The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
Open accessAbstract
The Akt family of serine/threonine-directed kinases promotes cellular survival in part by phosphorylating and inhibiting death-inducing proteins. Here we describe a novel functional interaction between Akt and apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase. Akt decreased ASK1 kinase activity stimulated by both oxidative stress and overexpression in 293 cells by phosphorylating a consensus Akt site at serine 83 of ASK1. Activation of the phosphoinositide 3-kinase (PI3-K)/Akt pathway also inhibited the serum deprivation-induced activity of endogenous ASK1 in L929 cells. An association between Akt and ASK1 was detected in cells by coimmunoprecipitation. Phosphorylation by Akt inhibited ASK1-mediated c-Jun N-terminal kinase and activating transcription factor 2 activities in intact cells. Finally, activation of the PI3-K/Akt pathway reduced apoptosis induced by ASK1 in a manner dependent on phosphorylation of serine 83 of ASK1. These results provide the first direct link between Akt and the family of stress-activated kinases.
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Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
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Cited by
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
Cellular processing of platinum anticancer drugs
Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781
The protein kinase B/Akt signalling pathway in human malignancy
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Metadata
- Authors
- Kim, A. H., Khursigara, G., Sun, X., Franke, T. F., & Chao, M. V.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-02
- Volume
- 21
- Issue
- 3
- Pages
- 893-901
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2123619341
- Cited by
- 709
- References
- 4
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, A. H., Khursigara, G., Sun, X., Franke, T. F., & Chao, M. V. (2001). Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.3.893-901.2001
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