The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Hyaluronic acid-based minocycline-loaded dissolving microneedle: Innovation in local minocycline delivery for periodontitis
Abstract
Periodontitis is a prevalent inflammatory disease that affects tooth-supporting tissues and is induced by complex polymicrobial dental plaques. Prior treatments, including topical antibiotic ointments, have faced difficulties in tissue permeability issues. Although dissolving microneedle (DMN) has been proposed as a painless and highly efficient transdermal drug delivery system to resolve this challenge, minocycline, widely used for the treatment of periodontitis, is light-sensitive, making it challenging to maintain its stability using conventional fabrication methods. Our hyaluronic acid-based minocycline-loaded dissolving microneedle (HAM-DMN) was designed utilizing an innovative light-blocking strategy, preserving 94.4 % of minocycline's stability, as confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. HAM-DMNs demonstrated antimicrobial efficacy in in vitro zone of inhibition tests with Streptococcus mutans strains and provided enhanced local delivery of minocycline to porcine oral gingival mucosa at concentrations 6.1 times higher than those of commercial ointments. In vivo studies in periodontitis-induced rat models showed that HAM-DMNs reduced levels of junctional epithelium more effectively than control and blank DMN groups, indicating enhanced treatment efficacy. HAM-DMN is a novel local delivery system developed to overcome the limitations of systemic delivery and conventional topical treatment. We suggest that HAM-DMNs can replace inje…
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“Applying this technology to deliver MNC topically reduces the systemic exposure and bacterial resistance without affecting the normal flora in the gastrointestinal tract. Also, avoids the problematic adverse effects of this drug and enhances the bioavailability due to eliminating the first pass metabolism [27,28,29,30].”
From Formulation and Characterization of PLGA Minocycline Microneedles for Enhanced Skin Deposition and Antibacterial Activity in Acne Treatment (2025) · cites this paper as [29]
In the citing paper
“This is consistent with previous observations that minocycline can maintain most of its chemical integrity under dark or low-light conditions in dissolving microneedle formulations, even in the absence of MOF-based protection [36].”
From Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy (2026) · cites this paper as [36]
Citations
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Cited by
DNAzyme@MOF breaking pH limitation for the detection of dopamine in the interstitial fluid
Zhao, J., Zhao, J., Zhang, X., Ling, G., & Zhang, P. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117367 · Cited by 24
Nanozymes Empower Periodontitis Treatment: New Strategies and Clinical Application Prospects
Xu, Y., Yan, J., Cui, C., Zhou, L., Zhang, K., Du, M., Gong, Y., Zhang, Z., Wu, X., & Li, B. (2025) · Biomaterials Research · doi:10.34133/bmr.0210 · Cited by 22
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Cementum regeneration strategies: Insights from development and periodontal microenvironment
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Metadata
- Authors
- Song, Y. W., Nam, J., Kim, J., Lee, Y., Choi, J., Min, H. S., Yang, H., Cho, Y., Hwang, S., Son, J., Jung, U.-W., & Jung, H.
- Affiliations
- Veterans Health Service Medical Center (KR)
- Yonsei University (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Jung, Ui-Won
- Jung, Hyungil
- ORCID
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2025-02
- Volume
- 349
- Issue
- Pt B
- Pages
- 122976
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4404294001
- Semantic Scholar
- 4ab45a73d81d6da87b56eab93c2ae78d4b69cfd2
- Cited by
- 33
- References
- 52
- Citations by year
- 2026: 21 · 2025: 12
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- periodontitis, minocycline, dissolving microneedles, hyaluronic acid, transdermal drug delivery, local antibiotic delivery, Streptococcus mutans, gingival mucosa, junctional epithelium, periodontal treatment
- MeSH terms
- Animals, Anti-Bacterial Agents, Hyaluronic Acid, Male, Minocycline, Needles, Periodontitis, Streptococcus mutans, Swine, Drug Delivery Systems, Rats, Sprague-Dawley, Rats
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- This page
- CoChat. (2026). Citation check: Hyaluronic acid-based minocycline-loaded dissolving microneedle: Innovation in local minocycline delivery for periodontitis. https://app.cochat.ai/papers/10.1016/j.carbpol.2024.122976
- The paper
- Song, Y. W., Nam, J., Kim, J., Lee, Y., Choi, J., Min, H. S., Yang, H., Cho, Y., Hwang, S., Son, J., Jung, U.-W., & Jung, H. (2025). Hyaluronic acid-based minocycline-loaded dissolving microneedle: Innovation in local minocycline delivery for periodontitis. Carbohydrate Polymers. https://doi.org/10.1016/j.carbpol.2024.122976
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
