Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity
Abstract
During the last decade brown seaweeds attracted much attention as a source of polysaccharides, namely laminarans, alginic acids, and sulfated polysaccharides-fucoidans, with various structures and biological activities. In this study, sulfated polysaccharides were isolated from brown seaweeds Saccharina japonica (formerly named Laminaria) and Undaria pinnatifida and their antitumor activity was tested against human breast cancer T-47D and melanoma SK-MEL-28 cell lines. The sulfated polysaccharide form S. japonica was highly branched partially acetylated sulfated galactofucan, built up of (1→3)-α-L-fucose residues. The sulfated polysaccharide from U. pinnatifida was partially acetylated highly sulfated galactofucan consisting of (1→3)- or (1→3);(1→4)-α-L-fucose residues. Fucoidans from S. japonica and U. pinnatifida distinctly inhibited proliferation and colony formation in both breast cancer and melanoma cell lines in a dose-dependent manner. These results indicated that the use of sulfated polysaccharides from brown seaweeds S. japonica and U. pinnatifida might be a potential approach for cancer treatment.
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Fucoidans induce apoptosis of HT-29, HCT116, HCT-15 colon cancer cells, MCF-7, SK-Mel-28, T-47D, and human promyeloid leukemic cell lines.
“Fucoidans were shown to induce apoptosis of some other cancer cells, for example HT-29, HCT116, and HCT-15 human colon cancer cells [42,43] as well as MCF-7 (breast adenocarcinoma) [44], melanoma SK-Mel-28, breast cancer T-47D [45], and human promyeloid leukemic cell lines [46].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [45]
Cancer preventive properties of fucoidans have been shown in many experiments.
“Cancer preventive properties of fucoidans have been shown in many experiments.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [45]
Decrease of clonogenic growth of tumor cells was demonstrated after treatment with fucoidans.
“For example, decrease of clonogenic growth of tumor cells was demonstrated after treatment with fucoidans [30,45,56].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [45]
Inhibition of cell transformation provided evidence of anti-tumorigenic potential of fucoidans from A. nodosum, S. japonica, U. pinnatifida, Alaria sp., and F. evanescens.
“The inhibition of cell transformation provided evidence on the anti-tumorigenic potential of fucoidans from A. nodosum [57], S. japonica, U. pinnatifida, Alaria sp., and F. evanescens [29,45,58].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [45]
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References 40 · Cited by 267
- Authors
- Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N.
- Affiliations
- Russian Academy of Sciences (RU)
- Venue
- Carbohydrate Research
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 346
- Issue
- 17
- Pages
- 2769-2776
- ISSN
- 0008-6215 (ISSN-L)
- OpenAlex
- W2018502785
- Cited by
- 267
- References
- 40
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 29 · 2020: 28 · 2019: 22 · 2018: 22 · 2017: 18 · 2016: 13 · 2015: 17 · 2014: 17 · 2013: 17 · 2012: 8
- FWCI
- 20.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- sulfated polysaccharides, brown algae, Laminaria japonica, Undaria pinnatifida, fucoidan, anticancer activity, breast cancer, melanoma, cell proliferation inhibition, polysaccharide structure, acetylation
- MeSH terms
- Antineoplastic Agents, Carbohydrate Conformation, Carbohydrate Sequence, Cell Survival, Chromatography, Ion Exchange, Fucose, Galactans, Glucose, Humans, Molecular Sequence Data, Seaweed, Spectrophotometry, Infrared, Sulfuric Acid Esters, Cell Line, Tumor, Cell Proliferation
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