Cited by 165Mitochondrial Function and PathologyFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

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The interaction of flavonoids with mitochondria: effects on energetic processes

Dorta, Daniel J., Pigoso, Acácio A., Mingatto, Fábio E., Rodrigues, Tiago, Prado, Ieda M.R., Helena, Anaísa F.C., Uyemura, Sérgio A., Santos, Antonio C., Curti, Carlos·2005·Chemico-Biological Interactions

DOI 10.1016/j.cbi.2005.02.004

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Abstract

The study addressed aspects of energetics of isolated rat liver mitochondria exposed to the flavonoids quercetin, taxifolin, catechin and galangin, taking into account influences of the 2,3 double bond/3-OH group and 4-oxo function on the C-ring, and o-di-OH on the B-ring of their structures, as well as mitochondrial mechanisms potentially involved in cell necrosis and apoptosis. The major findings/hypothesis, were: The 2,3 double bond/3-OH group in conjugation with the 4-oxo function on the C-ring in the flavonoid structure seems favour the interaction of these compounds with the mitochondrial membrane, decreasing its fluidity either inhibiting the respiratory chain of mitochondria or causing uncoupling; while the o-di-OH on the B-ring seems favour the respiratory chain inhibition, the absence of this structure seems favour the uncoupling activity. The flavonoids not affecting the respiration of mitochondria, induced MPT. The ability of flavonoids to induce the release of mitochondria-accumulated Ca(2+) correlated well with their ability to affect mitochondrial respiration on the one hand, and their inability to induce MPT, on the other. The flavonoids causing substantial respiratory chain inhibition or mitochondrial uncoupling, quercetin and galangin, respectively, also decreased the mitochondrial ATP levels, thus suggesting an apparent higher potential for necrosis induction in relation to the flavonoids inducing MPT, taxifolin and cathechin, which did not decrease significantly the ATP levels, rather suggesting an apparent higher potential for apoptosis induction.

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Salvi, 2002, Interaction of genistein with the mitochondrial electron transport chain results in opening of the membrane transition pore, Biochim. Biophys. Acta, 1556, 187, 10.1016/S0005-2728(02)00361-4 · DOI

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Authors: Dorta, D. J., Pigoso, A. A., Mingatto, F. E., Rodrigues, T., Prado, I. M. R., Helena, A. F. C., Uyemura, S. A., Santos, A. C., & Curti, C.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Curti, Carlos
ORCID: Dorta, Daniel J.
Pigoso, Acácio A.
Mingatto, Fábio E.
Rodrigues, Tiago
Uyemura, Sérgio A.
Santos, Antonio C.
Curti, Carlos
Venue: Chemico-Biological Interactions
Publisher: Elsevier BV
Published: 2005-04
Volume: 152
Issue: 2-3
Pages: 67-78
ISSN: 0009-2797 (ISSN-L)
DOI: 10.1016/j.cbi.2005.02.004
OpenAlex: W2042065066
Cited by: 165
References: 46
Citations by year: 2026: 6 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 13 · 2018: 11 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 4 · 2012: 8
FWCI: 2.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Chemico-Biological Interactions (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Universidade de São Paulo
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: flavonoids, mitochondria, quercetin, taxifolin, catechins, galangin, mitochondrial permeability transition, mitochondrial uncoupling, electron transport inhibition, mitochondrial membrane fluidity, mitochondrial calcium release, mitochondrial ATP, apoptosis, necrosis, structure-activity relationship, liver mitochondria
MeSH terms: Adenosine Triphosphate, Animals, Calcium, Catechin, Flavonoids, Intracellular Membranes, Luminescent Measurements, Male, Membrane Fluidity, Mitochondria, Liver, Polarography, Quercetin, Structure-Activity Relationship, Rats, Wistar, Cell Respiration, Flavonols, Rats

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The interaction of flavonoids with mitochondria: effects on energetic processes

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