The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Protein conjugation with genetically encoded unnatural amino acids
Open accessAbstract
The site-specific incorporation of unnatural amino acids with orthogonal chemical reactivity into proteins enables the synthesis of structurally-defined protein conjugates. Amino acids containing ketone, azide, alkyne, alkene, and tetrazine side chains can be genetically encoded in response to nonsense and frameshift codons. These bio-orthogonal chemical handles allow precise control over the site and stoichiometry of conjugation, and have enabled medicinal chemistry-like optimization of the physical and biological properties of protein conjugates, especially the next-generation protein therapeutics.
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Citations
Cites
Adding New Chemistries to the Genetic Code
Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725
Self-citationEncoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome
Neumann, H., Wang, K., Davis, L., Garcia-Alai, M., & Chin, J. W. (2010) · Nature · doi:10.1038/nature08817 · Cited by 622
Natural expansion of the genetic code
Ambrogelly, A., Palioura, S., & Söll, D. (2007) · Nature Chemical Biology · doi:10.1038/nchembio847 · Cited by 361
Bispecific antibodies for cancer therapy: The light at the end of the tunnel?
Chames, P., & Baty, D. (2009) · mAbs · doi:10.4161/mabs.1.6.10015 · Cited by 336
Cited by
Expanding and Reprogramming the Genetic Code of Cells and Animals
Chin, J. W. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035737 · Cited by 476
Schmied, W. H., Elsässer, S. J., Uttamapinant, C., & Chin, J. W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5069728 · Cited by 270
Metadata
- Authors
- Kim, C. H., Axup, J. Y., & Schultz, P. G.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 17
- Issue
- 3
- Pages
- 412-419
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W2094654556
- Cited by
- 269
- References
- 4
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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