The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Chitosan film containing antifungal agent-loaded SLNs for the treatment of candidiasis using a Box-Behnken design
Abstract
The aim of this study was to combine fluconazole (FZ)-loaded solid lipid nanoparticles (FZ-SLNs) and chitosan films (C-films) for the potential administration of FZ across the buccal mucosa using a Box-Behnken design. The chitosan films containing FZ-SLNs (C-FS-films) and C-films were prepared using a film casting method. The ATR-FTIR analysis confirmed the presence of hydrogen bonds between the NH 3+ groups of chitosan and the OH or COO- groups of glyceryl monostearate in the films. Additionally, FESEM analysis of the morphology of C-FS-films revealed the presence of FZ-SLNs in the films. Permeation studies using porcine buccal mucosa demonstrated that FZ from the C-FS-films was more permeable than in C-films. The antifungal activity of the C-FS-films was evaluated against Candida albicans, and inhibition zones were observed. Thus, C-FS-films represent an exciting drug carrier for the treatment of candidiasis via the buccal mucosa.
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Manufacture and characterization of mucoadhesive buccal films
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Buccal penetration enhancers—How do they really work?
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e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7
Metadata
- Authors
- Kraisit, P., Yonemochi, E., Furuishi, T., Mahadlek, J., & Limmatvapirat, S.
- Affiliations
- Thammasat University (TH)
- Hosei University (JP)
- Silpakorn University (TH)
- Corresponding author
- Kraisit, Pakorn
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 283
- Pages
- 119178
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4206964647
- Cited by
- 36
- References
- 47
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 11
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Keywords
- chitosan films, solid lipid nanoparticles, fluconazole, candidiasis, Candida albicans, buccal permeation, antifungal activity, Box-Behnken design, glyceryl monostearate, film casting, drug carriers
- MeSH terms
- Adhesiveness, Administration, Buccal, Animals, Antifungal Agents, Candida albicans, Candidiasis, Drug Carriers, Glycerides, Liposomes, Mouth Mucosa, Particle Size, Swine, Fluconazole, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, Chitosan, Nanoparticles
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