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Cited by 434

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis

Open access
Gimbrone, Michael A., García-Cardeña, Guillermo·2013·Cardiovascular Pathology
DOI 10.1016/j.carpath.2012.06.006
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Abstract

The localization of atherosclerotic lesion formation to regions of disturbed blood flow associated with certain arterial geometries, in humans and experimental animals, suggests an important role for hemodynamic forces in the pathobiology of atherosclerosis. There is increasing evidence that the vascular endothelium, which is directly exposed to various fluid mechanical forces generated by pulsatile blood flow, can discriminate among these different biomechanical stimuli and transduce them into genetic regulatory programs that modulate endothelial function. In this brief review, we discuss how biomechanical stimuli generated by blood flow can influence endothelial functional phenotypes, and explore the working hypothesis of “atheroprone” hemodynamic environments as “local risk factors” in atherogenesis. In addition, we consider the therapeutic implications of the activation of “atheroprotective genes” and their role as “critical regulatory nodes” in vascular homeostasis.

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Crossref · 10.1016/j.carpath.2012.06.006

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Metadata

Authors
Gimbrone, M. A., & García-Cardeña, G.
Venue
Cardiovascular Pathology
Publisher
Elsevier BV
Published
2013-01
Volume
22
Issue
1
Pages
9-15
ISSN
1054-8807 (ISSN-L)
DOI
10.1016/j.carpath.2012.06.006
OpenAlex
W1994491528
Cited by
434
References
65
FWCI
9.12
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. https://app.cochat.ai/papers/10.1016/j.carpath.2012.06.006
The paper
Gimbrone, M. A., & García-Cardeña, G. (2013). Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovascular Pathology. https://doi.org/10.1016/j.carpath.2012.06.006

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.