Molecular mechanosensors in osteocytes

Role of YAP/TAZ in mechanotransduction

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Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

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Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

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Environmental sensing through focal adhesions

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The amazing osteocyte

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Bone “mass” and the “mechanostat”: A proposal

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

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Das Gesetz der Transformation der Knochen

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The mechanisms of Hedgehog signalling and its roles in development and disease

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Integrins

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Mechanobiology of YAP and TAZ in physiology and disease

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Regulation of bone mass by Wnt signaling

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Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

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Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

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Fracture healing under healthy and inflammatory conditions

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Functional atlas of the integrin adhesome

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Building strong bones: molecular regulation of the osteoblast lineage

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Osteocytes, mechanosensing and Wnt signaling

Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076 · see citing works

The Osteocyte: An Endocrine Cell … and More

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Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

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Integrin signalling at a glance

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Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

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SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771 · see citing works

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

Lin, C., Jiang, X., Dai, Z., Guo, X., Weng, T., Wang, J., Li, Y., Feng, G., Gao, X., & He, L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090411 · Cited by 631 · see citing works

Structure and mechanogating mechanism of the Piezo1 channel

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Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.Preprint

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TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation

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Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts

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Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis

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Identification of senescent cells in the bone microenvironment

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An Introductory Review of Cell Mechanobiology

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Improved Bone Structure and Strength After Long-Term Mechanical Loading Is Greatest if Loading Is Separated Into Short Bouts

Robling, A. G., Hinant, F. M., Burr, D. B., & Turner, C. H. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.8.1545 · Cited by 551 · see citing works

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Wang, L., You, X., Lotinun, S., Zhang, L., Wu, N., & Zou, W. (2020) · Nature Communications · doi:10.1038/s41467-019-14146-6 · Cited by 535 · see citing works

Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone

Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works

Osteocytes: master orchestrators of bone

Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514 · see citing works

Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial

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Mechanical Strain Opens Connexin 43 Hemichannels in Osteocytes: A Novel Mechanism for the Release of Prostaglandin

Cherian, P. P., Siller-Jackson, A. J., Gu, S., Wang, X., Bonewald, L. F., Sprague, E., & Jiang, J. X. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0912 · Cited by 481 · see citing works

Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism

Malone, A. M. D., Anderson, C. T., Tummala, P., Kwon, R. Y., Johnston, T. R., Stearns, T., & Jacobs, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700636104 · Cited by 477 · see citing works

Mechanical loading thresholds for lamellar and woven bone formation

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Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Tu, X., Rhee, Y., Condon, K. W., Bivi, N., Allen, M. R., Dwyer, D., Stolina, M., Turner, C. H., Robling, A. G., Plotkin, L. I., et al. (2011) · Bone · doi:10.1016/j.bone.2011.10.025 · Cited by 458 · see citing works

Therapeutic modulation of Notch signalling — are we there yet?

Andersson, E. R., & Lendahl, U. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4252 · Cited by 452 · see citing works

Gap junctions and connexin-interacting proteins

Giepmans, B. N. G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.009 · Cited by 449 · see citing works

The mechanosensitive Piezo1 channel is required for bone formation

Sun, W., Chi, S., Li, Y., Ling, S., Tan, Y., Xu, Y., Jiang, F., Li, J., Liu, C., Zhong, G., et al. (2019) · eLife · doi:10.7554/elife.47454 · Cited by 439 · see citing works

Mechanical Signaling for Bone Modeling and Remodeling

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Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats

Mosley, J. R., & Lanyon, L. E. (1998) · Bone · doi:10.1016/s8756-3282(98)00113-6 · Cited by 417 · see citing works

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

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Mechanical regulation of signaling pathways in bone

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The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment

Sawakami, K., Robling, A. G., Ai, M., Pitner, N. D., Liu, D., Warden, S. J., Li, J., Maye, P. F., Rowe, D. W., Duncan, R. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601000200 · Cited by 397 · see citing works

Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction

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Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element

de Souza, R. L., Matsuura, M., Eckstein, F., Rawlinson, S. C. F., Lanyon, L. E., & Pitsillides, A. A. (2005) · Bone · doi:10.1016/j.bone.2005.07.022 · Cited by 378 · see citing works

Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice <i>in vivo</i>

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The role of collagen in determining bone mechanical properties

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WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

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Stimulation of Piezo1 by mechanical signals promotes bone anabolism

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An incredible decade for the primary cilium: a look at a once-forgotten organelle

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Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

Cardoso, L., Herman, B. C., Verborgt, O., Laudier, D., Majeska, R. J., & Schaffler, M. B. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081210 · Cited by 340 · see citing works

Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton

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The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low‐magnitude mechanical stimuli

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Mechanical Properties of the Cytoskeleton and CellsPreprint

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E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation

Zhang, K., Barragan‐Adjemian, C., Ye, L., Kotha, S. P., Dallas, M., Lu, Y., Zhao, S., Harris, M. A., Harris, S. E., Feng, J. Q., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02120-05 · Cited by 299 · see citing works

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro

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Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models

Su, N. Y., Jin, M. Y., & Chen, L. (2014) · Bone Research · doi:10.1038/boneres.2014.3 · Cited by 291 · see citing works

Pulsating Fluid Flow Stimulates Prostaglandin Release and Inducible Prostaglandin G/H Synthase mRNA Expression in Primary Mouse Bone Cells

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Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

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Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs

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Strain magnitude related changes in whole bone architecture in growing rats

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Articular cartilage and biomechanical properties of the long bones in Frzb‐knockout mice

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The role of leptin in regulating bone metabolism

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Osteocyte: the unrecognized side of bone tissue

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A model for the role of integrins in flow induced mechanotransduction in osteocytes

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Cellular senescence in bone

Farr, J. N., & Khosla, S. (2019) · Bone · doi:10.1016/j.bone.2019.01.015 · Cited by 263 · see citing works

Steps in Mechanotransduction Pathways that Control Cell Morphology

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Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261 · see citing works

Pulsating Fluid Flow Increases Prostaglandin Production by Cultured Chicken Osteocytes—A Cytoskeleton-Dependent Process

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Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

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MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

Tang, Y., Rowe, R. G., Botvinick, E. L., Kurup, A., Putnam, A. J., Seiki, M., Weaver, V. M., Keller, E. T., Goldstein, S. A., Dai, J., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.011 · Cited by 253 · see citing works

Ciliary disorder of the skeleton

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Integrin expression in human bone

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Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia

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Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

Moustafa, A., Sugiyama, T., Prasad, J., Zaman, G., Gross, T. S., Lanyon, L. E., & Price, J. S. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1656-4 · Cited by 241 · see citing works

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels

Batra, N. R., Burra, S., Siller-Jackson, A. J., Gu, S., Xia, X., Weber, G. F., DeSimone, D. W., Bonewald, L. F., Lafer, E. M., Sprague, E. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115967109 · Cited by 240 · see citing works

The organization of the osteocyte network mirrors the extracellular matrix orientation in bone

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Osteocyte Signaling in Bone

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Integrins and signaling in osteoclast function

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Gap junctional complexes: From partners to functions

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Aging, Osteocytes, and Mechanotransduction

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The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity

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Attachment of Osteocyte Cell Processes to the Bone Matrix

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Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte-Like MLO-Y4 Cells

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Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

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