The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gap junctions and connexin-interacting proteins
Abstract
Gap junctions form channels between adjacent cells. The core proteins of these channels are the connexins. Regulation of gap junction communication (GJC) can be modulated by connexin-associating proteins, such as regulatory protein phosphatases and protein kinases, of which c-Src is the best-studied. Structural proteins, notably zona occludens-1 (ZO-1) and microtubules, have been found recently at gap junctions. Along with the expansion of the list of connexin-associating proteins, reports have appeared that suggest that connexins might have additional roles in addition to their channel function, such as transcriptional and cytoskeletal regulation. Here, gap junction interacting proteins are reviewed and their function is addressed. The striking similarity of proteins present at the cytoplasmic face of tight junctions, adherens junctions and gap junctions and their possible role in gene transcription and cytoskeletal anchorage is highlighted.
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Cites
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
Itoh, M., Nagafuchi, A., Moroi, S., & Tsukita, S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.1.181 · Cited by 677
Cited by
Molecular mechanosensors in osteocytes
Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484
Xie, H., Vucetic, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Obradovic, Z., & Uversky, V. N. (2007) · Journal of Proteome Research · doi:10.1021/pr060394e · Cited by 382
Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261
“Besides its participation in gap junctions and hemichannels, Cx43 might also affect osteoblast and osteocyte functions by interacting with structural and signaling molecules, thereby modulating intracellular signaling and gene expression.((14)) One of the best-studied Cx43-interacting proteins is the kinase Src, an up…”
BackgroundNagasawa, K., Chiba, H., Fujita, H., Kojima, T., Saito, T., Endo, T., & Sawada, N. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20647 · Cited by 255
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia
Flenniken, A. M., Osborne, L. R., Anderson, N., Ciliberti, N., Fleming, C., Gittens, J. E. I., Gong, X.-Q., Kelsey, L. B., Lounsbury, C., Moreno, L., et al. (2005) · Development · doi:10.1242/dev.02011 · Cited by 231
Metadata
- Authors
- Giepmans, B.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-05-01
- Volume
- 62
- Issue
- 2
- Pages
- 233-245
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2050844532
- Cited by
- 450
- References
- 2
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
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