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Long non-coding RNA in lung cancer
Abstract
Lung cancer is the leading cause of cancer-related death worldwide. Owing to the difficulty in early diagnosis and the lack of effective treatment strategies, the 5-year survival rates for lung cancer remain very low. With the development of whole genome and transcriptome sequencing technology, long non-coding RNA (lncRNA) has attracted increasing attention. LncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels and are widely involved in a variety of diseases, including tumorigenesis. In lung cancer studies, multiple differentially expressed lncRNAs have been identified; several lncRNAs were identified as oncogenic lncRNAs with tumor-driving effects, while other lncRNAs play a role in tumor inhibition and are called tumor-suppressive lncRNAs. These tumor-suppressive lncRNAs are involved in multiple physiological processes such as cell proliferation, apoptosis, and metastasis and thus participate in tumor progression. In this review, we discussed the oncogenic and tumor-suppressive lncRNAs in lung cancer, as well as their biological functions and regulatory mechanisms. Furthermore, we found the potential significance of lncRNAs in clinical diagnosis and treatment.
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“they can influence the expression of other genes through multiple mechanisms to cause a wide range of disorders.215–218”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [216]
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Metadata
- Authors
- Chen, Z., Lei, T., Chen, X., Gu, J., Huang, J., Lu, B., & Wang, Z.
- Affiliations
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Corresponding author
- Lu, Binbin
- Wang, Zhaoxia
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 504
- Pages
- 190-200
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2990143159
- Cited by
- 65
- References
- 171
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 9 · 2020: 8
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jiangsu Science and Technology Department (BE2019760)
- National Natural Science Foundation of China (81672307, 81871871, 81902333)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- long non-coding RNA, lung cancer, oncogenic lncRNA, lncRNA regulation of gene expression, epigenetic regulation, tumor progression, metastasis, cell proliferation, apoptosis
- MeSH terms
- Humans, Lung Neoplasms, Gene Expression Regulation, Neoplastic, RNA, Long Noncoding
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