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Glycomics and disease markers
Open accessAbstract
Summary of Recent Advances Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferase. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased due to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.
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Citations
Cited by
Insights into the role of sialylation in cancer progression and metastasis
Dobie, C., & Skropeta, D. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01126-7 · Cited by 348
High-Mannose Glycans are Elevated during Breast Cancer Progression
de Leoz, M. L. A., Young, L. J. T., An, H. J., Kronewitter, S. R., Kim, J., Miyamoto, S., Borowsky, A. D., Chew, H. K., & Lebrilla, C. B. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002717 · Cited by 320
Self-citationZhang, J., Guy, M. J., Norman, H. S., Chen, Y.-C., Xu, Q., Dong, X., Guner, H., Wang, S., Kohmoto, T., Young, K. H., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200258m · Cited by 194
Varki, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005462 · Cited by 173
New Technologies for Glycomic Analysis: Toward a Systematic Understanding of the Glycome
Rakus, J. F., & Mahal, L. K. (2011) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061010-113951 · Cited by 117
Metadata
- Authors
- An, H. J., Kronewitter, S. R., de Leoz, M. L. A., & Lebrilla, C. B.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 13
- Issue
- 5-6
- Pages
- 601-607
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W2084766638
- Cited by
- 267
- References
- 0
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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- An, H. J., Kronewitter, S. R., de Leoz, M. L. A., & Lebrilla, C. B. (2009). Glycomics and disease markers. Current Opinion in Chemical Biology. https://doi.org/10.1016/j.cbpa.2009.08.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
