Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region
Open accessAbstract
Fluorescence imaging is an indispensable method for studying biological processes non-invasively in cells and transparent organisms. Extension into the shortwave infrared (SWIR, 1000-2000 nm) region of the electromagnetic spectrum has allowed for imaging in mammals with unprecedented depth and resolution for optical imaging. In this review, we summarize recent advances in imaging technologies, dye scaffold modifications, and incorporation of these dyes into probes for SWIR imaging in mice. Finally, we offer an outlook on the future of SWIR detection in the field of chemical biology.
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Increasing the number of conjugated double bonds tends to lead to fragile chemical structures and poor photostability, as exemplified by cyanine dyes.
“In general, increasing the number of conjugated double bonds tends to lead to fragile chemical structures and poor photostability, as exemplified by cyanine dyes217.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [217]
The “Polymethine dyes” subsection says these dyes often have lower photostability than donor–acceptor–donor dyes and separately describes extending their polymethine chains. It does not say that adding conjugated double bonds causes poor photostability or fragile chemical structures. (LLM, conf=0.86)
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References 76 · Cited by 31
- Authors
- Wong, K. C. Y., & Sletten, E. M.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Sletten, Ellen M.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 68
- Pages
- 102131
- ISSN
- 1367-5931 (ISSN-L)
- PMC
- PMC9583727
- OpenAlex
- W4220693708
- Cited by
- 31
- References
- 76
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 302 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Opinion in Chemical Biology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of General Medical Sciences
- National Institute of Biomedical Imaging and Bioengineering
- National Science Foundation (DGE -2034835, CHE -1905242)
- National Institute of Health
- Alfred P Sloan Foundation (FG -2018-10855)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- short-wave infrared imaging, fluorescence imaging, chemical probes, deep tissue imaging, mouse model, optical imaging, chemical biology tools
- MeSH terms
- Animals, Fluorescent Dyes, Mammals, Mice, Optical Imaging
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