The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.
The interaction of flavonoids with mitochondria: effects on energetic processes
Abstract
The study addressed aspects of energetics of isolated rat liver mitochondria exposed to the flavonoids quercetin, taxifolin, catechin and galangin, taking into account influences of the 2,3 double bond/3-OH group and 4-oxo function on the C-ring, and o-di-OH on the B-ring of their structures, as well as mitochondrial mechanisms potentially involved in cell necrosis and apoptosis. The major findings/hypothesis, were: The 2,3 double bond/3-OH group in conjugation with the 4-oxo function on the C-ring in the flavonoid structure seems favour the interaction of these compounds with the mitochondrial membrane, decreasing its fluidity either inhibiting the respiratory chain of mitochondria or causing uncoupling; while the o-di-OH on the B-ring seems favour the respiratory chain inhibition, the absence of this structure seems favour the uncoupling activity. The flavonoids not affecting the respiration of mitochondria, induced MPT. The ability of flavonoids to induce the release of mitochondria-accumulated Ca(2+) correlated well with their ability to affect mitochondrial respiration on the one hand, and their inability to induce MPT, on the other. The flavonoids causing substantial respiratory chain inhibition or mitochondrial uncoupling, quercetin and galangin, respectively, also decreased the mitochondrial ATP levels, thus suggesting an apparent higher potential for necrosis induction in relation to the flavonoids inducing MPT, taxifolin and cathechin, which did not decrease significantly the ATP levels, rather suggesting an apparent higher potential for apoptosis induction.
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“Furthermore, quercetin can stimulate mitochondria oxidative metabolism by directly decreasing ATP:AMP ratio, which in turn results in the activation of AMPK and its downstream catabolic pathways (Dorta et al., 2005).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Dorta et al., 2005
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Flavonoids as Anticancer Agents
Kopustinskienė, D. M., Jakštas, V., Savickas, A., & Bernatonienė, J. (2020) · Nutrients · doi:10.3390/nu12020457 · Cited by 1,420
The Role of Catechins in Cellular Responses to Oxidative Stress
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Metadata
- Authors
- Dorta, D. J., Pigoso, A. A., Mingatto, F. E., Rodrigues, T., Prado, I. M. R., Helena, A. F. C., Uyemura, S. A., Santos, A. C., & Curti, C.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Curti, Carlos
- ORCID
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 152
- Issue
- 2-3
- Pages
- 67-78
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2042065066
- Cited by
- 165
- References
- 46
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 13 · 2018: 11 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 4 · 2012: 8
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de São Paulo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- flavonoids, mitochondria, quercetin, taxifolin, catechins, galangin, mitochondrial permeability transition, mitochondrial uncoupling, electron transport inhibition, mitochondrial membrane fluidity, mitochondrial calcium release, mitochondrial ATP, apoptosis, necrosis, structure-activity relationship, liver mitochondria
- MeSH terms
- Adenosine Triphosphate, Animals, Calcium, Catechin, Flavonoids, Intracellular Membranes, Luminescent Measurements, Male, Membrane Fluidity, Mitochondria, Liver, Polarography, Quercetin, Structure-Activity Relationship, Rats, Wistar, Cell Respiration, Flavonols, Rats
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