The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Protein kinase activation and myocardial ischemia/reperfusion injury
Abstract
Myocardial ischemia and ischemia/reperfusion activate several protein kinase pathways. Protein kinase activation potentially regulates the onset of myocardial cell injury and the reduction of this injury by ischemic and pharmacologic preconditioning. The primary protein kinase pathways that are potentially activated by myocardial ischemia/reperfusion include: the MAP kinases, ERK 1/2, JNK 1/2, p38 MAPKalpha/beta; the cell survival kinase, Akt; and the sodium-hydrogen exchanger (NHE) kinase, p90RSK. The literature does not support a role for ischemia/reperfusion in the activation of the tyrosine kinases, Src and Lck, or the translocation and activation of PKC. This review will detail the role of these protein kinases in the onset of myocardial cell death by necrosis and apoptosis and the reduction of this injury by preconditioning.
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Cites
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Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
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MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α
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Ischemic Preconditioning Activates Phosphatidylinositol-3-Kinase Upstream of Protein Kinase C
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Cited by
Ferdinandy, P., Schulz, R., & Baxter, G. F. (2007) · Pharmacological Reviews · doi:10.1124/pr.107.06002 · Cited by 744
Survival kinases in ischemic preconditioning and postconditioning
HAUSENLOY, D., & YELLON, D. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.017 · Cited by 472
The role of mitochondria in protection of the heart by preconditioning
Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390
Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
Gurusamy, N., Lekli, I., Mukherjee, S., Ray, D., Ahsan, M. K., Gherghiceanu, M., Popescu, L. M., & Das, D. K. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvp384 · Cited by 263
Ischemic Postconditioning in Pigs: No Causal Role for RISK Activation
Skyschally, A., van Caster, P., Boengler, K., Gres, P., Musiolik, J., Schilawa, D., Schulz, R., & Heusch, G. (2009) · Circulation Research · doi:10.1161/circresaha.108.186429 · Cited by 255
Metadata
- Authors
- Armstrong, S.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-15
- Volume
- 61
- Issue
- 3
- Pages
- 427-436
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2131755434
- Cited by
- 334
- References
- 58
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
