Investigation of MDA-LDL (malondialdehyde-modified low-density lipoprotein) as a prognostic marker for coronary artery disease in patients with type 2 diabetes mellitus
Open accessAbstract
Background Although increased circulating levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL) are associated with coronary artery disease (CAD), there is no direct evidence that increased MDA-LDL is a prognostic factor for CAD.Methods Forty-two patients (20 diabetic and 22 non-diabetic patients) who underwent percutaneous coronary intervention (PCI) were enrolled, and their baseline MDA-LDL levels were determined by immunoassay. Follow-up coronary angiography was performed at 2 to 7 months post-PCI. The patients were then divided into 2 groups, with in-stent restenosis (ISR) (n=13) and without ISR (n=29), and the baseline MDA-LDL levels were compared. We also studied 34 diabetics with CAD for up to 57 months until the onset of the next coronary event.Results In the diabetic patients, the mean MDA-LDL level was significantly higher in those with ISR than in those without ISR (151+/-61 vs. 90+/-26 U/l, p=0.010). A baseline MDA-LDL value of 110 U/l for differentiating between diabetics with and without ISR was defined as the cut-off value. Kaplan-Meier analysis demonstrated that a circulating MDA-LDL of ≥ 110 U/l correlated significantly with a higher prevalence of cardiac events than MDA-LDL <110 U/l (p=0.032).Conclusions Circulating MDA-LDL is a useful prognostic marker for future cardiac event in diabetic patients with CAD.
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MDA-LDL is involved in a wide range of processes of atherosclerosis, such as the damaging of endothelial cells, acceleration of monocyte penetration into the vascular walls, and formation of foam cells.
“MDA-LDL is involved in a wide range of processes of atherosclerosis, such as the damaging of endothelial cells, acceleration of monocyte penetration into the vascular walls, and formation of foam cells235).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [235]
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- Authors
- Kotani, K., Tashiro, J., Yamazaki, K., Nakamura, Y., Miyazaki, A., Bujo, H., Saito, Y., Kanno, T., & Maekawa, M.
- Affiliations
- Hamamatsu University (JP)
- Matsudo City Hospital (JP)
- Chiba Cerebral and Cardiovascular Center (JP)
- Toho University (JP)
- Hamamatsu University School of Medicine (JP)
- Corresponding author
- Kotani, Kazuo
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 450
- Pages
- 145-150
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2205570946
- Cited by
- 24
- References
- 25
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-04-01)
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- HamaMed-Repository (Hamamatsu University School of Medicine) (submittedVersion, cc-by-nc-nd)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (15H04760, 26670275)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- malondialdehyde-modified low-density lipoprotein, coronary artery disease, type 2 diabetes, in-stent restenosis, prognostic factors, percutaneous coronary intervention, lipid peroxidation, cardiovascular events, cut-off values
- MeSH terms
- Aged, Coronary Artery Disease, Diabetes Mellitus, Type 2, Female, Humans, Lipoproteins, LDL, Male, Malondialdehyde, Prognosis, Biomarkers, Percutaneous Coronary Intervention
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