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Chitosan film containing antifungal agent-loaded SLNs for the treatment of candidiasis using a Box-Behnken design
Abstract
The aim of this study was to combine fluconazole (FZ)-loaded solid lipid nanoparticles (FZ-SLNs) and chitosan films (C-films) for the potential administration of FZ across the buccal mucosa using a Box-Behnken design. The chitosan films containing FZ-SLNs (C-FS-films) and C-films were prepared using a film casting method. The ATR-FTIR analysis confirmed the presence of hydrogen bonds between the NH 3+ groups of chitosan and the OH or COO- groups of glyceryl monostearate in the films. Additionally, FESEM analysis of the morphology of C-FS-films revealed the presence of FZ-SLNs in the films. Permeation studies using porcine buccal mucosa demonstrated that FZ from the C-FS-films was more permeable than in C-films. The antifungal activity of the C-FS-films was evaluated against Candida albicans, and inhibition zones were observed. Thus, C-FS-films represent an exciting drug carrier for the treatment of candidiasis via the buccal mucosa.
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Danaei, M., Dehghankhold, M., Ataei, S., Davarani, F. H., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10020057 · Cited by 5,199
Preparation and properties of rice starch–chitosan blend biodegradable film
Bourtoom, T., & Chinnan, M. S. (2007) · LWT · doi:10.1016/j.lwt.2007.10.014 · Cited by 589
Manufacture and characterization of mucoadhesive buccal films
Morales, J. O., & McConville, J. T. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.11.023 · Cited by 477
Ren, L., Yan, X., Zhou, J., et al. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.02.008 · Cited by 469
Branca, C., D’Angelo, G., Crupi, C., Khouzami, K., Rifici, S., Ruello, G., & Wanderlingh, U. (2016) · Polymer · doi:10.1016/j.polymer.2016.07.086 · Cited by 404
Regulation of multidrug resistance in pathogenic fungi
Morschhäuser, J. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.08.002 · Cited by 300
Hu, D., Wang, H., & Wang, L. (2015) · LWT · doi:10.1016/j.lwt.2015.08.033 · Cited by 242
Buccal penetration enhancers—How do they really work?
Nicolazzo, J. A., Reed, B. L., & Finnin, B. C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.01.024 · Cited by 201
Sahraee, S., Milani, J. M., Ghanbarzadeh, B., et al. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.12.066 · Cited by 200
El-Housiny, S., Eldeen, M. A. S., El-Attar, Y. A., et al. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1413444 · Cited by 196
Vaghasiya, H., Kumar, A., & Sawant, K. K. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.03.013 · Cited by 173
Mucoadhesive chitosan/gelatin films for buccal delivery of propranolol hydrochloride
Abruzzo, A., Bigucci, F., Cerchiara, T., et al. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.08.024 · Cited by 166
Lian, H., Peng, Y., Shi, J., & Wang, Q. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105213 · Cited by 152
Brandelero, R. P. H., Yamashita, F., & Grossmann, M. V. E. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.06.034 · Cited by 148
Topical Amphotericin B solid lipid nanoparticles: Design and development
Butani, D., Yewale, C. R., & Misra, A. R. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.032 · Cited by 143
Al‐Kassas, R., Wen, J., Cheng, A. E.-M., Kim, A. M.-J., Liu, S. S. M., & Joohee, Y. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.06.096 · Cited by 139
Giovino, C., Ayensu, I., Tetteh, J., & Boateng, J. S. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.07.019 · Cited by 127
Hossain, F., Follett, P. A., Salmieri, S., et al. (2019) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2019.02.009 · Cited by 122
Mo, X., Peng, X., Liang, X., et al. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.106506 · Cited by 121
Rençber, S., Karavana, S. Y., Yılmaz, F. F., Eraç, B., Nenni, M., Özbal, S., Pekçetin, Ç., Gürer-Orhan, H., Limoncu, M. H., Güneri, P., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s103762 · Cited by 110
Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers
Pillai, O., Nair, V. B., & Panchagnula, R. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.032 · Cited by 108
Enhanced permeation of triamcinolone acetonide through the buccal mucosa
Shin, S. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00101-6 · Cited by 93
Kai, T., Mak, V. H. W., Potts, R. O., et al. (1990) · Journal of Controlled Release · doi:10.1016/0168-3659(90)90086-9 · Cited by 92
Buccal administration of mucoadhesive blend films saturated with propranolol loaded nanoparticles
Kraisit, P., Limmatvapirat, S., Luangtana‐anan, M., & Sriamornsak, P. (2017) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.07.006 · Cited by 92
Self-citationRabey, H. A. E., Almutairi, F. M., Alalawy, A. I., Al-Duais, M. A., Sakran, M., Zidan, N. S., & Tayel, A. A. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.036 · Cited by 74
Trastullo, R., Abruzzo, A., Saladini, B., et al. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.05.026 · Cited by 72
Morales, J. O., Huang, S., Williams, R. O., & McConville, J. T. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.05.025 · Cited by 69
Improved yeast delivery of fluconazole with a nanostructured lipid carrier system
Kelidari, H., Moazeni, M., Babaei, R., Saeedi, M., Âkbari, J., Parkoohi, P. I., Nabili, M., Gohar, A. A., Morteza‐Semnani, K., & Nokhodchi, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.008 · Cited by 67
Solvent exchange-induced in situ forming gel comprising ethyl cellulose-antimicrobial drugs
Phaechamud, T., & Mahadlek, J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.08.047 · Cited by 66
Self-citationNovel strategies for the buccal delivery of macromolecules
Morales, J. O., & McConville, J. T. (2014) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2014.892960 · Cited by 65
Kundu, J., Patra, C., & Kundu, S. C. (2008) · Materials Science and Engineering C · doi:10.1016/j.msec.2008.03.004 · Cited by 64
Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug
Soe, M. T., Pongjanyakul, T., Limpongsa, E., et al. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116556 · Cited by 64
Potaś, J., Szymańska, E., Wróblewska, M., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101588 · Cited by 59
Kraisit, P., Hirun, N., Mahadlek, J., & Limmatvapirat, S. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102437 · Cited by 57
Self-citationKraisit, P., Limmatvapirat, S., Nunthanid, J., Sriamornsak, P., & Luangtana‐anan, M. (2016) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c16-00849 · Cited by 53
Self-citationShah, R., Eldridge, D. S., Palombo, E. A., et al. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.04.007 · Cited by 53
Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis
Rençber, S., Karavana, S. Y., Yılmaz, F. F., Eraç, B., Nenni, M., Gürer-Orhan, H., Limoncu, M. H., Güneri, P., & Ertan, G. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.12.035 · Cited by 50
Biocompatible Polyurethane Scaffolds Prepared from Glycerol Monostearate-Derived Polyester Polyol
Ng, W. S., Lee, C. S., Cheng, S. F., et al. (2018) · Journal of Polymers and the Environment · doi:10.1007/s10924-017-1175-2 · Cited by 47
Tzanova, M. M., Hagesæther, E., & Tho, I. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.120100 · Cited by 46
Modification of buccal drug delivery following pretreatment with skin penetration enhancers
Nicolazzo, J. A., Reed, B. L., & Finnin, B. C. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20113 · Cited by 43
Nanoparticle formation by using shellac and chitosan for a protein delivery system
Kraisit, P., Limmatvapirat, S., Nunthanid, J., et al. (2012) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2012.685657 · Cited by 39
Self-citationPongjanyakul, T., Khunawattanakul, W., Strachan, C. J., et al. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.12.043 · Cited by 29
Protein-coated nanoparticles embedded in films as delivery platforms
Morales, J. O., Ross, A. C., & McConville, J. T. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12046 · Cited by 28
Huang, J., Jacobsen, J., Larsen, S. W., et al. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119811 · Cited by 28
Tejada, G., Lamas, M. C., Svetaz, L. A., et al. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.023 · Cited by 27
Monitoring Surfactant-Induced Hemolysis by Surface Tension Measurement
Shalel, S., Streichman, S., & Marmur, A. (2002) · Journal of Colloid and Interface Science · doi:10.1006/jcis.2002.8621 · Cited by 21
Development and evaluation of a buccal bioadhesive system for smoking cessation therapy
Garg, S., Garg, S., & Kumar, G. S. (2007) · Die Pharmazie · doi:10.31083/ph.2007.4.6144 · Cited by 20
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Metadata
- Authors
- Kraisit, P., Yonemochi, E., Furuishi, T., Mahadlek, J., & Limmatvapirat, S.
- Affiliations
- Thammasat University (TH)
- Hosei University (JP)
- Silpakorn University (TH)
- Corresponding author
- Kraisit, Pakorn
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 283
- Pages
- 119178
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4206964647
- Cited by
- 36
- References
- 47
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 11
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Keywords
- chitosan films, solid lipid nanoparticles, fluconazole, candidiasis, Candida albicans, buccal permeation, antifungal activity, Box-Behnken design, glyceryl monostearate, film casting, drug carriers
- MeSH terms
- Adhesiveness, Administration, Buccal, Animals, Antifungal Agents, Candida albicans, Candidiasis, Drug Carriers, Glycerides, Liposomes, Mouth Mucosa, Particle Size, Swine, Fluconazole, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, Chitosan, Nanoparticles
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