see citing works
Self-citationZhao, G., Zhang, A., Chen, X., Xiang, G., Jiang, T., & Zhao, X. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.07.011 · Cited by 40 · see citing works
Li, B., Li, C., Yan, Z., Yang, X., Xiao, W., Zhang, D., Liu, Z., & Liao, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138323 · Cited by 40 · see citing works
Wang, C., Lu, Y., Cui, H., & Tan, Y. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143354 · Cited by 40 · see citing works
Ma, W., Chen, H., Cheng, S., Wu, C., Wang, L., & Du, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124287 · Cited by 39 · see citing works
Self-citationBioactive hydrogels based on polysaccharides and peptides for soft tissue wound management
Wu, L., He, Y., Mao, H., & Gu, Z. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00591c · Cited by 39 · see citing works
Design and Applications of Dynamic Hydrogels Based on Reversible C═N Bonds
Yang, H., & Fustin, C. (2023) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202300211 · Cited by 38 · see citing works
- Authors
- Huang, W., Cheng, S., Wang, X., Zhang, Y., Chen, L., & Zhang, L.
- Affiliations
- South China Agricultural University (CN)
- Guangdong Academy of Medical Sciences (CN)
- University of Alberta (CA)
- Wuhan University (CN)
- Corresponding author
- Zhang, Yu
- Chen, Lingyun
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2021-02-28
- Volume
- 31
- Issue
- 22
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3133980713
- Cited by
- 272
- References
- 51
- Citations by year
- 2026: 26 · 2025: 57 · 2024: 72 · 2023: 50 · 2022: 58 · 2021: 9
- FWCI
- 30.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- National Natural Science Foundation of China (31700880, 31771038)
- Topics
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- hemostasis, bone regeneration, self-healing hydrogels, bioadhesive hydrogel, bone defects, injectable hydrogel, hemocompatibility, tissue adhesion, bone tumor resection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review